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Study of Drug Resistance in Cancer Cells to Develop Molecular Target Drugs

Research Project

Project/Area Number 17H05056
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Drug development chemistry
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

Satow Reiko  東京薬科大学, 生命科学部, 講師 (90469966)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsがん / 薬剤耐性 / メラノーマ / ZIC5 / 創薬スクリーニング / スクリーニング
Outline of Final Research Achievements

"Drug resistance" is a major problem that hinders the remission of cancer, and it is necessary to develop a therapeutic method that overcomes drug resistance. So far, the principal investigator has identified a protein that is highly expressed in many types of cancer, and promotes the survival and drug resistance of various cancers. In this research project, we screened for small molecule compounds and found multiple compounds that inhibit the function of this factor. We also identified several proteins that bind to and control this factor.

Academic Significance and Societal Importance of the Research Achievements

本研究課題において、がん特異的に高発現し様々な癌の生存や薬剤耐性を亢進させるタンパク質を阻害する低分子化合物を見出した。この低分子化合物は、メラノーマや薬剤耐性メラノーマに細胞死を誘導したが、正常ヒトメラノサイトや正常ヒトケラチノサイトには細胞死を誘導しなかった。これらのことから、同定した低分子化合物がメラノーマや薬剤耐性メラノーマに有効であると考えられる。また、このタンパク質の制御機構を明らかにすることでさらなる治療薬の開発につながる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (16 results)

All 2020 2019 2018 2017 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (12 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Phosphatidylinositol 4,5-bisphosphate is localized in the plasma membrane outer leaflet and regulates cell adhesion and motility2020

    • Author(s)
      Yoneda A., Kanemaru K., Matsubara A., Takai E., Shimozawa M., Satow R., Yamaguchi H., Nakamura Y., Fukami K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: in press Issue: 4 Pages: 1050-1056

    • DOI

      10.1016/j.bbrc.2020.05.040

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell surface CD63 increased by up-regulated polylactosamine modification sensitizes human melanoma cells to the BRAF inhibitor PLX40322019

    • Author(s)
      Kudo Kohya、Yoneda Atsuko、Sakiyama Daiki、Kojima Kai、Miyaji Takeki、Yamazaki Miku、Yaita Saori、Hyodo Takuya、Satow Reiko、Fukami Kiyoko
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 3 Pages: 3851-3869

    • DOI

      10.1096/fj.201800664rr

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of zinc finger protein of the cerebellum 5 as a survival factor of prostate and colorectal cancer cells.2017

    • Author(s)
      1.Satow R, Inagaki S, Kato C, Shimozawa M, Fukami K.
    • Journal Title

      Cancer Science

      Volume: 108 Pages: 2405-2412

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] The mechanisms of Phospholipase C 1 in Colorectal Cancer Progression.2020

    • Author(s)
      Reiko Satow, Kiyoko Fukami.
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 悪性黒色腫の薬剤耐性阻害を目指したZIC5阻害薬の探索2020

    • Author(s)
      浅野亜由美、佐藤礼子、深見希代子
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Screening and Identification of Drug Candidate Compounds Targeting Drug Resistance of Melanoma2019

    • Author(s)
      渡邉尊、佐藤礼子、深見希代子
    • Organizer
      日本癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 大腸癌進展におけるPhospholipase Cδ1 のProtein Kinase Cを介した作用機序の解明2019

    • Author(s)
      太田紗瑛、鈴木悠大、久保田汐里、麻田偲, 佐藤礼子, 深見希代子
    • Organizer
      日本生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 日本生化学会奨励賞受賞講演2018

    • Author(s)
      佐藤礼子
    • Organizer
      第91回日本生化学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 日本癌学会奨励賞受賞講演2018

    • Author(s)
      佐藤礼子、深見希代子
    • Organizer
      日本癌学会奨励賞受賞講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ZIC5はPDGFDを介してFAKやSTAT3を活性化し、前立腺癌及び大腸癌の薬剤耐性を促進する2018

    • Author(s)
      稲垣翔太、加藤千明、下澤誠、佐藤礼子、深見希代子
    • Organizer
      第91回日本生化学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 大腸癌進展におけるPhospholipase C d1 の作用機序の解明2018

    • Author(s)
      久保田汐里、麻田偲, 佐藤礼子, 深見希代子
    • Organizer
      第91回日本生化学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Molecular Mechanisms of Phospholipase C Delta 1 in Colorectal Cancer Cells2018

    • Author(s)
      久保田汐里、麻田偲, 佐藤礼子, 深見希代子
    • Organizer
      第70回日本細胞生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経冠形成遺伝子群に対するスクリーニングによる薬剤耐性促進因子の同定と機能解析2017

    • Author(s)
      佐藤礼子、遠藤未来、加藤千明、稲垣翔太、深見希代子
    • Organizer
      第90回日本生化学会 (ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ZIC5はFAKやSTAT3の活性化を介してがん細胞の薬剤耐性を亢進させる2017

    • Author(s)
      佐藤礼子、深見希代子
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ZIC5はPDGFDを介してFAKとSTAT3を活性化し、がんの薬剤耐性を促進する2017

    • Author(s)
      稲垣翔太、加藤千明、遠藤未来、佐藤礼子、深見希代子
    • Organizer
      第69回日本細胞生物学会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京薬科大学生命科学部ゲノム病態医科学研究室HP

    • URL

      http://toyaku-ls-genome.com/

    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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