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Defect-free and large-scale formation of biomimetic reverse osmosis membranes using a liquid-liquid interface

Research Project

Project/Area Number 17H04963
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Properties in chemical engineering process/Transfer operation/Unit operation
Research InstitutionShinshu University (2018-2019)
Kobe University (2017)

Principal Investigator

SAEKI Daisuke  信州大学, 学術研究院工学系, 助教 (70633832)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords膜分離 / 逆浸透膜 / 生体模倣 / リポソーム / 脂質二分子膜 / 水チャネル
Outline of Final Research Achievements

The fabrication method of defect-free biomimetic reverse osmosis (RO) membranes with high water permeability and stability have been established. Simple structural biological molecules, gramicidin A or amphotericin B, were used as water channel. A supported lipid bilayer (SLB) containing these water channel molecules were formed onto a porous substrate with well-controlled surface structure and evaluated as RO membranes. The formed SLB had high stability against applied pressure and showed higher water permeability than the previously reported biomimetic RO membranes and commercial membranes.

Academic Significance and Societal Importance of the Research Achievements

従来の高分子系逆浸透膜は、既に性能向上が難しい現状にある。一方で、生体模倣型逆浸透膜は、理論的には高い性能が実現できると期待されている。しかしながら、水チャネルの機能発現や安定な脂質二分子膜形成が難しいなどの問題から、これまで、市販の高分子系逆浸透膜の性能を超える報告例はほとんどなかった。本研究では、水チャネルの選定と支持体の最適化、製膜方法の改良により、市販膜を超える透水性および実用的強度を兼ね備えた逆浸透膜の作製に成功し、実用化の可能性を示すことができた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (32 results)

All 2020 2019 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (24 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Effect of polyelectrolyte structure on formation of supported lipid bilayers on polyelectrolyte multilayers prepared using the layer-by-layer method2020

    • Author(s)
      A. Seimei, D. Saeki, H. Matsuyama
    • Journal Title

      Journal of Colloid and Interface Science

      Volume: 569 Pages: 211-218

    • DOI

      10.1016/j.jcis.2020.02.079

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase separation behavior of binary mixture of photopolymerizable diacetylene and unsaturated phospholipids in liposomes2020

    • Author(s)
      K. Okuno, D. Saeki, H. Matsuyama
    • Journal Title

      Biochimica et Biophysica Acta - Biomembranes

      Volume: 1862 Issue: 9 Pages: 183377-183377

    • DOI

      10.1016/j.bbamem.2020.183377

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular simulation of a modified amphotericin B-Ergosterol artificial water channel to evaluate structure and water molecule transport performance2019

    • Author(s)
      H. C. Wu, T. Yoshioka, K. Nakagawa, T. Shintani, D. Saeki, H. Matsuyama
    • Journal Title

      Journal of Membrane Science

      Volume: 583 Pages: 49-58

    • DOI

      10.1016/j.memsci.2019.04.021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Biomimetic Reverse Osmosis Membranes using Biomolecules as Permeation Pores2019

    • Author(s)
      佐伯大輔
    • Journal Title

      MEMBRANE

      Volume: 44 Issue: 1 Pages: 22-26

    • DOI

      10.5360/membrane.44.22

    • NAID

      130007594091

    • ISSN
      0385-1036, 1884-6440
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体膜を模倣した水処理膜2018

    • Author(s)
      佐伯大輔
    • Journal Title

      生物工学

      Volume: 96 Pages: 538-538

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Formation of supported lipid bilayers on porous polymeric substrates induced by hydrophobic interaction2018

    • Author(s)
      W. Miyashita, D. Saeki, H. Matsuyama
    • Journal Title

      Colloids and Surfaces A: Physicochemical and Engineering Aspects

      Volume: 538 Pages: 297-303

    • DOI

      10.1016/j.colsurfa.2017.11.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] アニオン性表面への支持脂質二分子膜の形成に関する検討2020

    • Author(s)
      両頭佳佑, 佐伯大輔, 奥村幸久
    • Organizer
      第22回化学工学会学生発表会(東京大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 静電相互作用を用いたリポソーム融合法におけるSLB形成挙動に及ぼす脂質組成と融合誘発剤の影響2020

    • Author(s)
      谷河怜, 佐伯大輔, 奥村幸久
    • Organizer
      日本膜学会第41年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] AmphotericinBを透過孔とした生体模倣型逆浸透膜の製膜条件が透水性能に及ぼす影響2019

    • Author(s)
      清明充, 佐伯大輔, 奥野健太, 川勝孝博, 藤村侑, 松山秀人
    • Organizer
      日本膜学会第40年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Fabrication of biomimetic water purification membrane with Amphotericin B as a permeating pore2019

    • Author(s)
      A. Seimei, D. Saeki, K. Okuno, T. Kawakatsu, Y. Fujimura, H. Matsuyama
    • Organizer
      The 12th International conference of the Aseanian Membrane Society (AMS12)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体膜を模倣した逆浸透膜の開発2019

    • Author(s)
      佐伯大輔
    • Organizer
      第2回COI学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effect of an amount of lipids on water permeability of supported lipid bilayers with Amphotericin B as a permeating pore2019

