Development of new immunotherapy treatments toward a cure for HIV
| Project/Area Number |
17H05087
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
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Principal Investigator |
Yamamoto Takuya 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 免疫老化プロジェクト, プロジェクトリーダー (60752368)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2018: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | エイズ / 潜伏感染 / 免疫療法 / アジュバント / HIV / SIV / CTL / 自然免疫 |
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| Outline of Final Research Achievements |
Elimination of the hidden HIV-1 is required for the cure from diseases related to HIV-1 infection. The latently infected cells under cART located mainly in lymph tissues. For the eradication of such cells, an appropriate animal model, which recapitulate pathological features after HIV-1 infection is essentially required. Here, we have established the macaque model under cART during chronic phase of infection, which potentially reflects many clinical features of HIV-1 infected individuals under cART. On the other hand, we found the potential usages of STING ligands for HIV treatment because STING ligands could stimulate latently infected cells and also activate immune responses simultaneously at least in vitro. Thus, we injected either a STING ligand or saline in two cART treated monkeys. However, we couldn't see any significant difference between them, therefore we are going to increase the number of monkeys for further investigation.
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| Academic Significance and Societal Importance of the Research Achievements |
HIV-1に対する抗ウイルス薬は広く普及しているが、依然としてHIV-1感染症に対する根治療法の開発は世界的にも望まれており、本研究を含む新規治療法の開発研究の学術的、社会的意義は高いと考えられる。その目的達成のため、これまでサルを用いた急性期治療モデルは世界的にも多数報告されていたが、本研究により実臨床に近い慢性期治療モデルを世界に先駆けて樹立できたことは、エイズ根治に向けた大きな一歩を踏み出せたと考えられる。さらに、新規免疫療法となる可能性をもつ免疫賦活化剤としてのSTINGリガンドを同定することができたことで、本研究成果が、今後より具体的な新規治療法の確立へと繋がることが期待される。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread2019
Author(s)
Hataye Jason M.、Casazza Joseph P.、Best Katharine、Liang C. Jason、Immonen Taina T.、Ambrozak David R.、Darko Samuel、Henry Amy R.、Laboune Farida、Maldarelli Frank、Douek Daniel C.、Hengartner Nicolas W.、Yamamoto Takuya、Keele Brandon F.、Perelson Alan S.、Koup Richard A.
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Journal Title
Cell Host & Microbe
Volume: 26
Issue: 6
Pages: 748-763.e20
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Elderly human hematopoietic progenitor cells express cellular senescence markers and are more susceptible to pyroptosis2018
Author(s)
Fali T, Fabre-Mersseman V, Yamamoto T, Bayard C, Papagno L, Fastenackels S, Zoorab R, Koup RA, Boddaert J, Sauce D, Appay V.
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Journal Title
JCI Insight
Volume: 3
Issue: 13
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access
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