Elucidation of the pathogenesis of bone diseases mediated by osteocyte-sensory nerve networks

• Project/Area Number: 17H05104
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: The University of Tokushima
• Principal Investigator: HIASA Masahiro 徳島大学, 大学院医歯薬学研究部(歯学域), 講師 (90511337)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000); Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2017: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
• Keywords: がん / 骨細胞 / 感覚神経 / 痛み / 骨痛 / がんと骨病変 / 神経 / Cx43 / 癌

Outline of Final Research Achievements

The purpose of this study was to elucidate the role of crosstalk between osteocytes and sensory nerves via gap junctions in the pathogenesis of bone pain associated with bone metastatic tumor and in bone dysbolism disease. In addition, we have developed clinical applications for bone pain relief and therapeutic agents for bone lesions. The results of this study revealed that osteocytes develop intimate physical contact with sensory neurons in bone, and transfer small molecules via Cx43 to excite sensory neurons and evoke bone pain, indicating a novel pain-modulating function of osteocytes. The communication between osteocytes and sensory neurons may provide a new potential target for treating bone pain.

Academic Significance and Societal Importance of the Research Achievements

骨痛は既存の鎮痛薬が効かず苦慮する事例をしばしば認め確立された鎮痛法も乏しい。そのため、より良い治療には骨痛で起こる感覚神経の病的興奮の分子メカニズムを解明することが必要であるが未だ不明な点が多い。本研究は骨組織で大多数を占めメカノセンサーとして働く骨細胞が、骨内を走行する感覚神経とCx43ギャップ結合を介したネットワークを構築し、互いに機能制御を行うことを明らかとした。また、骨細胞をターゲットとした鎮痛法が臨床応用できる可能性を示した。

Research Products

• [Int'l Joint Research] Indiana University School of Medicine(米国)
• [Int'l Joint Research] Indiana University School of Medicine(米国)
• [Journal Article] The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone (2021)
  • Author(s): Okui Tatsuo、Hiasa Masahiro、Ryumon Shoji、Ono Kisho、Kunisada Yuki、Ibaragi Soichiro、Sasaki Akira、Roodman G. David、White Fletcher A.、Yoneda Toshiyuki
  • Journal Title: Journal of Bone Oncology Volume: 26 Pages: 100330-100330
  • DOI: 10.1016/j.jbo.2020.100330
  • NAID: 120007032763
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma. (2021)
  • Author(s): Keiichiro Watanabe、Ariunzaya Bat-Erdene、Hirofumi Tenshin、Qu Cui、Jumpei Teramachi、Masahiro Hiasa、Asuka Oda、Takeshi Harada、Hirokazu Miki、Kimiko Sogabe、Masahiro Oura、Ryohei Sumitani、Yukari Mitsui、Itsuro Endo、Eiji Tanaka、Makoto Kawatani、Hiroyuki Osada、Toshio Matsumoto、Masahiro Abe
  • Journal Title: Haematologica Volume: 106 Pages: 1172-1177
  • DOI: 10.3324/haematol.2019.244418
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat. (2020)
  • Author(s): 1. Ashtar M, Tenshin H, Teramachi J, Bat-Erdene A, Hiasa M, Oda A, Tanimoto K, Shimizu S, Higa Y, Harada T, Oura M, Sogabe K, Nakamura S, Fujii S, Sumitani R, Miki H, Udaka K, Takahashi M, Kagawa K, Endo I, Tanaka E, Matsumoto T, Abe M.
  • Journal Title: Cancers Volume: 12 Pages: 929-929
  • DOI: 10.3390/cancers12040929
  • NAID: 120006894611
  • Peer Reviewed / Open Access
• [Journal Article] TAK1 is a pivotal therapeutic target for tumor progression and bone destruction in myeloma. (2020)
  • Author(s): 2. Teramachi J, Tenshin H, Hiasa M, Oda A, Bat-Erdene A, Harada T, Nakamura S, Ashtar M, Shimizu S, Iwasa M, Sogabe K, Oura M, Fujii S, Kagawa K, Miki H, Endo I, Haneji T, Matsumoto T, Abe M.
