Elucidation of sleep/wakefulness regulation using forward genetic approach

• Project/Area Number: 17H06095
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: University of Tsukuba
• Principal Investigator: Yanagisawa Masashi 筑波大学, 国際統合睡眠医科学研究機構, 教授 (20202369)
• Co-Investigator(Kenkyū-buntansha): 船戸 弘正 筑波大学, 国際統合睡眠医科学研究機構, 客員教授 (90363118) ; Liu Qinghua 筑波大学, 国際統合睡眠医科学研究機構, 教授 (90723792)
• Project Period (FY): 2017-04-25 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥549,900,000 (Direct Cost: ¥423,000,000、Indirect Cost: ¥126,900,000); Fiscal Year 2021: ¥76,440,000 (Direct Cost: ¥58,800,000、Indirect Cost: ¥17,640,000); Fiscal Year 2020: ¥80,860,000 (Direct Cost: ¥62,200,000、Indirect Cost: ¥18,660,000); Fiscal Year 2019: ¥91,000,000 (Direct Cost: ¥70,000,000、Indirect Cost: ¥21,000,000); Fiscal Year 2018: ¥152,100,000 (Direct Cost: ¥117,000,000、Indirect Cost: ¥35,100,000); Fiscal Year 2017: ¥149,500,000 (Direct Cost: ¥115,000,000、Indirect Cost: ¥34,500,000)
• Keywords: 睡眠 / マウス遺伝学 / 細胞内シグナル伝達 / リン酸化 / 神経生理学 / 睡眠覚醒 / 脳神経 / 遺伝子改変マウス / ゲノム編集 / 細胞内シグナル伝達系 / 細胞内シグナル / リン酸化酵素 / 睡眠・覚醒 / ゲノムエディティング

Outline of Final Research Achievements

Forward genetic approach for sleep have led to the identification of multiple novel sleep-regulating genes. In neurons, we found that SIK3 functions as an intracellular signaling pathway for sleep need regulation. We revealed that the SIK3 signaling regulates NREM sleep amount and EEG delta range power during NREM sleep throught different brain regions. We also identified 80 phosphoproteins, SNIPPs, as molecular entities of sleepiness. These diverse and related results have greatly expanded our understanding of sleep-wake regulation.

Academic Significance and Societal Importance of the Research Achievements

我が国は世界的にも睡眠時間が少ない「睡眠負債国」として知られており、睡眠不足による社会的経済的損失は大きい。しかし、なぜ眠らなければならないのか、眠気の実体とは何かといったこと基本的なことさえ明らかではなかった。
本研究の成果により、眠りの長さや深さを制御するニューロン内の重要分子群が明らかとなった。また眠気が特定蛋白質のリン酸化修飾によって表現されていることが明らかとなった。これらの成果は睡眠の意義の解明や新たな睡眠制御方法の開発につながるものである。

Assessment Rating

Verification Result (Rating)

A+

Research Products

• [Journal Article] Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice (2022)
  • Author(s): Suzuki-Abe Haruka、Sonomura Kazuhiro、Nakata Shinya、Miyanishi Kazuya、Mahmoud Asmaa、Hotta-Hirashima Noriko、Miyoshi Chika、Sato Taka-Aki、Funato Hiromasa、Yanagisawa Masashi
  • Journal Title: Neuroscience Research Volume: 177 Pages: 16-24
  • DOI: 10.1016/j.neures.2021.11.008
  • Peer Reviewed / Open Access
• [Journal Article] Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window (2022)
  • Author(s): Yusuke Murakami, Minori Masaki, Shinichi Miyazaki, Ryosuke Oketani, Yu Hayashi, Masashi Yanagisawa, Sakiko Honjoh, Hideaki Kano
  • Journal Title: Biomedical Optics Express Volume: 13 Issue: 2 Pages: 694-708
  • DOI: 10.1364/boe.446273
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Morning preference is associated with subjective happiness among Japanese female workers: A moderation analysis by sleep characteristics from the SLEPT study (2022)
  • Author(s): Hori Daisuke、Arai Yo、Morita Emi、Ikeda Yu、Muroi Kei、Ishitsuka Mami、Ikeda Tomohiko、Takahashi Tsukasa、Doki Shotaro、Oi Yuichi、Sasahara Shinichiro、Ishihara Asuka、Matsumoto Sumire、Kanbayashi Takashi、Yanagisawa Masashi、Satoh Makoto、Matsuzaki Ichiyo
  • Journal Title: Chronobiology International Volume: 39 Issue: 5 Pages: 690-703
  • DOI: 10.1080/07420528.2022.2028801
  • Peer Reviewed / Open Access
• [Journal Article] Detecting cell assemblies by NMF-based clustering from calcium imaging data (2022)
  • Author(s): Nagayama Mizuo、Aritake Toshimitsu、Hino Hideitsu、Kanda Takeshi、Miyazaki Takehiro、Yanagisawa Masashi、Akaho Shotaro、Murata Noboru
