| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2017: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
|
|---|
| Outline of Final Research Achievements |
We investigated the physiological role of the metabolism of cyclopentenone-prostaglandin, mediated by prostaglandin-conjugating enzymes, sulfotransferase and glutathione transferase, in the intestinal tract. As a result, the prostaglandin metabolites negatively regulated the prostaglandin receptors involved in inflammation and cancer and suppressed the expression of inflammatory cytokines. In addition, the effects of prostaglandin-conjugating enzymes knockdown on the inflammatory cytokine expression was confirmed by in vivo knockdown experiments, implying that prostaglandin-conjugating enzymes may play a role in the regulating the intestinal immune system. Furthermore, this study suggested that the conjugation enzymes regulate the homeostasis of villi by controlling the apoptotic action of prostaglandin peroxide metabolites.
|