  • Journal Title: Haematologica Volume: haematol.2019
  • DOI: 10.3324/haematol.2019.234476
  • NAID: 120007180361
  • Peer Reviewed / Open Access
• [Journal Article] がん酸性環境と骨痛 (2019)
  • Author(s): 日浅雅博
  • Journal Title: BIO Clinica Volume: 34 Pages: 854-859
• [Journal Article] Class 1 HDAC and HDAC6 inhibition inversely regulates CD38 induction in myeloma cells via interferon-α and ATRA (2019)
  • Author(s): Bat-Erdene Ariunzaya、Nakamura Shingen、Oda Asuka、Iwasa Masami、Teramachi Jumpei、Ashtar Mohannad、Harada Takeshi、Miki Hirokazu、Tenshin Hirofumi、Hiasa Masahiro、Fujii Shiro、Sogabe Kimiko、Oura Masahiro、Udaka Kengo、Kagawa Kumiko、Yoshida Sumiko、Aihara Ken-ichi、Kurahashi Kiyoe、Endo Itsuro、Abe Masahiro
  • Journal Title: Br J Haematol. Volume: 印刷中 Pages: 969-974
  • DOI: 10.1111/bjh.15673
  • NAID: 120006844039
  • Peer Reviewed / Open Access
• [Journal Article] Persistent activation of calcium-sensing receptor suppresses bone turnover, increases microcracks and decreases bone strength (2019)
  • Author(s): Bingzi Dong, Itsuro Endo, Yukiyo Ohnishi, Yukari Mitsui, Kiyoe Kurahashi, Mai Kanai, Masahiro Hiasa, Jumpei Teramachi, Hirofumi Tenshin, Seiji Fukumoto, Masahiro Abe, Toshio Matsumoto.
  • Journal Title: JBMR Plus Volume: inpress
  • DOI: 10.1002/jbm4.10182
  • Peer Reviewed / Open Access
• [Journal Article] Bone and calcium metabolism associated with malignancy. Mechanism of cancer-induced bone pain. (2018)
  • Author(s): Masahiro Hiasa
  • Journal Title: Clinical Calcium Volume: 28 Pages: 1495-1502
  • Peer Reviewed
• [Journal Article] Crosstalk between sensory nerves and cancer in bone. (2018)
  • Author(s): Yoneda T, Hiasa M, Okui T.
  • Journal Title: Current Osteoporosis Reports Volume: 16(6) Pages: 648-656
  • DOI: 10.1007/s11914-018-0489-x
  • Peer Reviewed
• [Journal Article] Effect of pulsed ultrasound toothbrush on Streptococcus mutans biofilm removal (2018)
  • Author(s): Shinya Horiuchi、Hiromichi Yumoto、Tomoko Kimura、Minami Sato、Silvia Naomi Mitsui、Masahiro Hiasa、Eiji Nishikawa、El-Bialy Tarek、Eiji Tanaka
  • Journal Title: American journal of dentistry Volume: 31 Pages: 67-70
  • Peer Reviewed
• [Journal Article] Effective impairment of myeloma cells and their progenitors by hyperthermia. (2018)
  • Author(s): Hirokazu Miki, Shingen Nakamura, Asuka Oda, Hirofumi Tenshin, Jumpei Teramachi, M. Hiasa, A. Bat-Erdene, Y. Maeda, M. Oura, M. Takahashi, M. Iwasa, T. Harada, S. Fujii, K. Kurahashi, S. Yoshida, K. Kagawa, I. Endo, K. Aihara, M. Ikuo, K. Itoh, Koichiro Hayashi, Michihiro Nakamura, Masahiro Abe
  • Journal Title: Oncotarget. Volume: 9 Pages: 10307-10316
  • DOI: 10.18632/oncotarget.23121
  • NAID: 120006576960
  • Peer Reviewed
• [Journal Article] Unique anti-myeloma activity by thiazolidine-2,4-dione compounds with Pim inhibiting activity. (2018)
  • Author(s): Fujii S, Nakamura S, Oda A, Miki H, Tenshin H, Teramachi J, Hiasa M, Bat-Erdene A, Maeda Y, Oura M, Takahashi M, Iwasa M, Endo I, Yoshida S, Aihara KI, Kurahashi K, Harada T, Kagawa K, Nakao M, Sano S, Abe M.