  • Journal Title: Neural Networks Volume: 149 Pages: 29-39
  • DOI: 10.1016/j.neunet.2022.01.023
  • Peer Reviewed / Open Access
• [Journal Article] Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide (2022)
  • Author(s): Nemoto Tsuyoshi、Irukayama‐Tomobe Yoko、Hirose Yuki、Tanaka Hiromu、Takahashi Genki、Takahashi Satoshi、Yanagisawa Masashi、Kanbayashi Takashi
  • Journal Title: Journal of Sleep Research Volume: - Issue: 5 Pages: 1-11
  • DOI: 10.1111/jsr.13556
  • Peer Reviewed / Open Access
• [Journal Article] Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton (2022)
  • Author(s): Tsubasa Hino, Tsuyoshi Saitoh, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 59 Pages: 128530-128530
  • DOI: 10.1016/j.bmcl.2022.128530
  • Peer Reviewed / Open Access
• [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives (2022)
  • Author(s): Katoh Koki、Kutsumura Noriki、Yamamoto Naoshi、Nagumo Yasuyuki、Saitoh Tsuyoshi、Ishikawa Yukiko、Irukayama-Tomobe Yoko、Tanimura Ryuji、Yanagisawa Masashi、Nagase Hiroshi
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 59 Pages: 128550-128550
  • DOI: 10.1016/j.bmcl.2022.128550
  • Peer Reviewed / Open Access
• [Journal Article] Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors (2022)
  • Author(s): Katoh Koki、Yamamoto Naoshi、Ishikawa Yukiko、Irukayama-Tomobe Yoko、Tanimura Ryuji、Saitoh Tsuyoshi、Nagumo Yasuyuki、Kutsumura Noriki、Yanagisawa Masashi、Nagase Hiroshi
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 59 Pages: 128527-128527
  • DOI: 10.1016/j.bmcl.2022.128527
  • Peer Reviewed / Open Access
• [Journal Article] Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring (2022)
  • Author(s): Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kustumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 60 Pages: 128555-128555
  • DOI: 10.1016/j.bmcl.2022.128555
  • Peer Reviewed / Open Access
• [Journal Article] Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APP swe Alzheimer's Disease Mouse Model (2022)
  • Author(s): Marta Zamarbide, Eva Martinez-Pinilla, Francisco Gil-Bea, Masashi Yanagisawa, Rafael Franco, Alberto Perez-Mediavilla
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Issue: 7 Pages: 3553-3553
  • DOI: 10.3390/ijms23073533
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders (2021)
  • Author(s): Saito Ryo、Miyoshi Chika、Koebis Michinori、Kushima Itaru、Nakao Kazuki、Mori Daisuke、Ozaki Norio、Funato Hiromasa、Yanagisawa Masashi、Aiba Atsu
  • Journal Title: Molecular Brain Volume: 14 Issue: 1 Pages: 68-68
  • DOI: 10.1186/s13041-021-00778-7
  • Peer Reviewed / Open Access
• [Journal Article] Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice (2021)
  • Author(s): Can Liu, Chia-Ying Lee, Greg Asher, Liqin Cao, Yuka Terakoshi, Peng Cao, Reiko Kobayakawa, Ko Kobayakawa, Katsuyasu Sakurai, Qinghua Liu
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 2648-2648
  • DOI: 10.1038/s41467-021-22914-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolic responses to polychromatic LED and OLED light at night (2021)
  • Author(s): Asuka Ishihara, Insung Park, Yoko Suzuki, Katsuhiko Yajima, Huiyun Cui, Masashi Yanagisawa, Takeshi Sano, Junji Kido, Kumpei Tokuyama
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 12402-12402
  • DOI: 10.1038/s41598-021-91828-6
  • Peer Reviewed / Open Access
• [Journal Article] O-EG004. Comparing the accuracy of sleep staging data from a new wearable sleep electroencephalography device versus the Fitbit Charge 3 with polysomnography as reference (2021)
  • Author(s): Yoko Suzuki, Takashi Abe, Fusae Kawana, Satomi Okabe, Toshio Kokubo, Kazuya Hoshino, Misao Baba, Masaaki Fujiwara, Masashi Yanagisawa
