| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2017: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Outline of Final Research Achievements |
We performed gene expression analysis of gastric stem cells, progenitors, and other mature cell types, and identified novel markers specific for each cell population. We generated several mouse lines that mark these specific cell types. We analyzed histological and molecular changes in stem and other cell types during early carcinogenesis, and identified the mechanism of the development of gastric metaplasia and cancer. We also showed that tuft cell-mediated acetylcholine signal is important for stem cell function and mucosal regeneration via ERK pathway, and identified several chemicals that revert the gastric precancerous change, loss of parietal cells.
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