Development of a hybrid tomosynthesis and acoustic imaging modality for early detection of breast cancer

• Project/Area Number: 17H05075
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Hokkaido University
• Principal Investigator: PENG HAO 北海道大学, 国際連携研究教育局, 招へい教員 (70790195)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000); Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
• Keywords: Breast Imaging / breast imaging / x-ray acoustic / molecular imaging / spatial resolution / contrast recovery / Breast cancer / Tomosynthesis / Acoustic imaging / X-ray / Breast Cancer

Outline of Final Research Achievements

This proposal aims to develop a novel hybrid imaging strategy of breast tomosynthesis and x-ray acoustic breast imaging (XABI) for early detection of breast cancer. It will not only provide additional spatial information in three dimensions but also enhance contrast recovery of micro-calcifications/lesions. With the proposed platform, x-ray for tomosynthesis will stimulate simultaneously the production of acoustic signals from x-ray absorbing targets (either micro-calcification itself or injected contrast agents). We expect that it has the potential to detect small lesion while demonstrating comparable specificity to other methods currently used in breast molecular imaging. The proposal focuses on two specific aims: 1) Develop a comprehensive framework to characterize the performances of a XABI system and optimize the system design ; 2) Develop a XABI prototype to realize simultaneous mammography and x-ray induced acoustic imaging and demonstrate the feasibility using phantom studies.

Academic Significance and Societal Importance of the Research Achievements

This study introduced, for the very first time, the principle and implementation of x-ray induced acoustic imaging technique for breast cancer. The novel imaging modality work synergistically with breast tomosynthesis to produce images that would otherwise be impossible to attain.

Research Products

• [Journal Article] Simulation studies of time reversal‐based protoacoustic reconstruction for range and dose verification in proton therapy (2019)
  • Author(s): Yu Yajun、Li Zhongxing、Zhang Dong、Xing Lei、Peng Hao
  • Journal Title: Medical Physics Volume: 46(8) Issue: 8 Pages: 3649-3662
  • DOI: 10.1002/mp.13661
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Robust Beam Hardening Artifacts Reduction for Computed Tomography Using Spectrum Modeling (2019)
  • Author(s): Zhao Wei、Li Dengwang、Niu Kai、Qin Wenjian、Peng Hao、Niu Tianye
  • Journal Title: IEEE Transactions on Computational Imaging Volume: 5 Issue: 2 Pages: 333-342
  • DOI: 10.1109/tci.2018.2884479
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Modified fast adaptive scatter kernel superposition (mfASKS) correction and its dosimetric impact on CBCT‐based proton therapy dose calculation (2019)
  • Author(s): Nomura Yusuke、Xu Qiong、Peng Hao、Takao Seishin、Shimizu Shinichi、Xing Lei、Shirato Hiroki
  • Journal Title: Medical Physics Volume: 47 Issue: 1 Pages: 190-200
  • DOI: 10.1002/mp.13878
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] of X-Ray-Induced Acoustic Computed Tomography for Breast Imaging by Monte Carlo Simulation (2019)
  • Author(s): Jeffrey Wang, Yusuke Nomura, Hiroki Shirato, Lei Xing, Hao Peng
  • Organizer: Annual Meeting of the American Association of Physicists in Medicine
  • Int'l Joint Research
• [Presentation] Feasibility of X-Ray-Induced Acoustic Computed Tomography for Breast Imaging by Monte Carlo Simulation (2019)
  • Author(s): Jeffrey Wang, Yusuke Nomura, Hiroki Shirato, Lei Xing, Hao Peng
  • Organizer: Annual Meeting of the American Association of Physicists in Medicine 2019
  • Int'l Joint Research
• [Presentation] Time Reversal-Based Protoacoustic Reconstruction for Range and Dose Verification in Proton Therapy (2018)
  • Author(s): Y Yu , D Zhang , L Xing, H Peng
  • Organizer: Annual Meeting of the American Association of Physicists in Medicine 2018
  • Int'l Joint Research / Invited