  • Journal Title: Clinical Neurophysiology Volume: 132 Issue: 8 Pages: 67-67
  • DOI: 10.1016/j.clinph.2021.02.125
  • Peer Reviewed / Open Access
• [Journal Article] Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors (2021)
  • Author(s): Tsai Chia-Jung、Nagata Takeshi、Liu Chih-Yao、Suganuma Takaya、Kanda Takeshi、Miyazaki Takehiro、Liu Kai、Saitoh Tsuyoshi、Nagase Hiroshi、Lazarus Michael、Vogt Kaspar E.、Yanagisawa Masashi、Hayashi Yu
  • Journal Title: Cell Reports Volume: 36 Issue: 7 Pages: 109558-109558
  • DOI: 10.1016/j.celrep.2021.109558
  • NAID: 120007141681
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Role of Reproductive Hormones in Sex Differences in Sleep Homeostasis and Arousal Response in Mice (2021)
  • Author(s): Choi Jinhwan、Kim Staci J.、Fujiyama Tomoyuki、Miyoshi Chika、Park Minjeong、Suzuki-Abe Haruka、Yanagisawa Masashi、Funato Hiromasa
  • Journal Title: Frontiers in Neuroscience Volume: 15 Pages: 739236-739236
  • DOI: 10.3389/fnins.2021.739236
  • Peer Reviewed / Open Access
• [Journal Article] GI-SleepNet: A Highly Versatile Image-Based Sleep Classification Using a Deep Learning Algorithm (2021)
  • Author(s): Tianxiang Gao, Jiayi Li, Yuji Watanabe, Cijung Hung, Akihiro Yamanaka, Kazumasa Horie, Masashi Yanagisawa, Masahiro Ohsawa, Kazuhiko Kume
  • Journal Title: Clocks & Sleep Volume: 3 Issue: 4 Pages: 581
  • DOI: 10.3390/clockssleep3040041
  • Peer Reviewed / Open Access
• [Journal Article] Protocol for sleep analysis in the brain of genetically modified adult mice (2021)
  • Author(s): Kanako Iwasaki, Noriko Hotta-Hirashima, Hiromasa Funato, Masashi Yanagisawa
  • Journal Title: STAR Protocols Volume: 2 Issue: 4 Pages: 100982-100982
  • DOI: 10.1016/j.xpro.2021.100982
  • Peer Reviewed / Open Access
• [Journal Article] Induction of narcolepsy-like symptoms by orexin receptor antagonists in mice (2021)
  • Author(s): Kaushik Mahesh K, Aritake Kosuke, Cherasse Yoan, Imanishi Aya, Kanbayashi Takashi, Urade Yoshihiro, Yanagisawa Masashi
  • Journal Title: Sleep Volume: 44 Issue: 8
  • DOI: 10.1093/sleep/zsab043
  • Peer Reviewed
• [Journal Article] An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension (2021)
  • Author(s): Ryanto Gusty R. T.、Ikeda Koji、Miyagawa Kazuya、Tu Ly、Guignabert Christophe、Humbert Marc、Fujiyama Tomoyuki、Yanagisawa Masashi、Hirata Ken-ichi、Emoto Noriaki
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 1730-1734
  • DOI: 10.1038/s41467-021-21961-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Induction of Mutant Sik3Sleepy Allele in Neurons in Late Infancy Increases Sleep Need (2021)
  • Author(s): Iwasaki Kanako, Fujiyama Tomoyuki, Nakata Shinya, Park Minjeong, Miyoshi Chika, Hotta-Hirashima Noriko, Ikkyu Aya, Kakizaki Miyo, Sugiyama Fumihiro, Mizuno Seiya, Abe Manabu, Sakimura Kenji, Takahashi Satoru, Funato Hiromasa, Yanagisawa Masashi
  • Journal Title: The Journal of Neuroscience Volume: 41 Issue: 12 Pages: 2733-2746
  • DOI: 10.1523/jneurosci.1004-20.2020
  • Peer Reviewed / Open Access
• [Journal Article] Forward genetic approach for behavioral neuroscience using animal models (2020)
  • Author(s): Hiromasa Funato
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 96 Issue: 1 Pages: 10-31
  • DOI: 10.2183/pjab.96.002
  • NAID: 130007783761
  • ISSN: 0386-2208, 1349-2896
  • Year and Date: 2020-01-10
  • Peer Reviewed / Open Access
• [Journal Article] Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice. (2020)
  • Author(s): Kashiwagi M, Kanuka M, Tatsuzawa C, Suzuki H, Morita M, Tanaka K, Kawano T, Shin JW, Suzuki H, Itohara S, Yanagisawa M, Hayashi Y.
