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Development of a platform for clinical epidemiological and economic research using large-scale medical and nursing care related databases

Research Project

Project/Area Number 17H05077
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Epidemiology and preventive medicine
Research InstitutionThe University of Tokyo

Principal Investigator

Matsui Hiroki  東京大学, 大学院医学系研究科(医学部), 助教 (70608794)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Keywords大規模医療データベース / NDB / 介護レセプト / 深層学習 / データフュージョン / 臨床疫学 / 大規模医療介護データ / ユーザーインターフェース / 大規模データベース / 医療 / 介護 / NDBデータ / DPCデータ / 介護データ / 健診データ / 個人情報 / 疫学研究 / データサイエンス / リスクモデル / DPC / 社会医学
Outline of Final Research Achievements

The secondary use of large-scale medical data is becoming more and more important. The purpose of this study was to conduct epidemiological research by analyzing the NDB. And to analyze the NDB in conjunction with other databases.
In order to conduct research using the NDB, there was a problem that the data structure was complicated. Therefore, in this study, we defined a data structure that is easy for researchers to use, developed our own system for extracting and converting research data from NDB, and conducted epidemiological research. In addition, we developed a method for analyzing the data without linking the databases by using methods such as deep learning, which has been attracting attention in recent years. In addition, we constructed an actual database with ID-connected analysis.

Academic Significance and Societal Importance of the Research Achievements

本研究により、今まで十分に実施されてこなかったNDBの長期追跡データを用いた疫学研究の実施が可能となった。
さらに、今までは制度上の問題で実施できなかった、データベース間に患者属性が散らばる場合でのデータ解析を、データベース突合を行わずに実施する方法を考案した。加えて、実際にデータベース間を突合したデータの取得にも成功した。今後、今回の研究を基盤として、さらなる疫学研究の実施が可能となった。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (19 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 4 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Sodium‐glucose cotransporter‐2 inhibitors and the risk of urinary tract infection among diabetic patients in Japan: Target trial emulation using a nationwide administrative claims database2021

    • Author(s)
      Takeuchi Yoshinori、Kumamaru Hiraku、Hagiwara Yasuhiro、Matsui Hiroki、Yasunaga Hideo、Miyata Hiroaki、Matsuyama Yutaka
    • Journal Title

      Diabetes, Obesity and Metabolism

      Volume: 0 Issue: 6 Pages: 1-10

    • DOI

      10.1111/dom.14353

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between nutritional guidance or ophthalmological examination and discontinuation of physician visits in patients with newly diagnosed diabetes: A retrospective cohort study using a nationwide database2021

    • Author(s)
      Okada Akira、Ono Sachiko、Yamaguchi Satoko、Yamana Hayato、Ikeda Kurakawa Kayo、Michihata Nobuaki、Matsui Hiroki、Nangaku Masaomi、Yamauchi Toshimasa、Yasunaga Hideo、Kadowaki Takashi
    • Journal Title

      Journal of Diabetes Investigation

      Volume: N/A Issue: 9 Pages: 1619-1631

    • DOI

      10.1111/jdi.13510

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Volatile versus Total Intravenous Anesthesia for Cancer Prognosis in Patients Having Digestive Cancer Surgery2020

    • Author(s)
      Makito Kanako、Matsui Hiroki、Fushimi Kiyohide、Yasunaga Hideo
    • Journal Title

      Anesthesiology

      Volume: 133 Issue: 4 Pages: 764-773

    • DOI

      10.1097/aln.0000000000003440

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ophthalmic Corticosteroids in Pregnant Women with Allergic Conjunctivitis and Adverse Neonatal Outcomes: Propensity Score Analyses2020

    • Author(s)
      Hashimoto Yohei、Michihata Nobuaki、Yamana Hayato、Shigemi Daisuke、Morita Kojiro、Matsui Hiroki、Yasunaga Hideo、Aihara Makoto
    • Journal Title

      American Journal of Ophthalmology

      Volume: 220 Pages: 91-101

    • DOI

      10.1016/j.ajo.2020.07.011

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vasopressin versus epinephrine as adjunct vasopressors for septic shock2020

    • Author(s)
      Aso Shotaro、Matsui Hiroki、Fushimi Kiyohide、Yasunaga Hideo
    • Journal Title

      Intensive Care Medicine

      Volume: 46 Issue: 7 Pages: 1484-1485

    • DOI

      10.1007/s00134-020-06012-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early prediction model of organ/space surgical site infection after elective gastrointestinal or hepatopancreatobiliary cancer surgery2020

