| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
Brain can monitor an increase or a decrease in blood glucose levels, by neurons called glucose sensing neurons. Glucose sensing neurons regulate glucose metabolisms in peripheral tissues to maintain normal glucose levels. Obesity attenuates the function of glucose sensing neurons and increases blood glucose levels. This project tried to find its molecular mechanism. We found a molecule, which can improve the function of glucose sensing neurons in obese mice. The molecule has a therapeutic effect on the diabetic hyperglycemia.
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