  • Journal Title: Curr Biol. Volume: 30 Issue: 6 Pages: 1002-1010
  • DOI: 10.1016/j.cub.2020.01.047
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Loss of Arc attenuates the behavioral and molecular responses for sleep homeostasis in mice (2020)
  • Author(s): Suzuki Ayako, Yanagisawa Masashi, Greene Robert W.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 117 Issue: 19 Pages: 10547-10553
  • DOI: 10.1073/pnas.1906840117
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need (2020)
  • Author(s): Park Minjeong, Miyoshi Chika, Fujiyama Tomoyuki, Kakizaki Miyo, Ikkyu Aya, Honda Takato, Choi Jinhwan, Asano Fuyuki, Mizuno Seiya, Takahashi Satoru, Yanagisawa Masashi, Funato Hiromasa
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 8676-8676
  • DOI: 10.1038/s41598-020-65647-0
  • NAID: 120007163335
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• [Journal Article] Dynamics of Cortical Local Connectivity during Sleep-Wake States and the Homeostatic Process (2020)
  • Author(s): Takehiro Miyazaki, Takeshi Kanda, Natsuko Tsujino, Ryo Ishii, Daiki Nakatsuka, Mariko Kizuka, Yasuhiro Kasagi, Hideitsu Hino, Masashi Yanagisawa
  • Journal Title: Cerebral Cortex Volume: online Issue: 7 Pages: 3977-3990
  • DOI: 10.1093/cercor/bhaa012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction (2020)
  • Author(s): Honda Takato, Takata Yohko, Cherasse Yoan, Mizuno Seiya, Sugiyama Fumihiro, Takahashi Satoru, Funato Hiromasa, Yanagisawa Masashi, Lazarus Michael, Oishi Yo
  • Journal Title: iScience Volume: 23 Issue: 6 Pages: 101240-101240
  • DOI: 10.1016/j.isci.2020.101240
  • NAID: 120007163338
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• [Journal Article] Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo. (2020)
  • Author(s): Omori S, Wang TW, Johmura Y, ..., Sakamoto T (15番目), ..., Nakanishi M.
  • Journal Title: Cell Metab Volume: 32 Issue: 5 Pages: 814-828
  • DOI: 10.1016/j.cmet.2020.09.006
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• [Journal Article] Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice (2020)
  • Author(s): Yukino Ogawa, Chika Miyoshi, Nozomu Obana, Kaho Yajima, Noriko Hotta-Hirashima, Aya Ikkyu, Satomi Kanno, Tomoyoshi Soga, Shinji Fukuda & Masashi Yanagisawa
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 19554-19554
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• [Journal Article] Enhanced cortical responsiveness during natural sleep in freely behaving mice. (2020)
  • Author(s): Matsumoto S, Ohyama K, Diaz J, Yanagisawa M, Greene RW, Vogt KE.
