Analysis of neuronal mechanisms for flight control
Project/Area Number |
17H05011
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Animal physiology/Animal behavior
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Research Institution | The University of Tokyo |
Principal Investigator |
Namiki Shigehiro 東京大学, 先端科学技術研究センター, 准教授 (40567757)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
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Keywords | はばたき / 神経行動学 / 光遺伝学 / 飛翔神経叢 / Split-GAL4 / ハルテア神経叢 / 神経回路 / 飛行回路 / Spllit-GAL4 / ニューロンデータベース / 飛行制御 / 飛翔 / コマンド / 飛行ニューロン / GAL4 / ショウジョウバエ / コネクトーム / 飛翔筋 / 下行性ニューロン / 小型飛翔体 |
Outline of Final Research Achievements |
In animals, behavior is controlled by a group of descending neurons that connect the brain to the body. In this study, we focused on DNg02, descending neuron that have been shown to play an important role in flight control in Drosophila, and analyzed it in detail using molecular genetics, optogenetics, optophysiology, and neuroanatomy. DNg02 is a population of cells with similar morphological features to each other, each with the ability to drive flapping motion. The intensity of flapping increased with the number of active cells, suggesting that DNg02 encodes flapping commands collectively.
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Academic Significance and Societal Importance of the Research Achievements |
本研究は脳から身体へ発し、飛行を司令する細胞を初めての報告となる。昆虫は神経行動学の重要なモデル生物であるが、これまでの事例からは単一の下行性ニューロンが単一の行動を駆動するという考え方が一般的であった。本研究では飛行という行動が複数のニューロンによって制御されていることを示した点において、学術的な意義がある。また本研究において開発した神経細胞を選択的に標識する遺伝学的リソースは、神経科学研究のために有用であり、今後研究コミュニティに広く用いられると期待される。
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] A Systematic Nomenclature for the Drosophila Ventral Nerve Cord.2020
Author(s)
Court R, Namiki S, Armstrong D, Borner J, Card G, Costa M, Dickinson MH, Duch C, Korff W, Mann R, Merritt D, Murphey R, Seeds A, Shirangi T, Simpson J, Truman J, Tuthill J, Williams D, Shepherd D
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Journal Title
Neuron
Volume: 107
Issue: 6
Pages: 1071-1079
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Neural circuit basis of aversive odour processing in Drosophila from sensory input to descending output2020
Author(s)
Huoviala P, Dolan MJ, Love FM, Myers P, Frechter S, Namiki S, Pettersson L, Roberts RJV, Turnbull R, Mitrevica Z, Breads P, Schlegel P, Bates AS, Rodrigues T, Aso Y, Bock D, Rubin GM, Stensmyr M, Card G, Costa M, Jefferis GSXE
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Journal Title
bioRxiv
Volume: 394403
Pages: 1-16
DOI
Related Report
Open Access / Int'l Joint Research
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[Journal Article] An image resource of subdivided Drosophila GAL4-driver expression patterns for neuron-level searches2020
Author(s)
Meissner GW, Dorman Z, Nern A, Forster K, Gibney T, Jeter J, Lohnson L, He Y, Lee K, Melton B, Yarbrough B, Clements J, Goina C, Otsuna H, Rokicki K, Svirskas RR, Aso Y, Card GM, Dickson BJ, Ehrhardt E, Goldammer J, Ito M, Korff W, Minegishi R, Namiki S, Rubin GM, Sterne G, Wolff T, Malksman O
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Journal Title
bioRxiv
Volume: 080473
Pages: 1-16
DOI
Related Report
Open Access / Int'l Joint Research
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[Journal Article] A Systematic Nomenclature for the DrosophilaVentral Nervous System2017
Author(s)
Court Robert Christopher、Armstrong James Douglas、Borner Jana、Card Gwyneth、Costa Marta、Dickinson Michael、Duch Carsten、Korff Wyatt、Mann Richard、Merritt David、Murphey Rod、Namiki Shigehiro、Seeds Andrew、Shepherd David、Shirangi Troy、Simpson Julie、Truman James、Tuthill John、Williams Darren