    • Author(s)
      A. Seimei, D. Saeki, T. Kawakatsu, Y. Fujimura, H. Matsuyama
    • Organizer
      18th Asian Pacific Confederation of Chemical Engineering Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リポソーム融合法による生体模型水処理膜の作製におけるリポソーム濃度の影響2019

    • Author(s)
      清明充, 佐伯大輔, 川勝孝博, 藤村侑, 松山秀人
    • Organizer
      膜シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Gramicidin Aを透過孔に用いた生体模倣型逆浸透膜の開発2019

    • Author(s)
      佐伯大輔, 奥野健太, 川勝孝博, 藤村侑, 松山 秀人
    • Organizer
      日本化学会第99回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂質二分子膜のアルキル鎖長がAmphotericin Bの物質透過性に及ぼす影響2018

    • Author(s)
      佐伯大輔, 高井徹, 熊谷和夫, 松山秀人
    • Organizer
      日本膜学会第40年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Layer-by-Layer法で作製した高分子多重層表面への脂質二分子膜形成における高分子種の影響2018

    • Author(s)
      清明充, 佐伯大輔, 奥野健太, 松山秀人
    • Organizer
      日本膜学会第40年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Fabrication of biomimetic reverse osmosis membrane using a phospholipid bilayer and gramicidin A via electrostatic interaction2018

    • Author(s)
      Daisuke Saeki, Kenta Okuno, Takahiro Kawakatsu, Yu Fujimura, Hideto Matsuyama
    • Organizer
      The 11th Conference of Aseanian Membrane Society (AMS11)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ナノ細孔を有する支持体を用いた生体膜模倣型逆浸透膜の開発2018

    • Author(s)
      奥野健太, 佐伯大輔, 川勝孝博, 藤村侑, 松山 秀人
    • Organizer
      化学工学会第50回秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Amphotericin Bを透過孔とした生体模倣型逆浸透膜におけるチャネル組成が透水性に及ぼす影響2018

    • Author(s)
      清明充, 佐伯大輔, 奥野健太, 川勝孝博, 藤村侑, 松山秀人
    • Organizer
      化学工学会第50回秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生体膜の模倣による水処理膜の高機能化2018

    • Author(s)
      佐伯大輔
    • Organizer
      信州大学工学部コロイド&界面科学研究センター第4回(2018年)研究討論会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 高い耐圧性を有するナノ細孔を持つ支持体を用いた生体膜模倣型逆浸透膜の開発2018

    • Author(s)
      奥野健太, 佐伯大輔, 川勝孝博, 藤村侑, 松山 秀人
    • Organizer
      膜シンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生体模倣型分離膜におけるAmphotericin Bチャネルの組成が透水性能に及ぼす影響2018

    • Author(s)
      清明充, 佐伯大輔, 奥野健太, 川勝孝博, 藤村侑, 松山秀人
    • Organizer
      膜シンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Fabrication of biomimetic reverse osmosis membranes composed of a lipid bilayer, gramicidin A, and nanoporous supports2018

    • Author(s)
      Daisuke Saeki, Kenta Okuno, Takahiro Kawakatsu, Yu Fujimura, Hideto Matsuyama
    • Organizer
      第28回日本MRS年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] リポソーム膜中の環状ペプチド会合体による水チャネル形成2018

    • Author(s)
      岩井崇,本村稔季,通阪栄一,鈴木祐麻,比嘉充,佐伯大輔,松山秀人
    • Organizer
      第28回日本MRS年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Layer-by-layer法を用いたナノ濾過膜の作製における高分子種の透水性への影響2018

    • Author(s)
      清明充, 佐伯大輔, 奥野健太, 松山秀人
    • Organizer
      第20回化学工学会学生発表会(広島大会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 鎖長の異なる脂質二分子膜におけるAmphotericin Bの水/イオン透過性評価2018

    • Author(s)
      高井徹, 佐伯大輔, 熊谷和夫, 松山秀人
    • Organizer
      化学工学会第83年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 重合性脂質により構成される脂質二分子膜の膜構造評価2017

    • Author(s)
      奥野健太, 佐伯大輔, 松山秀人
    • Organizer
      日本膜学会第39年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 水処理膜を指向したAmphotericin Bのリン脂質二分子膜中での物質透過性評価2017

    • Author(s)
      高井徹, 佐伯大輔, 熊谷和夫, 松山秀人
    • Organizer
      日本膜学会第39年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Characterization of membrane performance of supported lipid bilayers incorporating amphotericin B as water channels2017

    • Author(s)
      T. Takai, D. Saeki, K. Kumagai, H. Matsuyama
    • Organizer
      2017 International Congress on Membranes and Membrane Processes (ICOM2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アルキル化多孔体を支持体とした平面脂質二分子膜の形成と物質透過性評価2017

    • Author(s)
      佐伯大輔, 高井徹, 迫郁弥, 松山秀人
    • Organizer
      第68回コロイドおよび界面化学討論会
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 選択性透過膜の製造方法および水処理方法2019

    • Inventor(s)
      佐伯大輔、他
    • Industrial Property Rights Holder
      信州大学、他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-126965
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 選択性透過膜、選択性透過膜の製造方法および水処理方法2019

    • Inventor(s)
      佐伯大輔、他
    • Industrial Property Rights Holder
      信州大学、他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-126966
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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