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• [Journal Article] a-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia:a prodromal Parkinson’s disease model (2020)
  • Author(s): Taguchi T, Ikuno M, Hondo M, Parajuli LK, Taguchi K, Ueda J, Sawamura M, Okuda S, Nakanishi E, Hara J, Uemura N, Hatanaka Y, Ayaki T, Matsuzawa S, Tanaka M, El-Agnaf OMA, Koike M, Yanagisawa M, Uemura MT, Yamakado H, Takahashi R
  • Journal Title: BRAIN Volume: 143 Issue: 1 Pages: 249-265
  • DOI: 10.1093/brain/awz380
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• [Journal Article] Distinct effects of orexin receptor antagonist and GABA(A) agonist on sleep and physical/cognitive functions after forced awakening. (2019)
  • Author(s): Seol J, Fujii Y, Park I, Suzuki Y, Kawana F, Yajima K, Fukusumi S, Okura T, Satoh M, Tokuyama K, Kokubo T, Yanagisawa M.
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• [Journal Article] Effects of 3 Weeks of Water Immersion and Restraint Stress on Sleep in Mice. (2019)
  • Author(s): Yasugaki S, Liu CY, Kashiwagi M, Kanuka M, Honda T, Miyata S, Yanagisawa M, Hayashi Y.
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  • DOI: 10.3389/fnins.2019.01072
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• [Journal Article] Endothelin: 30 Years From Discovery to Therapy. (2019)
  • Author(s): Barton M, Yanagisawa M.
  • Journal Title: Hypertension. Volume: 74 Issue: 6 Pages: 1232-1265
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• [Journal Article] MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks. (2019)
  • Author(s): Yamabe M, Horie K, Shiokawa H, Funato H, Yanagisawa M, Kitagawa H.
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  • DOI: 10.1038/s41598-019-51269-8
  • NAID: 120007127675
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• [Journal Article] Differential Roles of Each Orexin Receptor Signaling in Obesity (2019)
  • Author(s): Kakizaki Miyo、Tsuneoka Yousuke、Takase Kenkichi、Kim Staci J.、Choi Jinhwan、Ikkyu Aya、Abe Manabu、Sakimura Kenji、Yanagisawa Masashi、Funato Hiromasa
  • Journal Title: iScience Volume: 20 Pages: 1-13
  • DOI: 10.1016/j.isci.2019.09.003
  • NAID: 120007132695
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• [Journal Article] Neuronal Myocyte-Specific Enhancer Factor 2D (MEF2D) Is Required for Normal Circadian and Sleep Behavior in Mice. (2019)
  • Author(s): Mohawk JA, Cox KH, Sato M, Yoo SH, Yanagisawa M, Olson EN, Takahashi JS.
  • Journal Title: J Neurosci. Volume: 39 Issue: 40 Pages: 7958-7967
  • DOI: 10.1523/jneurosci.0411-19.2019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain. (2019)
  • Author(s): Furuse T, Mizuma H, Hirose Y, Kushida T, Yamada I, Miura I, Masuya H, Funato H, Yanagisawa M, Onoe H, Wakana S.
  • Journal Title: Dis Model Mech. Volume: 12 Issue: 9 Pages: 38828-38828
  • DOI: 10.1242/dmm.038828
  • NAID: 120007161317
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity. (2019)
  • Author(s): Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 29 Issue: 18 Pages: 2655-2658
  • DOI: 10.1016/j.bmcl.2019.07.039
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice. (2019)
  • Author(s): Miyoshi C, Kim SJ, Ezaki T, Ikkyu A, Hotta-Hirashima N, Kanno S, Kakizaki M, Yamada M, Wakana S, Yanagisawa M, Funato H
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 116 Issue: 32 Pages: 16062-16067
  • DOI: 10.1073/pnas.1906774116
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring (2019)
  • Author(s): Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 27 Issue: 8 Pages: 1747-1758
  • DOI: 10.1016/j.bmc.2019.03.010
  • Peer Reviewed / Open Access
• [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity. (2019)
  • Author(s): Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 29 Issue: 3 Pages: 26552658-26552658
  • DOI: 10.1016/j.bmcl.2019.126893
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypocretin/orexin deficiency decreases cocaine abuse liability (2018)
  • Author(s): Steiner Nadia、Rossetti Clara、Sakurai Takeshi、Yanagisawa Masashi、de Lecea Luis、Magistretti Pierre J.、Halfon Olivier、Boutrel Benjamin
  • Journal Title: Neuropharmacology Volume: 133 Pages: 395-403
  • DOI: 10.1016/j.neuropharm.2018.02.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice (2018)
  • Author(s): Saitoh Akiyoshi、Tominaga Hiromu、Ogawa Yasuhiro、Irukayama-Tomobe Yoko、Yamada Mitsuhiko、Yanagisawa Masashi、Nagase Hiroshi
  • Journal Title: Pharmacological Reports Volume: 70 Issue: 2 Pages: 350-354
  • DOI: 10.1016/j.pharep.2017.08.018
• [Journal Article] Localization of orexin B and orexin-2 receptor in the rat epididymis (2018)
  • Author(s): Liguori Giovanna、Tafuri Simona、Miyoshi Chika、Yanagisawa Masashi、Squillacioti Caterina、De Pasquale Valeria、Mirabella Nicola、Vittoria Alfredo、Costagliola Anna
  • Journal Title: Acta Histochemica Volume: 120 Issue: 3 Pages: 292-297
  • DOI: 10.1016/j.acthis.2018.02.011
• [Journal Article] Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats (2018)
  • Author(s): Toyama, S., Shimoyama N, Tagaito Y., Nagase H., Saitoh T., Yanagisawa M., and Shimoyama, M.
