Budget Amount *help |
¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2017: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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Outline of Final Research Achievements |
Runx2 is an essential transcription factor for both osteoblast specification and chondrocyte hypertrophy. In this study, we performed integrative analysis of Runx2-DNA binding profile and cell-type distinct epigenetic landscape profile in mouse neonatal osteoblasts and chondrocytes. We identified cell-type specific putative enhancers targeted by Runx2 in osteoblasts and chondrocytes, and confirmed a biological function of these. Through this study, we identified a Runx2-mediated gene regulatory program in skeletal development.
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