| Budget Amount *help |
¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
We succeeded in reproducing Repeat Associated Non-AUG translation, which is an irregular protein translation depends on CAG repeat sequences that cause human neurodegenerative diseases using a reconstituted protein synthesis system constructed with purified human translation factors. These results indicating that the translation reactions that cause neurodegenerative diseases occur if there is a translation-related factors such as mRNA, ribosome, translation initiation factors, translation elongation factors, and translation termination factors. This study established the technical basis for reproducing and analyzing the irregular translation mechanism that causes neurodegenerative diseases in vitro.
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