  • Journal Title: Anesthesiology Volume: 128 Issue: 5 Pages: 992
  • DOI: 10.1097/aln.0000000000002161
  • Peer Reviewed
• [Journal Article] Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy (2018)
  • Author(s): Kaushik Mahesh K.、Aritake Kosuke、Imanishi Aya、Kanbayashi Takashi、Ichikawa Tadashi、Shimizu Tetsuo、Urade Yoshihiro、Yanagisawa Masashi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Issue: 23 Pages: 6046-6051
  • DOI: 10.1073/pnas.1722686115
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative phosphoproteomic analysis of the molecular substrates of sleep need (2018)
  • Author(s): Z. Wang, J. Ma, C. Miyoshi, Y. Li, M Sato, Y. Ogawa, T. Lou, C. Ma, X. Gao, C. Lee, T. Fujiyama, X. Yang, S. Zhou, N. Hotta-Hirashima, D. Klewe-Nebenus, A. Ikkyu, M. Kakizaki, S. Kanno, L. Cao, S. Takahashi, J. Peng, Y. Yu, H. Funato, M. Yanagisawa, Q. Liu
  • Journal Title: Nature Volume: 558 Issue: 7710 Pages: 435-439
  • DOI: 10.1038/s41586-018-0218-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice (2018)
  • Author(s): Honda Takato、Fujiyama Tomoyuki、Miyoshi Chika、Ikkyu Aya、Hotta-Hirashima Noriko、Kanno Satomi、Mizuno Seiya、Sugiyama Fumihiro、Takahashi Satoru、Funato Hiromasa、Yanagisawa Masashi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Issue: 41 Pages: 10458-10463
  • DOI: 10.1073/pnas.1810823115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response (2018)
  • Author(s): Iwasaki Kanako、Komiya Haruna、Kakizaki Miyo、Miyoshi Chika、Abe Manabu、Sakimura Kenji、Funato Hiromasa、Yanagisawa Masashi
  • Journal Title: Frontiers in Neuroscience Volume: 12 Pages: 535-535
  • DOI: 10.3389/fnins.2018.00535
  • NAID: 120007133025
  • Peer Reviewed / Open Access
• [Journal Article] Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors (2018)
  • Author(s): Wang, Y., Cao, L., Lee, C-Y., Matsuo, M., Wu, K., Asher, G., Saitoh, T., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Cherasse, Y., Miyoshi,C., Irukayama, Y., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B., Liu, Q
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 2041-2041
  • DOI: 10.1038/s41467-018-04324-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity (2018)
  • Author(s): Ohrui Sayaka、Yamamoto Naoshi、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
  • Journal Title: Bioorg Med Chem Lett. Volume: 28 Issue: 4 Pages: 774-777
  • DOI: 10.1016/j.bmcl.2017.12.069
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models (2017)
  • Author(s): Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 114 Issue: 22 Pages: 5731-5736
  • DOI: 10.1073/pnas.1700499114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Octacosanol restores stress-affected sleep in mice by alleviating stress (2017)
  • Author(s): Kaushik Mahesh K.、Aritake Kosuke、Takeuchi Atsuko、Yanagisawa Masashi、Urade Yoshihiro
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 8892-8892
  • DOI: 10.1038/s41598-017-08874-2
  • NAID: 120007134871
