| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2019: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2018: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Outline of Final Research Achievements |
Natural killer (NK) cells play an essential role in controlling viral infections and cancers. NK cells are believe to be short-lived immune cells and immediately die after when they kill their target cells. However, it has been recently reported that NK cells can differentiate into long-lived memory NK cells with enhanced cytotoxicity. However, a critical factor which regulates the differentiation into memory NK cells has not been identified. In this study, we identified the critical regulator of the differentiation and the function of memory NK cells. These findings encourage us to develop vaccines for incurable viral infections and cancer immunotherapies.
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