| Budget Amount *help |
¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Outline of Final Research Achievements |
Neurons transmit information via synaptic vesicles that are localized in the axon. Synaptic vesicles are synthesized only in the cell body and transported down to the axon by a transport mechanism called axonal transport. In this work, we have shown that axonal transport is regulated by a molecular cascade consisting of BLOC-1 related complex (BORC), small GTPase ARL-8 and a molecular motor KIF1A. BORC activates ARL-8 by converting ARL-8(GDP) to ARL-8(GTP). ARL-8(GTP) binds to KIF1A and unlock the autoinhibition. Activated KIF1A binds to axonal transport carriers and transport them.
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