  • Journal Title: Br J Haematol. Volume: 180(2) Pages: 246-258
  • DOI: 10.1111/bjh.15033
  • Peer Reviewed
• [Journal Article] TAK1 inhibition subverts the osteoclastogenic action of TRAIL while potentiating its antimyeloma effects (2017)
  • Author(s): Tenshin Hirofumi、Teramachi Jumpei、Tanaka Eiji、Matsumoto Toshio、Abe Masahiro (他16人中2番目）
  • Journal Title: Blood Adv. Volume: 1 Pages: 2124-2137
  • DOI: 10.1182/bloodadvances.2017008813
  • Peer Reviewed / Open Access
• [Journal Article] Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging (2017)
  • Author(s): Davis HM, Pacheco-Costa R, Atkinson EG, Brun LR, Gortazar AR, Harris J, Hiasa M, Bolarinwa SA, Yoneda T, Ivan M, Bruzzaniti A, Bellido T, Plotkin LI.
  • Journal Title: Aging Cell. Volume: 16(3) Pages: 551-563
  • DOI: 10.1111/acel.12586
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Evaluation of the effects of age on root resorption caused by orthodontic treatment. (2020)
  • Author(s): Takahashi F, Hiasa M, Horiuchi S, Honda E, Tanaka E.
  • Organizer: 9th IOC
  • Int'l Joint Research
• [Presentation] Immobilization accelerates bone loss and myeloma tumor expansion. (2020)
  • Author(s): Tanimoto K, Hiasa M, Tenshin H, Abe M, Tanaka E.
  • Organizer: 9th IOC
  • Int'l Joint Research
• [Presentation] 徳島大学病院矯正歯科における口唇裂口蓋裂患者の診療動向調査． (2020)
  • Author(s): 中上絵美、天真寛文、森 浩喜、渡邉佳一郎、日浅雅博、堀内信也、岩本 勉、橋本一郎、田中栄二
  • Organizer: 第44回日本口蓋裂学会総会・学術集会
• [Presentation] ソトス症候群に貴院する交叉咬合を伴う骨格性下顎前突 (2020)
  • Author(s): 吉永薫、塩屋園玲子、伊藤彩実、松木佑太、谷本幸多朗、渡邉佳一郎、日浅雅博、田中栄二
  • Organizer: 第63回中・四国矯正歯科学会大会
• [Presentation] 抗腫瘍薬が誘導するROSは破骨細胞分化を促進する：Xanthine oxidase阻害剤febuxostatの治療効果 (2020)
  • Author(s): 天真寛文、Mohannad Ashtar、寺町順平、日浅雅博、谷本幸多朗、清水宗、比嘉佳基、 原田武志、大浦雅博、曽我部公子、中村信元、三木浩和、遠藤逸朗、田中栄二、松本俊夫、安倍正博
  • Organizer: 第38回日本骨代謝学会学術集会
• [Presentation] 不動は骨吸収と骨髄腫進展を促進させる (2020)
  • Author(s): 谷本幸多朗、日浅雅博、天真寛文、Mohannad Ashter、清水宗、比嘉佳基、寺町順平、原田武志、中村信元、三木浩和、遠藤逸朗、田中栄二
  • Organizer: 第38回日本骨代謝学会学術集会
• [Presentation] 骨髄腫細胞のPP2A阻害因子CIP2A発現誘導を介するTAK1活性化増強機構 (2020)
  • Author(s): 清水宗、寺町順平、原田武志、小田明日香、天真寛文、日浅雅博、谷本幸多朗、比嘉佳基、田中栄二、松本俊夫、安倍正博
  • Organizer: 第38回日本骨代謝学会学術集会
• [Presentation] TAK1 upregulates the PP2A inhibitor CIP2A to potentiate survival signaling pathways in myeloma cells. (2020)
  • Author(s): 清水宗、寺町順平、原田武志、天真寛文、小田明日香、日浅雅博、遠藤逸朗、松本俊夫、田中栄二、安倍正博
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] Critical roles of TACE-TIMP-3 system in skewed osteoclast vs. dendritic cell differentiation in MM (2020)
  • Author(s): 日浅雅博、谷本幸多朗、比嘉佳基、天真寛文、曾我部公子、大浦雅博、原田武志、中村信元、三木浩和、遠藤逸朗、松本俊夫、安倍正博
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] Versatile anti-myeloma effects by elotuzumab: impact on gamma delta T cells and osteoclasts (2020)
