• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of abscisic acid signaling pathway by chemical genetic analysis

Research Project

Project/Area Number 17H05009
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Plant molecular biology/Plant physiology
Research InstitutionUtsunomiya University

Principal Investigator

Okamoto Masanori  宇都宮大学, バイオサイエンス教育研究センター, 准教授 (50455333)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2020: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywordsアブシシン酸 / 植物ホルモン / 受容体 / アゴニスト / シロイヌナズナ / コムギ / 乾燥ストレス / 植物生理学 / 分子生物学 / ケミカルバイオロジー / アンタゴニスト / シグナル伝達 / 寄生植物 / アブシジン酸 / 乾燥 / ストレス応答
Outline of Final Research Achievements

Abscisic acid (ABA) receptors form a larger gene family than other phytohormone receptors. Although plants are exposed to various environmental stresses on land, the emergence of many ABA receptors is thought to have achieved the prosperity of angiosperms. ABA receptors are classified into monomeric types (subclasses I and II) with high affinity and dimeric types with low affinity (subclass III) for ABA. However, physiological functions of these abscisic acid (ABA) receptors have not been revealed well. Through the development of subtype-specific mutants and receptor-selective agonists, it was suggested that dimeric receptors play a major role in both drought stress response and growth regulation, whereas monomeric receptors support ABA action with dimeric receptors. Coordinate action of these receptors contributes to plant robustness in complex stress environments.

Academic Significance and Societal Importance of the Research Achievements

植物が獲得した初期のABA受容体はABAに対して親和性が高く、このタイプの受容体は環境ストレスに応じて変動するABAのシグナル強度を十分に活用できないものであったと推測される。進化の過程で、被子植物がABA受容体のABAに対する親和性を低下させたことで、様々な環境ストレスに応じて変動するABAをストレスシグナル分子として利用できるようになり、その結果、変動する環境下でも柔軟に適応して生存する能力を獲得したと推測される。本研究成果は、ABA受容体を低親和性に改良することで、振れ幅の大きい環境にも柔軟に耐えうる作物創出の可能性を提案するものである。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (38 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (20 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 14 results,  Open Access: 4 results) Presentation (16 results) (of which Int'l Joint Research: 3 results,  Invited: 7 results) Remarks (2 results)

  • [Journal Article] Ligand-receptor interactions in plant hormone signaling2021

    • Author(s)
      Takeuchi Jun、Fukui Kosuke、Seto Yoshiya、Takaoka Yousuke、Okamoto Masanori
    • Journal Title

      The Plant Journal

      Volume: 105 Issue: 2 Pages: 290-306

    • DOI

      10.1111/tpj.15115

    • NAID

      120006941098

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 寄生植物ストライガの養水分奪取機構の解明2020

    • Author(s)
      岡本昌憲,藤岡聖,杉本幸裕
    • Journal Title

      KAGAKU TO SEIBUTSU

      Volume: 58 Issue: 3 Pages: 138-140

    • DOI

      10.1271/kagakutoseibutsu.58.138

    • NAID

      130007992996

    • ISSN
      0453-073X, 1883-6852
    • Year and Date
      2020-03-01
    • Related Report
      2019 Annual Research Report
  • [Journal Article] アブシシン酸受容体の利用による節水性と耐乾性を兼ね備えたコムギの開発2020

    • Author(s)
      妻鹿 良亮、岡本昌憲
    • Journal Title

      植物の生長調節

      Volume: 155 Pages: 126-130

    • NAID

      130008131341

    • Related Report
      2020 Annual Research Report
  • [Journal Article] フィールドにおける生命現象の解明とその制御に向けた基盤技術の創出2020

    • Author(s)
      山内卓樹、藤井壮太、岡本昌憲、田中佑、水多陽子、晝間敬、吉田健太郎、山本英司、大西孝幸、犬飼義明
    • Journal Title

      育種学研究

      Volume: 22 Pages: 75-82

    • NAID

      130007869255

    • Related Report
      2020 Annual Research Report
  • [Journal Article] アブシシン酸アゴニストの理論設計2020

    • Author(s)
      岡本昌憲、竹内純、轟泰司
    • Journal Title

      植物の生長調節

      Volume: 155 Pages: 40-45

    • NAID

      130008060507

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 寄生植物ストライガの養水分奪取機構の解明2020

    • Author(s)
      岡本昌憲、 藤岡聖、 杉本幸裕
    • Journal Title

      化学と生物

      Volume: 158 Pages: 138-140

    • Related Report
      2020 Annual Research Report
  • [Journal Article] How dose Striga hermonthica bewitch its hosts?2019

    • Author(s)
      Hijiri Fujioka, Hiroaki Samejima, Masaharu Mizutani, Masanori Okamoto, Yukihiro Sugimoto
    • Journal Title

      Plant Signaling & Behavior

      Volume: 14 Issue: 7 Pages: 1-2

    • DOI

      10.1080/15592324.2019.1605810

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic manipulation of abscisic acid receptors enables modulation of water use efficiency.2019