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Journal Title
bioRxiv
Volume: N/A
Pages: 1-42
DOI
Related Report
Open Access / Int'l Joint Research
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[Presentation] A cell-type specific driver line library targeting motoneurons and interneurosn in the wing neuropil of the ventral nerve cord of Drosophila melanogaster2019
Author(s)
Ehrchardt E, Whitehead S, Namiki S, Siwanowicz I, Otsuna H, Stern D, Dickinson M, Ito K, Truman J, Cohen I, Korff W, Card GM
Organizer
13th Gottingen Meeting of the German Neuroscience Society
Related Report
Int'l Joint Research
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[Presentation] Ache JM, Namiki S, von Reyn CR, Card GM2019
Author(s)
Feature detection and action selection in neuronal circuits for escape and and landing Drosophila
Organizer
13th Gottingen Meeting of the German Neuroscience Society, Centre for Humanities, Gottingen, Germany
Related Report
Int'l Joint Research
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[Presentation] A cell-type specific driver line library targeting motoneurons and interneurosn in the wing neuropil of the ventral nerve cord of Drosophila melanogaster2019
Author(s)
Ehrchardt E, Whitehead S, Namiki S, Siwanowicz I, Otsuna H, Stern D, Dickinson M, Ito K, Truman J, Cohen I, Korff W, Card GM
Organizer
13th Gottingen Meeting of the German Neuroscience Society, Centre for Humanities, Gottingen, Germany
Related Report
Int'l Joint Research
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[Presentation] Innate freezing behavior, triggered by P9 descending neurons, is plastic2018
Author(s)
Zacarias R, Ferreira C, Vieira R, Namiki S, Card G, Vasconcelos ML, Moita MA
Organizer
Janelia Conference "Neural Circuits of the Insect Ventral Nerve Cord", HHMI Janelia Research Campus, VA USA
Related Report
Int'l Joint Research / Invited
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[Presentation] Optogenetic activation of wing motoneurons of Drosophila melanogaster in flight and courtship song2018
Author(s)
Ehrhardt EE, Namiki S, Whitehead S, Truman J, Dickinson M, Cohen I, Stern D, Korff W, Card GM
Organizer
Janelia Conference "Neural Circuits of the Insect Ventral Nerve Cord", HHMI Janelia Research Campus, VA USA
Related Report
Int'l Joint Research
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[Presentation] Comparative Neuroscience Platform: the environment for the comparative neuroscience by facilitating data analysis and collaborations through neuroinformatics2017
Author(s)
Kazawa T, Miyamoto D, Seki Y, Yosida M, Iwatsuki C, Ando N, Namiki S, Ikeno H, Nishino H, Oota S, Murata, Kanazawa A, Ichiishi H, Kanamoto Y, Yamaguchi Y, Kanzaki R
Organizer
Advances in Neuroinformatics 2017
Related Report
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[Presentation] Developing comparative neuroscience platform (CNS-PF): the environment for facilitating data analysis and collaborations on comparative neuroinformatics2017
Author(s)
Kazawa T, Miyamoto D, Seki Y, Yoshida M, Iwatsuki C, Ando N, Namiki S, Ikeno H, Nishino H, Oota S, Murata Y, Kanazawa A, Ichiishi H, Kanamoto Y, Yamaguchi Y, Kanzaki R
Organizer
The 39th Annual Meeting of the Japanese Society for Comparative Physiology and Biochemistry
Related Report
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[Book] 昆虫の脳をつくる2018
Author(s)
神崎亮平
Total Pages
224
Publisher
朝倉書店
ISBN
9784254102772
Related Report
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[Book] 動物学の百科事典2018
Author(s)
公益社団法人日本動物学会
Total Pages
800
Publisher
丸善出版
ISBN
9784621303092
Related Report
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