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Molecular understanding of abnormal arrangement of a collagen/apatite extracellular matrix orthogonal to osteoblast alignment

Research Project

Project/Area Number 17H04955
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Structural/Functional materials
Research InstitutionOsaka University

Principal Investigator

Matsugaki Aira  大阪大学, 工学研究科, 特任講師(常勤) (10592529)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2019: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2018: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords細胞配列 / 骨配向性 / 骨芽細胞 / 直交配向化 / 接着斑 / アパタイト / 直交配向 / 遺伝子 / 細胞配向
Outline of Final Research Achievements

It is commonly accepted that ECM (extracellular matrix) orientation follows the cellular alignment; however, we demonstrated the abnormal arrangement of bone matrix orthogonal to osteoblast arrangement using a nanoscale grooved biomaterial surface. Notably, the discovery was associated with fibrillar adhesion formation along the nanogrooves. The comprehensive gene expression analysis revealed that the integrin clustering mediated by Tspan11 determines the alignment of bone matrix architecture orthogonal to cell alignment. Our findings offer new strategies to realize the ideal microstructure of bone tissue as well as provide molecular mechanisms for texture formation in biological systems.

Academic Significance and Societal Importance of the Research Achievements

既存の骨研究は骨量・骨密度回復を目的とし、骨配向性の概念すら存在しなかった。ましてや骨配向性制御の生体分子メカニズム、すなわち結晶レベルでの異方性を細胞がいかにして生み出すのか?という、骨研究のまさに真髄であり生体材料学の最重要研究課題に到達していないのが現状である。本研究では、研究代表者らが世界に先駆けて発見した「直交性」および「平行性」骨配向化について遺伝子レベルからその機序解明を達成しており、本成果に基づいて部位や種類に応じて様々な配向方向・配向度を示す骨の配向性を自由自在にコントロール可能となる、極めて独創性が高く、基礎・実用研究両面において意義深い研究課題である。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (64 results)

All 2020 2019 2018 2017 Other

All Journal Article (24 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 24 results,  Open Access: 16 results,  Acknowledgement Compliant: 4 results) Presentation (37 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Selective patterning of netrin-1 as a novel guiding cue for anisotropic dendrogenesis in osteocytes2020

    • Author(s)
      Aira Matsugaki, Daisuke Yamazaki, Takayoshi Nakano
    • Journal Title

      Materials Science & Engineering C

      Volume: 108 Pages: 110391-110391

    • DOI

      10.1016/j.msec.2019.110391

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Control of crystallographic orientation by metal additive manufacturing process of β-type Ti alloys based on the bone tissue anisotropy2020

    • Author(s)
      Takayoshi Nakano, Takuya Ishimoto, Aira Matsugaki, Koji Hagihara, Yuichiro Koizumi and Ryosuke Ozasa
    • Journal Title

      Proceedings of The 14th World Conference on Titanium

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique arrangement of bone matrix orthogonal to osteoblast alignment controlled by Tspan11-mediated focal adhesion assembly2019

    • Author(s)
      Yohei Nakanishi, Aira Matsugaki, Kosuke Kawahara, Takafumi Ninomiya, Hiroshi Sawada, Takayoshi Nakano
    • Journal Title

      Biomaterials

      Volume: 209 Pages: 103-110

    • DOI

      10.1016/j.biomaterials.2019.04.016

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生体骨における自己組織化現象と代替材料への応用2019

    • Author(s)
      松垣あいら, 中野貴由
    • Journal Title

      化学工業

      Volume: 70 Pages: 44-49

    • NAID

      40022080030

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 表面形状による細胞・骨配向化制御~ナノ配向溝による特異な直交性骨配向化現象~2019

    • Author(s)
      松垣あいら, 中野貴由
    • Journal Title

      バイオマテリアル-生体材料-

      Volume: 37 Pages: 270-271

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 応力による骨のリモデリング―骨配向性と骨再生を促す表面形態2019

