| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2019: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2018: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
It is commonly accepted that ECM (extracellular matrix) orientation follows the cellular alignment; however, we demonstrated the abnormal arrangement of bone matrix orthogonal to osteoblast arrangement using a nanoscale grooved biomaterial surface. Notably, the discovery was associated with fibrillar adhesion formation along the nanogrooves. The comprehensive gene expression analysis revealed that the integrin clustering mediated by Tspan11 determines the alignment of bone matrix architecture orthogonal to cell alignment. Our findings offer new strategies to realize the ideal microstructure of bone tissue as well as provide molecular mechanisms for texture formation in biological systems.
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