| Budget Amount *help |
¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2019: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2017: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
|---|
| Outline of Final Research Achievements |
In this study, I focused on the interactions between tumor cells and immune cells via extracellular vesicles, exosomes, and investigated the molecular mechanisms involved in chemotherapy resistance in tumors.First, the molecular profiles of exosomes derived from canine lymphoma cells were comprehensively analyzed, and I identified the nucleic acids and proteins whose amounts within exosomes were different between chemotherapy agent-sensitive and resistant cells. In addition, it was suggested that CD82 protein has the functions to suppress the progression of tumors. Furthermore, it was revealed that tumor cell-derived exosomes significantly changed the expression levels of inflammatory cytokines in monocytes and lymphocytes and cell death was induced in cytotoxic T cells.
I believe that these results provided novel insights that contribute to the elucidation of the molecular pathology of neoplastic diseases.
|