    • Author(s)
      松垣あいら, 中野貴由
    • Journal Title

      現代化学

      Volume: 580 Pages: 56-59

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-resistant properties of cross-linking PTFE for medical use2019

    • Author(s)
      Hiroshi Saito, Masakazu Furuta, Aira Matsugaki, Takayoshi Nakano, Masako Oishi, Masayuki Okazaki
    • Journal Title

      Polymer Bulletin

      Volume: in press Issue: 12 Pages: 6111-6122

    • DOI

      10.1007/s00289-019-02698-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of bifunctional oriented bioactive glass / poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation2019

    • Author(s)
      Sungho Lee, Aira Matsugaki, Toshihiro Kasuga, Takayoshi Nakano
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 107 Issue: 5 Pages: 1031-1041

    • DOI

      10.1002/jbm.a.36619

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 応力による骨のリモデリングー骨配向性と骨再生を促す表面形態2019

    • Author(s)
      松垣あいら、中野貴由
    • Journal Title

      現代化学

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Collision Behavior Between Osteoblasts and Tumor Cells Regulates the Disordered Arrangement of Collagen Fiber/Apatite Crystals in Metastasized Bone2018

    • Author(s)
      A. Matsugaki, T. Harada, Y. Kimura, A. Sekita, T. Nakano
    • Journal Title

      Int. J. Mol. Sci

      Volume: 19 Issue: 11 Pages: 3474-3474

    • DOI

      10.3390/ijms19113474

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Construction of human induced pluripotent stem cell-derived oriented bone matrix microstructure by using in vitro engineered anisotropic culture model2018

    • Author(s)
      Ryosuke Ozasa, Aira Matsugaki, Yoshihiro Isobe, Taro Saku, Yun Hui-suk, Takayoshi Nakano
    • Journal Title

      Journal of Biomedical Materials Research: Part A

      Volume: 106 Issue: 2 Pages: 360-369

    • DOI

      10.1002/jbm.a.36238

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 骨配向化誘導のためのチタン表面形状制御による新規生体材料創製2018

    • Author(s)
      松垣あいら
    • Journal Title

      チタン

      Volume: 66 Pages: 24-24

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategy for Construction of Anisotropic Bone Matrix by Using Biomedical Materials2018

    • Author(s)
      松垣あいら、中野貴由
    • Journal Title

      KOBUNSHI RONBUNSHU

      Volume: 75 Issue: 2 Pages: 164-173

    • DOI

      10.1295/koron.2017-0077

    • NAID

      130006528522

    • ISSN
      0386-2186, 1881-5685
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preferential Arrangement of Mature Osteoblast from Juvenile Mouse Calvariae on the Oriented Collagen Substrate2017

    • Author(s)
      小笹良輔、松垣あいら、礒部仁博、佐久太郎、中野貴由
    • Journal Title

      Journal of the Japan Institute of Metals and Materials

      Volume: 81 Issue: 10 Pages: 480-484

    • DOI

      10.2320/jinstmet.J2017027

    • NAID

      130006096656

    • ISSN
      0021-4876, 1880-6880, 2433-7501
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of osteoblast arrangement via direct attack by cancer cells: New insights into bone metastasis2017

    • Author(s)
      Y. Kimura, A. Matsugaki, A. Sekita, T. Nakano
    • Journal Title

      Scientific Reports

      Volume: 44824 Issue: 1 Pages: 1-11

    • DOI

      10.1038/srep44824

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association between Intraosseous Vasculature and Bone Matrix Anisotropy Analyzed with a Novel Visualization Method2017

    • Author(s)
      関田愛子、松垣あいら、小笹良輔、中野貴由
    • Journal Title

      Journal of the Japan Institute of Metals and Materials

      Volume: 81 Issue: 6 Pages: 315-319

    • DOI

      10.2320/jinstmet.J2017005

    • NAID

      130005678931

    • ISSN
      0021-4876, 1880-6880, 2433-7501
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Disruption of collagen/apatite alignment impairs bone mechanical function in osteoblastic metastasis induced by prostate cancer2017

