Development of a hybrid tomosynthesis and acoustic imaging modality for early detection of breast cancer
| Project/Area Number |
17H05075
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Hokkaido University |
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Principal Investigator |
PENG HAO 北海道大学, 国際連携研究教育局, 招へい教員 (70790195)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
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| Keywords | Breast Imaging / breast imaging / x-ray acoustic / molecular imaging / spatial resolution / contrast recovery / Breast cancer / Tomosynthesis / Acoustic imaging / X-ray / Breast Cancer |
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| Outline of Final Research Achievements |
This proposal aims to develop a novel hybrid imaging strategy of breast tomosynthesis and x-ray acoustic breast imaging (XABI) for early detection of breast cancer. It will not only provide additional spatial information in three dimensions but also enhance contrast recovery of micro-calcifications/lesions. With the proposed platform, x-ray for tomosynthesis will stimulate simultaneously the production of acoustic signals from x-ray absorbing targets (either micro-calcification itself or injected contrast agents). We expect that it has the potential to detect small lesion while demonstrating comparable specificity to other methods currently used in breast molecular imaging. The proposal focuses on two specific aims: 1) Develop a comprehensive framework to characterize the performances of a XABI system and optimize the system design ; 2) Develop a XABI prototype to realize simultaneous mammography and x-ray induced acoustic imaging and demonstrate the feasibility using phantom studies.
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| Academic Significance and Societal Importance of the Research Achievements |
This study introduced, for the very first time, the principle and implementation of x-ray induced acoustic imaging technique for breast cancer. The novel imaging modality work synergistically with breast tomosynthesis to produce images that would otherwise be impossible to attain.
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Report
(4 results)
Research Products
(6 results)