    • Author(s)
      Okui Jun、Ueno Ryo、Matsui Hiroki、Uegami Wataru、Hayashi Hiroshi、Miyajima Toru、Kusanagi Hiroshi
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: - Issue: 9 Pages: 916-922

    • DOI

      10.1016/j.jiac.2020.04.009

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Machine Learning-Based Prediction Models for 30-Day Readmission after Hospitalization for Chronic Obstructive Pulmonary Disease2019

    • Author(s)
      Goto Tadahiro、Jo Taisuke、Matsui Hiroki、Fushimi Kiyohide、Hayashi Hiroyuki、Yasunaga Hideo
    • Journal Title

      COPD: Journal of Chronic Obstructive Pulmonary Disease

      Volume: 16 Issue: 5-6 Pages: 338-343

    • DOI

      10.1080/15412555.2019.1688278

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intensive In-Hospital Rehabilitation After Hip Fracture Surgery and Activities of Daily Living in Patients With Dementia: Retrospective Analysis of a Nationwide Inpatient Database2019

    • Author(s)
      Uda Kazuaki、Matsui Hiroki、Fushimi Kiyohide、Yasunaga Hideo
    • Journal Title

      Archives of Physical Medicine and Rehabilitation

      Volume: 100 Issue: 12 Pages: 2301-2307

    • DOI

      10.1016/j.apmr.2019.06.019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors associated with long-term prescription of benzodiazepine: a retrospective cohort study using a health insurance database in Japan2019

    • Author(s)
      Takano Ayumi、Ono Sachiko、Yamana Hayato、Matsui Hiroki、Matsumoto Toshihiko、Yasunaga Hideo、Kawakami Norito
    • Journal Title

      BMJ Open

      Volume: 9 Issue: 7 Pages: e029641-e029641

    • DOI

      10.1136/bmjopen-2019-029641

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antibiotic prescription among outpatients in a prefecture of Japan, 2012?2013: a retrospective claims database study2019

    • Author(s)
      Hashimoto Hideki、Matsui Hiroki、Sasabuchi Yusuke、Yasunaga Hideo、Kotani Kazuhiko、Nagai Ryozo、Hatakeyama Shuji
    • Journal Title

      BMJ Open

      Volume: 9 Issue: 4 Pages: e026251-e026251

    • DOI

      10.1136/bmjopen-2018-026251

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of neurologic specialist staffing on 30-day in-hospital mortality after cerebral infarction2019

    • Author(s)
      Hiroki Matsui , Soichi Koike , Kiyohide Fushimi , Tomoki Wada , Hideo Yasunaga
    • Journal Title

      Annals of Clinical Epidemiology

      Volume: 1 Pages: 86-94

    • NAID

      130007844288

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcomes after early and delayed rehabilitation for exacerbation of chronic obstructive pulmonary disease: a nationwide retrospective cohort study in Japan2017

    • Author(s)
      Matsui Hiroki、Jo Taisuke、Fushimi Kiyohide、Yasunaga Hideo
    • Journal Title

      Respiratory Research

      Volume: 18 Issue: 1

    • DOI

      10.1186/s12931-017-0552-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 深層学習をレセプト記載情報に適用した入院予後予測モデルの構築と妥当性検証2019

    • Author(s)
      松居 宏樹
    • Organizer
      日本臨床疫学会第3回年次学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肺炎症例におけるレセプト記載を基にした深層学習リスクモデルの構築と妥当性検証2019

    • Author(s)
      松居宏樹, 伏見清秀, 康永秀生
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺炎症例における深層学習をレセプト記載情報に適用した予後予測モデルの構築と妥当性検証2018

    • Author(s)
      松居宏樹, 伏見清秀, 康永秀生
    • Organizer
      日本臨床疫学会第2回年次学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] レセプト情報等オンサイトリサーチセンターの現況および今後について- これまでの進捗の報告、および今後の第三者利用について -2017

    • Author(s)
      松居宏樹、佐藤大介、大江和彦
    • Organizer
      第37回医療情報学連合大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] レセプトデータベースを用いた心不全症例における入院中リハビリテーションの効果の検証2017

    • Author(s)
      松居宏樹、康永秀生
    • Organizer
      日本臨床疫学会 第1回年次学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 臨床データにおける多重代入法を用いたデータ・フュージョンの使用例2017

    • Author(s)
      松居宏樹、康永秀生、伏見清秀
    • Organizer
      第76回日本公衆衛生学会総会
    • Related Report
      2017 Annual Research Report
  • [Remarks] Research map

    • URL

      https://researchmap.jp/ptmatsui

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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