| Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2020: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Mouse primordial germ cells occasionally deviate from the differentiation pathway to sperm and convert into pluripotent cells in the seminiferous tubules, and then variously differentiate to form teratomas. However, the molecular mechanism by which such a phenomenon occurs in vivo is still unknown. We found that a deficiency of the RNA-binding protein Dead end 1 induces the development of testicular teratoma in 129 strain mice. On the other hand, the deficiency of Dead end 1 in the postnatal spermatogenesis process did not cause the development of testicular teratomas and caused a decrease in spermatogonia. From the above, it was shown that the function of Dead end 1 in primordial germ cells is involved in the onset of testis teratoma.
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