| Budget Amount *help |
¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2019: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2017: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Outline of Final Research Achievements |
In this study, we focused on the identification of extracellular molecules that regulate the formation of primary cilia in neurons and the analysis of intracellular signaling mechanisms. We found that stimulation with nerve growth factor and unsaturated fatty acids such as docosahexaenoic acid promoted the formation of primary cilia in neurons. In addition, we found a new mechanism by which these extracellular stimuli promote the formation of primary cilia by increasing the intracellular calcium concentration, activating the transcription factor NFAT, increasing the expression of COX-2, and producing PGE2.
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