Herpesvirus-mediated regulatory mechanism of cellular phosphorylation events
| Project/Area Number |
17H05069
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kato Akihisa 東京大学, 医科学研究所, 准教授 (40581187)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2019: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2018: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 単純ヘルペスウイルス / mTOR / TLR3 / MAPK / ERK / ヘルペス脳炎 / 細胞間伝播 / HSV / Us3 / 宿主細胞基質 / キノーム / ドラックプロファイリング / プロテインキナーゼ / mTORC2 / HSV脳炎 / HSV-1 / ドラッグリプロファイリング / ヘルペス性脳炎 / キノーム解析 / リン酸化 |
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| Outline of Final Research Achievements |
In this study, we investigated whether viral replication and/or virulence are regulated by herpesvirus-induced cellular phosphorylation events. We found that (i) the TLR3/mTOR axis contributed to the innate immune response against herpes simplex virus in the central nervous system of mice and (ii) the MAPK/ERK signaling pathway was involved in the cell-to-cell spread of representative members from all herpesvirus subfamilies. Collectively, these results reveal an important role of cellular phosphorylation in the life cycle of herpesviruses, thereby opening up possibilities for new therapeutic strategies against these viral pathogens.
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| Academic Significance and Societal Importance of the Research Achievements |
周知の通り、宿主キナーゼは極めて有望な創薬標的分子であることから、本研究成果は、ヘルペスウイルス感染症の克服に目掛けた重要な基礎的知見となることが期待される。また、数多くのウイルスが効率的な増殖に宿主キナーゼを利用することから、本研究で確立した研究手法や得られた知見は、他のウイルス研究にもフィードバックが可能であると考えられる。
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.2018
Author(s)
Sato R, Kato A, Chimura T, Saitoh SI, Shibata T, Murakami Y, Fukui R, Liu K, Zhang Y, Arii J, Sun-Wada GH, Wada Y, Ikenoue T, Barber GN, Manabe T, Kawaguchi Y, Miyake K.
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Journal Title
Nat Immunol.
Volume: 19
Issue: 10
Pages: 1071-1082
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.2018
Author(s)
Maruzuru Y, Ichinohe T, Sato R, Miyake K, Okano T, Suzuki T, Koshiba T, Koyanagi N, Tsuda S, Watanabe M, Arii J, Kato A, Kawaguchi Y.
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Journal Title
Cell Host Microbe.
Volume: 23
Issue: 2
Pages: 254-265
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.2017
Author(s)
Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y.
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Journal Title
J Clin Invest.
Volume: 127
Issue: 10
Pages: 3784-3795
DOI
Related Report
Peer Reviewed / Open Access
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