    • Author(s)
      Mega R. Tsujimoto H. Okamoto M.
    • Journal Title

      Plant Signaling & Behavior

      Volume: 14 Issue: 10 Pages: e1642039-e1642039

    • DOI

      10.1080/15592324.2019.1642039

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic control of plant water use using designed ABA receptor agonists2019

    • Author(s)
      Vaidya AS. Helander JDM. Peterson FC. Elzinga D. Dejonghe W. Kaundal A. Park SY. Xing Z. Mega R. Takeuchi J. Khanderahoo B. Bishay S. Volkman BF. Todoroki Y. Okamoto M. Cutler SR.
    • Journal Title

      Science

      Volume: 366 Issue: 6464

    • DOI

      10.1126/science.aaw8848

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tuning water-use efficiency and drought tolerance in wheat using abscisic acid receptors2019

    • Author(s)
      Ryosuke Mega, Fumitaka Abe, June-Sik Kim, Yuuri Tsuboi, Keisuke Tanaka, Hisato Kobayashi, Yoichi Sakata, Kousuke Hanada, Hisashi Tsujimoto, Jun Kikuchi, Sean R. Cutler & Masanori Okamoto
    • Journal Title

      Nature Plants

      Volume: 5 Issue: 2 Pages: 153-159

    • DOI

      10.1038/s41477-019-0361-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Aberrant protein phosphatase 2C leads to ABA insensitivity and high transpiration in parasitic Striga2019

    • Author(s)
      Hijiri Fujioka, Hiroaki Samejima, Hideyuki Suzuki, Masaharu Mizutani, Masanori Okamoto, Yukihiro Sugimoto
    • Journal Title

      Nature Plants

      Volume: 5 Issue: 3 Pages: 258-262

    • DOI

      10.1038/s41477-019-0362-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-Based Chemical Design of Abscisic Acid Antagonists That Block PYL?PP2C Receptor Interactions2018

    • Author(s)
      Takeuchi Jun、Mimura Naoki、Okamoto Masanori、Yajima Shunsuke、Sue Masayuki、Akiyama Tomonori、Monda Keina、Iba Koh、Ohnishi Toshiyuki、Todoroki Yasushi
    • Journal Title

      ACS Chemical Biology

      Volume: 13 Issue: 5 Pages: 1313-1321

    • DOI

      10.1021/acschembio.8b00105

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AtPep3 is a hormone-like peptide that plays a role in the salinity stress tolerance of plants2018

    • Author(s)
      Nakaminami Kentaro、Okamoto Masanori、Higuchi-Takeuchi Mieko、Yoshizumi Takeshi、Yamaguchi Yube、Fukao Yoichiro、Shimizu Minami、Ohashi Chihiro、Tanaka Maho、Matsui Minami、Shinozaki Kazuo、Seki Motoaki、Hanada Kousuke
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 22 Pages: 5810-5815

    • DOI

      10.1073/pnas.1719491115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conversion of carlactone to carlactonoic acid is a conserved function of MAX1 homologs in strigolactone biosynthesis.2018

    • Author(s)
      Yoneyama K, Mori N, Sato T, Yoda A, Xie X, Okamoto M, Iwanaga M, Ohnishi T, Nishiwaki H, Asami T, Yokota T, Akiyama K, Yoneyama K, Nomura T.
    • Journal Title

      New Phytol.

      Volume: 218 Issue: 4 Pages: 1522-1533

    • DOI

      10.1111/nph.15055

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Small Molecule Probes of ABA Biosynthesis and Signaling2018

    • Author(s)
      Dejonghe Wim、Okamoto Masanori、Cutler Sean R
    • Journal Title

      Plant and Cell Physiology

      Volume: 59 Issue: 8 Pages: 1490-1499

    • DOI

      10.1093/pcp/pcy126

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemical Control of ABA Receptors to Enable Plant Protection Against Water Stress2018

    • Author(s)
      Okamoto Masanori、Cutler Sean R.
    • Journal Title

      Plant Chemical Genomics

      Volume: - Pages: 127-141

    • DOI

      10.1007/978-1-4939-7874-8_11

    • ISBN
      9781493978731, 9781493978748
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Novel biotin linker with alkyne and amino groups for chemical labelling of a target protein of a bioactive small molecule2018

    • Author(s)
      omoaki Anabuki, Miu Tsukahara, Masanori Okamoto, Hideyuki Matsuura, Kosaku Takahashi
    • Journal Title

      Bioorganic & medicinal chemistry letters

      Volume: 28 Issue: 4 Pages: 783-786

    • DOI

      10.1016/j.bmcl.2017.12.055

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient anchoring of alien chromosome segments introgressed into bread wheat by new Leymus racemosus genome-based markers2018

    • Author(s)
      Edet Offiong Ukpong、Kim June-Sik、Okamoto Masanori、Hanada Kousuke、Takeda Tomoyuki、Kishii Masahiro、Gorafi Yasir Serag Alnor、Tsujimoto Hisashi
    • Journal Title