    • Author(s)
      A. Sekita, A. Matsugaki, T. Nakano
    • Journal Title

      Bone

      Volume: 97 Pages: 83-93

    • DOI

      10.1016/j.bone.2017.01.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular level analysis of mechinical properties of PTFE sterilized by Co-60 γ-ray irradiation for clincal use2017

    • Author(s)
      M. Okazaki, M. Furuta, A. Matsugaki, T. Nakano, I. Hirata, K. Kato, T. Oda, M. Sato
    • Journal Title

      Radiation Physics and Chemistry

      Volume: in press Pages: 126-131

    • DOI

      10.1016/j.radphyschem.2017.04.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Directional Control of Mature Osteoblast Derived from Juvenile Mouse Calvariae2017

    • Author(s)
      R. Ozasa, A. Matsugaki and T. Nakano
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 58 Issue: 6 Pages: 958-962

    • DOI

      10.2320/matertrans.M2017077

    • NAID

      130005679019

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired Bone Matrix Alignment Induced by Breast Cancer Metastasis2017

    • Author(s)
      関田愛子、松垣あいら、中野貴由
    • Journal Title

      Journal of the Japan Institute of Metals and Materials

      Volume: 81 Issue: 6 Pages: 308-314

    • DOI

      10.2320/jinstmet.J2017003

    • NAID

      130005678932

    • ISSN
      0021-4876, 1880-6880, 2433-7501
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural Crosstalk between Crystallographic Anisotropy in Bone Tissue and Vascular Network Analyzed with a Novel Visualization Method2017

    • Author(s)
      Aiko Sekita, Aira Matsugaki and Takayoshi Nakano
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 58 Issue: 2 Pages: 266-270

    • DOI

      10.2320/matertrans.M2016383

    • NAID

      130005297209

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel TiNbTaZrMo high-entropy alloys for metallic biomaterials2017

    • Author(s)
      Mitsuharu Todai, Takeshi Nagase, Takao Hori, Aira Matsugaki, Aiko Sekita, Takayoshi Nakano
    • Journal Title

      Scripta Materialia

      Volume: 129 Pages: 65-68

    • DOI

      10.1016/j.scriptamat.2016.10.028

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Design of the Next Generation Metallic Biomaterials2017

    • Author(s)
      當代 光陽、石本 卓也、松垣 あいら、中野 貴由
    • Journal Title

      Materia Japan

      Volume: 56 Issue: 10 Pages: 584-588

    • DOI

      10.2320/materia.56.584

    • NAID

      130006109917

    • ISSN
      1340-2625, 1884-5843
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] がん細胞との直接接触が骨芽細胞配列化を阻害し、骨配向性低下をもたらす2017

    • Author(s)
      松垣あいら
    • Journal Title

      First author, 日本骨代謝学会

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 材料表面微細周期構造形成による骨芽細胞および骨基質配向化2020

    • Author(s)
      竹花諒、松垣あいら、川原公介、二宮孝文、沢田博司、中野貴由
    • Organizer
      日本金属学会2020年春期講演大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 材料表面形状による間葉系幹細胞制御2020

    • Author(s)
      若林誠、松垣あいら、孫世海、木村恒太、中野貴由
    • Organizer
      日本金属学会2020年春期講演大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Control of crystallographic orientation by metal additive manufacturing process of beta-type Ti alloys based on the bone tissue anisotropy2020

    • Author(s)
      T. Nakano, T. Ishimoto, A. Matsugaki, K. Hagihara, Y. Koizumi and R. Ozasa
    • Organizer
      The 14th Conference on Titanium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] バイオマテリアルによる細胞・骨配向化制御2019