  • Author(s): T Harada, Y Inoue, H Tenshin, A Oda, M Oura, K Sogabe, R Sumitani, S Fujii, S Nakamura, H Miki, K Kagawa, M Hiasa, J Teramachi, M Abe
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] Resumption of myeloma cell sensitivity to proteasome inhibitors by PIM and Akt inhibition (2020)
  • Author(s): 曽我部公子、原田武志、中村信元、三木浩和、小田明日香、井上雄介、住谷龍平、丸橋朋子、大浦雅博、藤井志朗、賀川久美子、天眞寛文、日浅雅博、寺町順平、安倍正博
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] Mechanical unloading aggravates bone destruction and tumor expansion in myeloma (2020)
  • Author(s): K Tanimoto，M Hiasa，H Tenshin， A Mohannad，Y Higa，S Shimizu，A Oda， T Harada，K Sogabe，M Oura，I Endo，T Matsumoto，M Abe
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] 口唇口蓋裂治療における医科歯科連携を考える (2020)
  • Author(s): 日浅雅博
  • Organizer: 第44回日本口蓋裂学会総会・学術集会
• [Presentation] 本院における口唇口蓋裂児への治療の取り組み (2020)
  • Author(s): 森 浩喜, 岩本 勉, 齋藤 早紀, 上田(山口) 公子, 高石 和美, 山村 佳子, 日浅 雅博, 堀内 信也, 田中 栄二
  • Organizer: 徳島県歯科医学大会
• [Presentation] Novel therapeutic rationale for targeting HDAC1 and PIM2 in multiple myeloma (2019)
  • Author(s): Takeshi Harada, Asuka Oda, Hiroto Ohguchi, Yohann Grondin, Hirofumi Tenshin, Masahiro Hiasa, Jumpei Teramachi, Masahiro Oura, Kimiko Sogabe, Shiroh Fujii, Shingen Nakamura, Hirokazu Miki, Hirokazu Miki, Kumiko Kagawa, Shuji Ozaki, Teru Hideshima, Kenneth C. Anderson and Masahiro Abe
  • Organizer: 61th ASH Annual Meeting & Exposition
• [Presentation] The role of NLRP3 inflammasome activation in joint inflammation and destruction in rheumatoid arthritis: novel therapeutic approaches with TAK1 inhibition (2019)
  • Author(s): Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Ashtar Mohannad, Kotaro Tanimoto, Soh Shimizu, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe
  • Organizer: 29th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting
• [Presentation] A progressive auto-amplification loop in TAK1 expression and activation in MM cells (2019)
  • Author(s): Jumpei Teramachi, Shimizu So, Hirofumi Tenshin, Bat-Erdene Ariunzaya, Masahiro Hiasa, Oda Asuka, Takeshi Harada, Ashter Mohannad, Kotaro Tanimoto, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe
  • Organizer: American Society for Bone and Mineral Society Annual meeting 2019
• [Presentation] Establishment of model mice of FGF23-related hypophosphatemia induced by iron solution administration (2019)
  • Author(s): Mai Kanai, Itsuro Endo, Yasuko Takahashi, Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Seiji Fukumoto, Masahiro Abe and Toshio Matsumoto
  • Organizer: American Society for Bone and Mineral Society Annual meeting 2019
• [Presentation] TAK1 inhibition effectively alleviates joint inflammation as well as bone destruction in rheumatoid arthritis: Suppression of NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption (2019)
