| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
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| Outline of Final Research Achievements |
The brown adipose tissue is a specialized organ that produce heat by burning fat and sugar in mammals. In this study, we investigated whether Apobec2 regulates energy metabolism in brown adipose tissue. Apobec2-/- mice showed reduced white adipose tissue and smaller lipid droplets in brown adipose tissue compared with WT littermates. Furthermore, Apobec2-/- mice showed increased energy expenditure and lipid metabolism with altered mitochondrial morphology, mitochondrial depolarization and marker protein expression. This might be due to the higher activation of BAT thermogenesis under cold exposure compared with WT littermates. In addition, Apobec2 deficiency ameliorated high fat diet-induced lipid accumulation in liver and metabolic disorder. Our findings indicate the possibility of energy metabolism regulation by Apobec2 in brown adipose tissue.
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