| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Outline of Final Research Achievements |
The purpose of this study was to elucidate the role of crosstalk between osteocytes and sensory nerves via gap junctions in the pathogenesis of bone pain associated with bone metastatic tumor and in bone dysbolism disease. In addition, we have developed clinical applications for bone pain relief and therapeutic agents for bone lesions. The results of this study revealed that osteocytes develop intimate physical contact with sensory neurons in bone, and transfer small molecules via Cx43 to excite sensory neurons and evoke bone pain, indicating a novel pain-modulating function of osteocytes. The communication between osteocytes and sensory neurons may provide a new potential target for treating bone pain.
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