  • Author(s): Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Ashtar Mohannad, Kotaro Tanimoto, Masami Iwasa, Bat-Erdene Ariunzaya, Takeshi Harada, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe
  • Organizer: American Society for Bone and Mineral Society Annual meeting 2019
• [Presentation] Effective suppression of inflammasome-mediated joints destruction by TAK1 inhibition (2019)
  • Author(s): Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Masahiro Abe and Eiji Tanaka
  • Organizer: 97th International Association for Dental Research General Session & Exhibition
• [Presentation] 歯科矯正学的に骨性癒着歯と診断された歯の歯科用CBCT画像を用いた鑑別診断 (2019)
  • Author(s): 髙橋 史子, 日浅 雅博, 堀内 信也, 誉田 栄一, 田中 栄二
  • Organizer: 第78回日本矯正歯科学会学術大会
• [Presentation] TAK1阻害は関節リウマチにおけるNLRP3インフラマソーム誘導性の炎症および骨破壊を抑制する (2019)
  • Author(s): 天眞 寛文, 寺町 順平, 日浅 雅博, 谷本 幸多朗, ASHTAR MOHANNAD, Ariunzaya Bat-Erdene, 岩佐 昌美, 原田 武志, 中村 信元, 三木 浩和, 遠藤 逸朗, 田中 栄二, 松本 俊夫, 安倍 正博
  • Organizer: 第37回日本骨代謝学会学術集会
• [Presentation] NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption in rheumatoid arthritis : the therapeutic roles of TAK1 inhibition (2019)
  • Author(s): Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, 小田 明日香, Kotaro Tanimoto, Soh Shimizu, Ashtar Mohannad, Takeshi Harada, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe
  • Organizer: 16th Meeting of Bone Biology Forum
• [Presentation] シルエットを用いた側貌に対する審美的評価 (2019)
  • Author(s): 沢田 正樹, 岩浅 亮彦, 吉村 宗之, 市原 亜起, ミツイ アカギ シルビア ナオミ, 塩屋園 玲子, 日浅 雅博, 泰江 章博, 田中 栄二
  • Organizer: 第62回中・四国矯正歯科学会大会
• [Presentation] 徳島大学病院矯正歯科における口唇裂・口蓋裂患者の合併先天異常に関する実態調査 (2019)
  • Author(s): 清水 宗, 堀内 信也, 天眞 寛文, 岩浅 亮彦, 渡邉 佳一郎, 日浅 雅博, 岩本 勉, 田中 栄二
  • Organizer: 日本口蓋裂学会
• [Presentation] TAK1阻害は骨髄腫細胞と骨髄相互作用を抑制し、腫瘍進展と骨病変形成を抑制する (2018)
  • Author(s): 寺町順平、 天真寛文、日浅雅博、遠藤逸朗、松本俊夫、安倍正博
  • Organizer: 第36回骨代謝学会学術集会
• [Presentation] TAK1阻害はTRAILによる破骨細胞活性化作用を遮断させると同時にTRAILの抗骨髄腫作用を増強する (2018)
  • Author(s): 天真寛文、寺町順平、日浅雅博、谷本幸多郎、Mohannad Ashtar、Ariunzaya Baterdene、岩佐昌美、原田武志、中村信元、三木浩和、遠藤逸朗、田中栄二、松本俊夫、安倍正博
  • Organizer: 第36回骨代謝学会学術集会
• [Presentation] カルシウム感知受容体活性型変異マウスにおける骨強度の低下 (2018)
  • Author(s): 遠藤逸朗、大西幸代、倉橋清衛、寺町順平、日浅雅博、天真寛文、福本誠二、安倍正博、松本俊夫
  • Organizer: 第36回骨代謝学会学術集会
• [Presentation] カテプシンK阻害による多発性骨髄腫骨病変部の骨量回復プロセスにおける骨細胞の 役割 (2018)
  • Author(s): 天真寛文、寺町順平、日浅雅博、谷本幸多郎、Mohannad Ashtar、Ariunzaya Baterdene、岩佐昌美、原田武志、中村信元、三木浩和、遠藤逸朗、田中栄二、松本俊夫、安倍正博
  • Organizer: 第36回骨代謝学会学術集会
• [Presentation] Impact of denervation-induced paralysis and mechanical unloading on tumor expansion in myeloma (2018)
  • Author(s): 谷本幸多朗、日浅雅博、天真寛文、寺町順平、Mohannad Ashter、Ariunzaya Baterdene、岩佐昌美、原田武志、中村信元、三木浩和、遠藤逸朗、田中栄二、松本俊夫、安倍正博
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Roles of ROS in induction of bone disease and cancer treatment-induced bone loss in myeloma (2018)
