Analysis of spatio-temporal regulation of multipotent stem cells
| Project/Area Number |
17H05008
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Kobe University (2019)
The University of Tokyo (2017-2018) |
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Principal Investigator |
Kondo Yuki 神戸大学, 理学研究科, 准教授 (70733575)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2017: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
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| Keywords | 幹細胞 / 細胞運命 / 時空間制御 / 維管束 / 細胞分化 / 多能性 / 構成生物学 / 発生・分化 / 植物 / 細胞・組織 |
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| Outline of Final Research Achievements |
In this project, we aimed to reveal spatio-temporal regulation of vascular stem cells. Based on deep-tissue imaging in a tissue culture system VISUAL, we found out that adaxial-abaxial polarity of the leaf is important for specifying xylem or phloem cell fates (Nurani et al., 2020, PCP). On the other hand, genetic screen identified two novel genes that promote vascular stem cell differentiation in VISUAL. Interestingly, one of them encoded a circadian clock-related protein. These results suggest the potential role of spatial and temporal information in vascular stem cell fate determination. Moreover, we found factors involved in this process, which will lead to further understanding of plant multi-potent stem cells.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題では、維管束幹細胞の運命決定制御機構の解析をおこない、位置情報と時間情報の重要性を明らかにすることができた。実際に、位置情報に関わるあるホルモンの量をコントロールすることで維管束幹細胞の運命を操作することができるようになった。このように、幹細胞制御に関する知見が広がり研究が進展していくことで、今後、維管束を構成する様々な機能細胞を自在に創出することができるようになると期待される。
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Lateral inhibition by a peptide hormone-receptor cascade during Arabidopsis lateral root founder cell formation.2019
Author(s)
Toyokura K, Goh T, Shinohara H, Shinoda A, Kondo Y, Okamoto Y, Uehara T, Fujimoto K, Okushima Y, Ikeyama Y, Nakajima K, Mimura T, Tasaka M, Matsubayashi Y and Fukaki H.
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Journal Title
Developmental Cell
Volume: 48
Issue: 1
Pages: 64-75
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] WIND1 has a potential to orchestrate pleiotropic responses after wounding2020
Author(s)
Akira Iwase, Yuki Kondo, Anuphon Laohavisit, Arika Takebayashi, Momoko Ikeuchi, Keita Matsuoka, Masashi Asahina, Nobutaka Mitsuda, Ken Shirasu, Hiroo Fukuda, Keiko Sugimoto
Organizer
第61回日本植物生理学会年会
Related Report
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[Presentation] BES/BZR 転写因子の競争的な関係が幹細胞維持の堅牢性を向上させる2020
Author(s)
古谷朋之,齊藤真人,内村悠,野﨑翔平,宮川拓也,佐竹暁子,島津舜治,矢守航,田之倉優,福田裕穂,近藤侑貴
Organizer
第61回日本植物生理学会年会
Related Report
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