Study of neural circuit formation regulated by primary cilia
| Project/Area Number |
17H05003
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Kwansei Gakuin University (2019-2020)
Nara Institute of Science and Technology (2017-2018) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2019: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2017: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
|---|
| Keywords | 一次繊毛 / 繊毛病 / 神経成長因子 / 神経回路網形成 / 不飽和脂肪酸 / 軸索ガイダンス / オメガ3脂肪酸 / NFAT / プロスタグランジンE2 |
|---|
| Outline of Final Research Achievements |
In this study, we focused on the identification of extracellular molecules that regulate the formation of primary cilia in neurons and the analysis of intracellular signaling mechanisms. We found that stimulation with nerve growth factor and unsaturated fatty acids such as docosahexaenoic acid promoted the formation of primary cilia in neurons. In addition, we found a new mechanism by which these extracellular stimuli promote the formation of primary cilia by increasing the intracellular calcium concentration, activating the transcription factor NFAT, increasing the expression of COX-2, and producing PGE2.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究ではこれまで理解が進んでいなかった神経細胞の一次繊毛の形成に関わる分子機構が明らかとなった。DHAなどの不飽和脂肪酸は脳機能の記憶/学習能力の向上に関わることが先行研究から明らかとなっているが、その作用機序の全容は定かではない。今回の研究により不飽和脂肪酸が神経細胞の一次繊毛の形成を促進することで、一次繊毛を介したシグナル受容と細胞応答が促進され脳機能の向上に関与する可能性が示唆された。
|
Report
(4 results)
Research Products
(16 results)
-
-
-
[Journal Article] Grip and slip of L1-CAM on adhesive substrates direct growth cone haptotaxis. Proc. Natl.2018
Author(s)
Abe, K., Katsuno, H., Toriyama, M., Baba, K., Mori, T., Hakoshima, T., Kanemura, Y., Watanabe, R. and Inagaki, N.
-
Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 115
Issue: 11
Pages: 2764-2769
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
