| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
Synthetic studies of complex, unique, and challenging structures are important because they create new methodologies. In this study, we have developed a synthetic strategy for a multi-substituted three-membered ring including all-cis substituted cyclopropane, which has not been focused on so far. Based on these originally developed strategies, we have achieved the total synthesis of natural products with complex structures. In particular, the first total syntheses of non-canonical strigolactone, avenaol and lycopodium alkaloid lyconesidine B showing antitumor activity were accomplished. In addition, we have investigated concise synthesis of polycyclic alkaloids, and successfully developed several new synthetic strategies.
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