  • Author(s): Mohannad Ashtar、天真寛文、寺町順平、日浅雅博、小田明日香、谷本幸多朗、Ariunzaya BatErdene、岩佐昌美、曾我部公子、大浦雅弘、藤井志朗、賀川久美子、原田武志、中村信元、三木浩和、遠藤逸朗、田中栄二、松本俊夫、安倍正博
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Inverse regulation of c-FLIP-mediated survival in myeloma cells and osteoclasts by TRAIL (2018)
  • Author(s): 天真寛文、寺町順平、日浅雅博、小田明日香、谷本幸多朗、Mohannad Ashtar、Ariunzaya BatErdene、岩佐昌美、曾我部公子、大浦雅弘、藤井志朗、賀川久美子、原田武志、中村信元、三木浩和、遠藤逸朗、田中栄二、松本俊夫、安倍正博
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] IFN-gamma and ATRA cooperatively upregulates CD38 in myeloma cells: critical contribution of IRF1 and HDAC6. (2018)
  • Author(s): Ariunzaya Bat-Erdene, Takeshi Harada, Masami Iwasa, Asuka Oda, Shiro Fujii, Kimiko Sogabe, Shingen Nakamura, Jumpei Teramachi, Masahiro Hiasa, Hirofumi Tenshin, Mohannad Ashtar, Koutarou Tanimoto, Hirokazu Miki, Mamiko Takahashi, Masahiro Oura, Kumiko Kagawa, Masahiro Abe
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Bone anabolic effects of cathepsin K inhibition in myeloma; a role of osteocytes (2018)
  • Author(s): 日浅雅博、寺町順平、天真寛文、谷本幸多郎、Mohannad Ashtar、Ariunzaya Baterdene、岩佐昌美、原田武志、中村信元、三木浩和、遠藤逸朗、田中栄二、松本俊夫、安倍正博
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Opposite effects of TRAIL on the Sp1-c-FLIP survival pathway in myeloma cells and osteoclasts. (2018)
  • Author(s): Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Mohannad Ashtar, Kotaro Tanimoto, Iwasa Masami, Ariunzaya Bat-Erdene, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe
  • Organizer: ASBMR 2018 Annual meeting
• [Presentation] Disruption of a progressive vicious cycle between myeloma tumor growth and bone destruction by TAK1 inhibition (2018)
  • Author(s): Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Asuka Oda, Ariunzaya Bat-Erdene, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Toshio Matsumoto and Masahiro Abe
  • Organizer: ASBMR 2018 Annual meeting
• [Presentation] Bone pain-modifying actions of osteocytes via Connexin43-mediated communications with sensory nerves. (2017)
  • Author(s): Hiasa M, Okui T, Delgado-Calle J, Bellido T, Roodman GD, Plotkin L, White FA and Yoneda T
  • Organizer: 44th European Calcified Tissue Society Congress
  • Int'l Joint Research
• [Presentation] Bone anabolic effects of cathepsin K inhibition in myeloma: a role of osteocytes (2017)
  • Author(s): 日浅雅博、寺町順平、小田明日香、天真寛文、天知良太、渡邉 佳一郎、原田武志、大浦雅博、前田悠作、岩佐 昌美、藤井志朗、賀川 久美子、中村 信元、三木 浩和、遠藤 逸朗、田中 栄二、浜田賢一、松本 俊夫、安倍 正博
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] V-ATPaseプロトンポンプおよび酸感受性イオンチャンネルASIC3阻害は多発性骨髄腫の骨痛を緩和する (2017)
  • Author(s): 日浅雅博、奥井達雄、米田俊之
  • Organizer: 第35回日本骨代謝学会学術集会
• [Book] Encyclopedia of Bone Biology (2020)
  • Author(s): Toshiyuki Yoneda, Masahiro Hiasa, TatsuoOkui
  • Total Pages: 2374
  • Publisher: Elsevier Inc.
  • ISBN: 9780128140826