| Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
|
|---|
| Outline of Final Research Achievements |
This study suggested that a cellular origin of the bone marrow PDPN-expressing stromal cells discovered by the principal investigator is skeletal stem cells (SSCs). We analyzed the distribution of bone marrow PDPN-expressing stromal cells during bone and bone marrow development, especially in the secondary ossification center marrow formed at the epiphysis. We found that, during the formation of the secondary ossification center at the ends of bones, PDPN-positive cells invaded into the secondary ossification center along with periosteal vasculatures and populated the primary marrow. Furthermore, using an in vitro model, we found that PDPN-positive stromal cells maintained vascular homeostasis as a physiological function.
|