    • Author(s)
      松垣あいら、中野貴由
    • Organizer
      第37回骨代謝学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 微細周期構造に依存した骨芽細胞および骨基質配向化挙動2019

    • Author(s)
      竹花諒、松垣あいら、川原公介、二宮孝文、沢田博司、中野貴由
    • Organizer
      日本金属学会2019年秋期講演大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 材料表面形状制御に基づく直交性骨配向化機構2019

    • Author(s)
      松垣あいら、中西陽平、中野貴由
    • Organizer
      日本金属学会2019年春期(第164回)講演大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ナノ表面構造による特異な「直交性骨基質配向化」機構2018

    • Author(s)
      松垣あいら、中西陽平、川原公介、二宮孝文、沢田博司、中野貴由
    • Organizer
      第40回日本バイオマテリアル学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ナノ表面形状制御による骨芽細胞および骨基質配向化機構2018

    • Author(s)
      中西 陽平、松垣 あいら、中野 貴由
    • Organizer
      日本金属学会2018年秋期講演大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] バイオマテリアル科学に基づく細胞・骨基質配向化イメージング2018

    • Author(s)
      松垣 あいら、中野 貴由
    • Organizer
      日本金属学会2018年秋期講演大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ヒトiPS 細胞由来骨芽細胞による配向化骨基質の形成2018

    • Author(s)
      小笹良輔、松垣あいら、中野貴由
    • Organizer
      第36回日本骨代謝学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ナノ周期表面構造による骨芽細胞および骨基質配向化機構2018

    • Author(s)
      中西 陽平、松垣 あいら、中野 貴由
    • Organizer
      第38回骨形態計測学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Formation of bone matrix perpendicular to osteoblast alignment in response to nanogrooves2018

    • Author(s)
      Y. Nakanishi, A. Matsugaki, T. Nakano
    • Organizer
      Biomaterials International 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オステオサイトを起点とする細胞間相互作用に基づく骨基質配向化機構2018

    • Author(s)
      松垣あいら、山崎大介、中野貴由
    • Organizer
      日本金属学会2018年春期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TiNbTaZrMo生体用ハイエントロピー合金の開発2017

    • Author(s)
      永瀬丈嗣、當代光陽、堀敬雄、松垣あいら、関田愛子、中野貴由
    • Organizer
      日本鋳造工学会第169回全国講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis and control of preferential alignment of apatite crystals related to collagen fibers in various bones and in vitro bone-like tissues2017

    • Author(s)
      T. Nakano, T. Ishimoto, A. Matsugaki
    • Organizer
      PACRIM12
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] iPS細胞由来骨芽細胞を用いた配向化骨基質形成2017

    • Author(s)
      小笹良輔、松垣あいら、中野貴由
    • Organizer
      第37回日本骨形態計測学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] オステオサイトを起点とする細胞間相互作用に基づく骨芽細胞配列化挙動2017

    • Author(s)
      松垣あいら、青木 洋、中野 貴由
    • Organizer
      第37回日本骨形態計測学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メラノーマ転移骨におけるオステオサイトネットワークおよびコラーゲン/アパタイト配向化構造の破綻2017

    • Author(s)
      関田 愛子、松垣あいら、中野 貴由
    • Organizer
      第37回日本骨形態計測学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん骨転移による骨配向性低下機構2017

    • Author(s)
      松垣あいら、中野 貴由
    • Organizer
      第35回日本骨代謝学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 背面照射型Ti/TiO2/Hanks液/SiO2光応答細胞培養器の試作2017

    • Author(s)
      藤田智香、上田正人、池田勝彦、松垣あいら、中野貴由
    • Organizer
      日本金属学会2017年秋期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ナノ表面形状制御による特異な骨基質配向化2017

    • Author(s)
      中西陽平、松垣あいら、中野貴由
    • Organizer
      日本金属学会2017年秋期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット大腿骨骨延長における骨配向化挙動解析2017

