| Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2017: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
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| Outline of Final Research Achievements |
Upon antigen-recognition, activated B cells differentiate into antibody-secreting plasma cells or germinal center (GC) B cells, precursors of memory B cells with high affinity for antigen, both of which play an important role in protective immunity against bacterial and viral infection. However, it has been unclear what factors determine B cell fate and induce plasma cell or GC B cell differentiation. In this study, we demonstrated that cellular metabolic reprogramming can determine B cell fate and revealed the underlying molecular mechanisms.
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