      BMC Genetics

      Volume: 19 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s12863-018-0603-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNA-Seq using bulked recombinant inbred line populations uncovers the importance of brassinosteroid for seed longevity after priming treatments2017

    • Author(s)
      Naoto Sano, June-Sik Kim, Yoshihiko Onda, Takahito Nomura, Keiichi Mochida, Masanori Okamoto, Mitsunori Seo
    • Journal Title

      Scientific reports

      Volume: 14 Issue: 1 Pages: 8095-8095

    • DOI

      10.1038/s41598-017-08116-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Highly Specific Genome-Wide Association Study Integrated with Transcriptome Data Reveals the Contribution of Copy Number Variations to Specialized Metabolites in Arabidopsis thaliana Accessions2017

    • Author(s)
      Kazumasa Shirai, Fumio Matsuda, Ryo Nakabayashi, Masanori Okamoto, Maho Tanaka, Akihiro Fujimoto, Minami Shimizu, Kazuo Shinozaki, Motoaki Seki, Kazuki Saito, Kousuke Hanada
    • Journal Title

      Molecular biology and evolution

      Volume: 34 Issue: 12 Pages: 3111-3122

    • DOI

      10.1093/molbev/msx234

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Tuning water use efficiency and drought tolerance in wheat using abscisic acid receptors2021

    • Author(s)
      Okamoto M.
    • Organizer
      International Workshop on Optics, Biology, and Related Technologies
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 植物の乾燥ストレス応答を制御する分子開発2021

    • Author(s)
      岡本昌憲
    • Organizer
      第46回日本農薬学会シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 多様なアブシシン酸受容体の生理機能の解明を目指した人工分子の開発と利用2021

    • Author(s)
      岡本昌憲
    • Organizer
      第62回 日本植物生理学会シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] シロイヌナズナにおけるアブシシン酸不活性化鍵酵素の機能解析.2020

    • Author(s)
      宮田百華, 妻鹿良亮, 金俊植, 瀬尾光範, 南原英司, 岡本昌憲
    • Organizer
      第61回日本植物生理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Tuning water use efficiency and drought tolerance in wheat using ABA receptors2019

    • Author(s)
      Okamoto M
    • Organizer
      23th The International Plant Growth Substances Association Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アブシシン酸感受性の向上によるコムギの水利用効率と耐乾性の改良2019

    • Author(s)
      岡本昌憲
    • Organizer
      第61回日本育種学会シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Functional analysis of Arabidopsis CYP707As, which encode key enzymes for ABA catabolism.2019

    • Author(s)
      Miyata M., Mega R., Kim JK., Seo M., Nambara E., Okamoto M.
    • Organizer
      23th The International Plant Growth Substances Association Conference
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生植物ストライガのアブシシン酸シグナル伝達因子の機能解析.2019

    • Author(s)
      福原大晶、藤岡 聖、杉本幸裕、岡本昌憲
    • Organizer
      植物化学調節学会第54回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アブシシン酸受容体がもたらすコムギ病害抵抗性機構の解析.2019

    • Author(s)
      嶋崎太一、金俊植、妻鹿良亮、安倍史高、山根久和、吉田健太郎、岡本昌憲
    • Organizer
      植物化学調節学会第54回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] コムギのアブシシン酸受容体過剰発現による光合成速度の促進.2019

    • Author(s)
      妻鹿良亮、安倍史高、金俊植、田中啓介、小林久人、坂田洋一、辻本壽、岡本昌憲
    • Organizer
      植物化学調節学会第54回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] シロイヌナズナにおけるアブシシン酸不活性化鍵酵素の機能解析.2019

    • Author(s)
      宮田百華、妻鹿良亮、金俊植、瀬尾光範、南原英司、岡本昌憲
    • Organizer
      植物化学調節学会第54回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゲノム編集を利用したアブシシン酸受容体サブファミリータイプ別多重変異株の作成.2019

    • Author(s)
      岡本昌憲、嶋﨑太一
    • Organizer
      植物化学調節学会第54回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アブシジン酸受容体を利用したコムギの水利用効率と耐乾性の改良2019

    • Author(s)
      岡本昌憲,安倍史高,菊地淳,妻鹿亮介
    • Organizer
      第60回 日本植物生理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 植物ホルモンアブシジン酸の生理作用を制御する化合物開発と利用2018

    • Author(s)
      岡本 昌憲
    • Organizer
      新学術領域「分子夾雑の生命化学」関東地区シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アブシジンの生理作用を制御する化合物開発と利用2018

    • Author(s)
      岡本 昌憲
    • Organizer
      第57回 日本植物生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] "Chemical regulation in ABA metabolism and signaling"2017

    • Author(s)
      Okamoto Masanori
    • Organizer
      "ISHS 13th International Symposium on Plant Bioregulators in Fruit Production "
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 干ばつに強く、水を節約して育つコムギの開発に成功

    • URL

      https://www.jst.go.jp/pr/announce/20190209/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 食糧生産に甚大な被害をもたらす寄生植物ストライガの養水分収奪機構を解明

    • URL

      https://www.jst.go.jp/pr/announce/20190226/index.html

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi