Study of the association between influenza D virus and bovine respiratory distress syndrome.
Project/Area Number |
17H05042
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
Veterinary medical science
|
Research Institution | The University of Tokyo |
Principal Investigator |
Murakami Shin 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10636757)
|
Project Period (FY) |
2017-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2017: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
Keywords | D型インフルエンザウイルス / 牛呼吸器病症候群 / リバースジェネティクス / D型インフルエンザ / ウシ呼吸器病症候群 / ウシ呼吸器病 / 牛呼吸器病 |
Outline of Final Research Achievements |
To investigate the epidemiological status of influenza D virus infection in cattle in Japan, we detected a strain of influenza D virus in Japan that was phylogenetically different from the previously reported strains of influenza D virus. Furthermore, we isolated this new virus and we found that the new strain was antigenicity different from previously known strains. We also successfully developed a reverse genetics system of influenza D virus, which is an important tool for analyzing viral properties. Furthermore, using this reverse genetics system, we succeeded in producing an 8-segmented virus.
|
Academic Significance and Societal Importance of the Research Achievements |
分離した日本株の独自性についての知見は、ワクチン開発におけるウイルス株選択の重要性を示している。また確立したD型インフルエンザウイルスの最適化したリバースジェネティクス技術は、任意のゲノム改変技術として、例えば、変異ウイルスを用いたウイルス増殖過程の解析やウイルス抗原性の解析などに活用できる。さらに、本技術は、呼吸器感染症であるD型インフルエンザのワクチン開発において、感染防御能をもつ粘膜抗体を誘導できる理想的な弱毒生ワクチン株の作出を可能にすることで、世界中で被害を及ぼしているBRDCの制御に大きく貢献することが期待される。
|
Report
(5 results)
Research Products
(23 results)
-
-
-
-
[Journal Article] Antigenic heterogeneity among phylogenetic clusters of influenza D viruses2018
Author(s)
Odagiri T, Ishida H, Li J-Y, Endo M, Kobayashi T, Kamiki H, Matsugo H, Takenaka-Uema A, Murakami S, Horimoto T.
-
Journal Title
Journal of Veterinary Medical Science
Volume: 80
Issue: 8
Pages: 1241-1244
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Sero-surveillamce of influenza D virus infection in cattle2017
Author(s)
Tomoha Odagiri, Hiroho Ishida, Junyou Li, Maiko, Endo, Akiko Uema, Takeshi Haga, Tsuneyuki Masuda, Takashi Ohmori, Akihiro Tazumi, Osamu Taira, Chihiro Sasakawa, Takashi Yamanaka, Shin Murakami, Taisuke Horimoto
Organizer
第65回日本ウイルス学会学術集会
Related Report