| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
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| Outline of Final Research Achievements |
To quantify a variety of synaptic changes, we established a semi-automated technique for quantifying synapses on the photoreceptor axons (J. Vis. Exp., 2017). By developing this method, we found that synaptic loss occurred before neurodegeneration and that the divergent canonical WNT pathway is involved in maintaining the neuronal circuit. Based on the results of a series of synapse studies, we have published a review that summarizes the phenomena and mechanisms by which synaptic structure is functionally changed by neural activity (Neural Dev., 2018). We also established a recording system for individual activity in Drosophila and described circadian rhythms during stress in a constant light environment that induced degeneration of the photoreceptor axons (Sci. Rep., 2019).
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