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Development of chromosome editing

Research Project

Project/Area Number 17H05063
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionInstitute of Physical and Chemical Research (2018-2020)
University of Tsukuba (2017)

Principal Investigator

Hayashi Yohei  国立研究開発法人理化学研究所, バイオリソース研究センター, チームリーダー (90780130)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2017: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
KeywordsiPS細胞 / 染色体異常 / 片親性ダイソミー / 染色体欠失 / 染色体 / 細胞・組織 / 再生医学 / 発現制御 / ゲノム / バイオテクノロジー
Outline of Final Research Achievements

Chromosome aberration is a highly prevalent genetic disorder, but there is currently no fundamental treatment to repair the chromosome aberration itself. In this study, we aim to propose a completely new concept of chromosome therapy as a "chromosome editing" method. In this study, we aim to propose a completely new concept of chromosome therapy, "chromosome editing".

Academic Significance and Societal Importance of the Research Achievements

染色体異常は非常に高頻度で見られる遺伝的疾患であるが、染色体異常そのものを修復する根本的な治療法は現在のところ存在しない。この研究の完成により、染色体異常を持った患者からiPS 細胞を作成し、培養状態にて染色体を修復したのちに、元の患者で機能が損なわれている臓器、細胞種を分化誘導し、移植するという再生医療が可能であることが示唆できる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (8 results)

All 2021 2020 2019

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (3 results) (of which Invited: 3 results)

  • [Journal Article] Generation of two human induced pluripotent stem cell lines derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations2021

    • Author(s)
      Kuramochi Yuji、Awaya Tomonari、Matsuo-Takasaki Mami、Takami Miho、An Yuri、Li Jingyue、Hemmi Yasuko、Wakabayashi Tamami、Arai Yutaka、Inoue Jun、Noguchi Michiya、Nakamura Yukio、Asaka Isao、Akimoto Kazunori、Saito Megumu K.、Hayashi Yohei
    • Journal Title

      Stem Cell Research

      Volume: 53 Pages: 102337-102337

    • DOI

      10.1016/j.scr.2021.102337

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of two human induced pluripotent stem cell lines derived from two juvenile nephronophthisis patients with NPHP1 deletion2020

    • Author(s)
      Arai Yutaka、Takami Miho、An Yuri、Matsuo-Takasaki Mami、Hemmi Yasuko、Wakabayashi Tamami、Inoue Jun、Noguchi Michiya、Nakamura Yukio、Sugimoto Keisuke、Takemura Tsukasa、Okita Keisuke、Osafune Kenji、Takasato Minoru、Hayata Tadayoshi、Hayashi Yohei
    • Journal Title

      Stem Cell Research

      Volume: 45 Pages: 101815-101815

    • DOI

      10.1016/j.scr.2020.101815

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem Cells2020

    • Author(s)
      Hayashi Yohei、Takami Miho、Matsuo-Takasaki Mami
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 14 Pages: 224-224

    • DOI

      10.3389/fncel.2020.00224

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP7202019

    • Author(s)
      Fukuda Aya、Honda Shiho、Fujioka Norie、Sekiguchi Yuya、Mizuno Seiya、Miwa Yoshihiro、Sugiyama Fumihiro、Hayashi Yohei、Nishimura Ken、Hisatake Koji
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 11 Pages: 0225213-0225213

    • DOI

      10.1371/journal.pone.0225213

    • NAID

      120007132627

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming2019

    • Author(s)
      Bui Phuong Linh、Nishimura Ken、Seminario Mondejar Gonzalo、Kumar Arun、Aizawa Shiho、Murano Kensaku、Nagata Kyosuke、Hayashi Yohei、Fukuda Aya、Onuma Yasuko、Ito Yuzuru、Nakanishi Mahito、Hisatake Koji
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 7 Pages: 1909-1922

    • DOI

      10.1016/j.celrep.2019.10.010

    • NAID

      120007127699

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 非公表2020

    • Author(s)
      林 洋平
    • Organizer
      日本レーザー学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 非公表2019

    • Author(s)
      林 洋平
    • Organizer
      日本腎臓学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 非公表2019

    • Author(s)
      林 洋平
    • Organizer
      日本動物実験代替法学会
    • Related Report
      2019 Annual Research Report
    • Invited

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Published: 2017-04-28   Modified: 2023-12-25  

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