Interactions between sensory and emotions for chronic pain
Project/Area Number |
17H05074
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
Pain science
|
Research Institution | Hyogo Medical University |
Principal Investigator |
KOGA KOHEI 兵庫医科大学, 医学部, 講師 (50768455)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2017: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
|
Keywords | 前帯状回 / 慢性疼痛 / シナプス可塑性 / 神経回路 / 痛み |
Outline of Final Research Achievements |
Chronic pain consists of sensory and emotional aspects, and both two aspects interact each other. However, the neural mechanisms and circuits on sensory-emotional interactions are still unknown. We focused on the anterior cingulate cortex (ACC), which is involved in chronic pain and anxiety, and studied the selective projections to form presynaptic long-term potentiation in the ACC. We found that the ACC receives inputs from thalamus mono-synaptically as well as poly-synaptically. Furthermore, an animal model of chronic pain attenuated GABAergic inhibitory synaptic transmission in the ACC. An electrophysilogical study showed that a chronic pain model reduced the release of GABA. When we activate muscarinic M1 receptors within the ACC, mechanical hypersensitivity was alleviated through facilitating muscarinic M1 receptors on GABAergic transmissions in the ACC.
|
Academic Significance and Societal Importance of the Research Achievements |
前帯状回皮質は、慢性疼痛と不安の形成に関わる大脳皮質の一つである。前帯状回における興奮性シナプスおよび抑制性シナプスが慢性疼痛によっていかに可塑的変化を形成するかや皮質内の局所神経回路が明らかになると、前帯状回における慢性疼痛や不安の仕組みが解明される。本研究結果は、上位中枢に作用する慢性疼痛に対する創薬開発に役立つ可能性がある。さらに、このような感覚がいかに情動や感情を形成し、相互に作用し合うかの神経分子機構が明らかとなると、様々な感覚ー情動系の解明に発展する広範囲な神経科学分野に貢献できる。
|
Report
(4 results)
Research Products
(22 results)
-
-
-
-
-
[Journal Article] Stimulating muscarinic M1 receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats2019
Author(s)
Koga K, Matsuzaki Y, Migita K, Shimoyama S, Eto F, Nakagawa T, Matsumoto T, Terada K, Mishima K, Furue H, Honda K
-
Journal Title
Brain Res
Volume: 1704
Pages: 187-195
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
[Journal Article] Propofol anesthesia is reduced in Phospholipase C-related inactive protein type-1 knockout mice2017
Author(s)
Nikaido Y, Furukawa T, Shimoyama S, Yamada J, Migita K, Koga K, Kushikata T, Hirota K, Kanematsu T, Hirata M, Ueno S
-
Journal Title
The Journal of pharmacology and experimental therapeutics
Volume: 361(3)
Issue: 3
Pages: 367-374
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Presentation] Establishment of in vivo field excitatory post synaptic potential (fEPSP) recording system at hippocampal CA3-CA3 synapses.2018
Author(s)
Oishi N, Koga K, Nomoto M, Ohkawa N, Tsujimura S, Sano Y, Saitoh Y, Nishizono H, Matsuo M, Muramatsu S, Inokuchi K
Organizer
第41回 日本神経科学大会
Related Report
-
-
-
-