| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2019: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2017: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Outline of Final Research Achievements |
Streptococcus pneumoniae is a pathogen that poses one of the greatest threats to human health, including pneumonia, sepsis, and meningitis. In this study, we focused on evolutionarily selective pressures on pneumococcal proteins localized on the bacterial cell surface.
Our results indicate that evolutinarily conserved cell surface proteins function as a virulence factor in pneumococcal infection. Furthermore, molecular evolutional analysis was shown to be a powerful system that reflects the importance of virulence factors in human clinical conditions, since calculations are performed based on bacterial genome diversity following transmission of infection in an uncontrolled population.
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