    • Author(s)
      杉本昌太、石本卓也、松垣あいら、中野貴由、吉田清志、大槻大、吉川秀樹
    • Organizer
      日本金属学会2017年秋期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] オステオサイトを起点とした骨配向化メカニズム解明2017

    • Author(s)
      山崎大介、松垣あいら、中野貴由
    • Organizer
      日本金属学会2017年秋期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] bcc型生体用ハイエントロピー合金の力学特性最適化に向けた組成選択2017

    • Author(s)
      堀敬雄、當代光陽、永瀬丈嗣、松垣あいら、藤谷渉、中野貴由
    • Organizer
      日本金属学会2017年秋期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 破骨細胞由来因子による骨配向性制御機構の解明2017

    • Author(s)
      小笹良輔、坂本康太、松垣あいら、中野貴由
    • Organizer
      日本金属学会2017年秋期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] パラメータ法を用いた新しいbcc型生体用ハイエントロピー合金の設計2017

    • Author(s)
      當代光陽、堀敬雄、永瀬丈嗣、松垣あいら、中野貴由
    • Organizer
      日本金属学会2017年秋期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 表面構造制御に基づく細胞・細胞外基質の異方性発現2017

    • Author(s)
      松垣あいら、中野貴由
    • Organizer
      日本金属学会2017年秋期講演大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 材料学を基軸にした細胞・組織異方性発現および配向化機構解明2017

    • Author(s)
      松垣あいら
    • Organizer
      日本金属学会2017年秋期講演大会(受賞講演)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨細胞と骨基質アパタイト配向性2017

    • Author(s)
      中野貴由、石本卓也、松垣あいら
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] チタン表面形状制御に基づく細胞・骨気質配向化誘導2017

    • Author(s)
      松垣あいら、中野貴由
    • Organizer
      日本チタン協会主催 第5回チタン若手交流会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Construction of anisotropic bone matrix microstructure by controlling human induced pluripotent stem cells2017

    • Author(s)
      Ryosuke Ozasa, Aira Matsugaki, Takayoshi Nakano
    • Organizer
      The 6th Asian Biomaterials Congress(ABMC6)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Unique alignment of bone extracellular matrix orthogonal to osteoblast arrangement controlled by nanoscale periodic surface topography,2017

    • Author(s)
      Yohei Nakanishi, Aira Matsugaki, Takayoshi Nakano
    • Organizer
      The 6th Asian Biomaterials Congress(ABMC6)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ナノ周期構造による直交性骨基質配向化機構2017

    • Author(s)
      中西陽平、松垣あいら、川原公介、二宮孝文、沢田博司、中野貴由
    • Organizer
      第38回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 破骨細胞を起点とした骨基質配向性制御機構2017

    • Author(s)
      小笹良輔、松垣あいら、中野貴由
    • Organizer
      第38回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生体骨模擬共培養システムによる骨配向化メカニズムの解明2017

    • Author(s)
      山崎大介、松垣あいら、中野貴由
    • Organizer
      第38回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん骨転移による異方性骨微細構造破綻機構2017

    • Author(s)
      松垣あいら、木村友美、関田愛子、中野貴由
    • Organizer
      第38回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 材料表面改変による細胞制御に基づく骨基質配向化誘導2017

    • Author(s)
      松垣あいら、中野貴由
    • Organizer
      日本材料学会第48回生体・医療材料部門委員会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 中野研究室HP

    • URL

      http://www.mat.eng.osaka-u.ac.jp/msp6/nakano/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Patent(Industrial Property Rights)] インプラント2019

    • Inventor(s)
      中野貴由、松垣あいら、沢田博司、川原公介
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-236174
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 薬剤組成物、及び疾患治療薬2017

    • Inventor(s)
      中野貴由、松垣あいら、石本卓也、小笹良輔
    • Industrial Property Rights Holder
      中野貴由、松垣あいら、石本卓也、小笹良輔
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-160852
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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