Budget Amount *help |
¥555,490,000 (Direct Cost: ¥427,300,000、Indirect Cost: ¥128,190,000)
Fiscal Year 2021: ¥99,060,000 (Direct Cost: ¥76,200,000、Indirect Cost: ¥22,860,000)
Fiscal Year 2020: ¥88,790,000 (Direct Cost: ¥68,300,000、Indirect Cost: ¥20,490,000)
Fiscal Year 2019: ¥84,240,000 (Direct Cost: ¥64,800,000、Indirect Cost: ¥19,440,000)
Fiscal Year 2018: ¥117,000,000 (Direct Cost: ¥90,000,000、Indirect Cost: ¥27,000,000)
Fiscal Year 2017: ¥166,400,000 (Direct Cost: ¥128,000,000、Indirect Cost: ¥38,400,000)
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Outline of Final Research Achievements |
Nickel-catalyzed C-H bond activation reactions developed to date have required the use of bidentate directing groups. However, based on the elucidation of the reaction mechanism, including DFT calculations, it was found that the reaction proceeds even with a simple amide directing group when a strong base is used. Based on this finding, we have found that this strategy is applicable to the activation of various unreactive bonds, such as C-F bond, C-O bond, C-S bond, and C-CN bonds. Furthermore, C-H bond activation reactions using acylimidazole as a directing group and iridium complexes as catalysts were found. We also succeeded in developing transition metal-free C-H borylation of aromatic aldehydes using an imine as a transient directing group. We also succeeded in developing catalytic reactions involving both C-H and C-C bonds.
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