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor (2017)
  • Author(s): Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
  • Journal Title: Bioorg Med Chem Lett. Volume: 27 Issue: 17 Pages: 4176-4179
  • DOI: 10.1016/j.bmcl.2017.07.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates (2017)
  • Author(s): Ogawa Yukino、Kanda Takeshi、Vogt Kaspar、Yanagisawa Masashi
  • Journal Title: J. Comp. Neurol. Volume: 525 Issue: 18 Pages: 3809-3820
  • DOI: 10.1002/cne.24261
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sleep/Wake Behaviors in Mice During Pregnancy and Pregnancy-Associated Hypertensive Mice (2017)
  • Author(s): Komiya Haruna、Miyoshi Chika、Iwasaki Kanako、Hotta-Hirashima Noriko、Ikkyu Aya、Kanno Satomi、Honda Takato、Gosho Masahiko、Hamada Hiromi、Satoh Toyomi、Fukamizu Akiyoshi、Funato Hiromasa、Yanagisawa Masashi
  • Journal Title: Sleep Volume: 41 Issue: 3 Pages: 1-1
  • DOI: 10.1093/sleep/zsx209
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 脳状態と脳機能を結ぶ大脳皮質局所機能的ネットワークのダイナミクス (2022)
  • Author(s): 上田壮志
  • Organizer: 行動生理学 特別セミナー
• [Presentation] 睡眠の謎に挑む～原理の追求から社会実装まで～ (2022)
  • Author(s): 柳沢正史
  • Organizer: 山梨医学フォーラム,山梨大学
  • Invited
• [Presentation] 睡眠の謎に挑む～『眠気』の実体を求めて～ (2022)
  • Author(s): 柳沢正史
  • Organizer: 筑波大学生命科学動物資源センター 20周年記念シンポジウム,筑波大学
  • Invited
• [Presentation] 睡眠の謎に挑む～『眠気』の実体を求めて～ (2022)
  • Author(s): 柳沢正史
  • Organizer: 第95回日本薬理学会年会,福岡国際会議場
  • Int'l Joint Research / Invited
• [Presentation] レム睡眠制御の分子機構：近位依存性ビオチン標識法BioIDを用いた電位非依存性陽イオンチャネルNALCNのタンパク質間相互作用因子の探索 (2022)
  • Author(s): 藤山知之, 山元ひかり, 北園智弘, 一久綾, 管野里美, 柿﨑美代, Choi Jinhwan, 中田慎也, 村田知弥, 水野聖哉, 杉山文博, 高橋智, 船戸弘正, 柳沢正史
  • Organizer: 第95回日本薬理学会年会
  • Int'l Joint Research
• [Presentation] Distinct network structures emerge in the primary motor cortex during active and quiet wake (2022)
  • Author(s): Takeshi Kanda, Takehiro Miyazaki, Kotaro Sakamoto, Hideitsu hino, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会
  • Int'l Joint Research
• [Presentation] Establishment of a Model Mouse Pedigree with hypersomnia and obesity by EEG/EMG-Based Forward Genetic Screening (2022)
  • Author(s): 三好千香, 堀田範子, 管野里美, 一久綾, 柿﨑美代, 柳沢正史, 船戸弘正
  • Organizer: 第99回日本生理学会
  • Int'l Joint Research
• [Presentation] Loss of canonical Hdac4 signaling leads to dysregulated sleep (2022)
  • Author(s): Staci J. Kim
  • Organizer: 第99回日本生理学会 JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] NALCN in the forebrain and pons-medulla regions have distinct roles in REM sleep regulation (2022)
  • Author(s): Tomoyuki Fujiyama, Satomi Kanno, Noriko Hirashima Hotta, Miyo Kakizaki, Aya Ikkyu, Yosuke Tsuneoka, Manabu Abe, Ayako Mochizuki, Patricia Seoane-Collazo, Takehiro Miyazaki, Seiya Mizuno, Chika Miyoshi, Takeshi Kanda, Masahiko Watanabe, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Natural history study of sleep disturbances in CDKL5 deficiency disorder mice (2022)
  • Author(s): Cao Liqin, Tingting Lou, Xin Zhang, Jing Ma, Zhiqiang Wang, Teruyuki Tanaka, Hiromasa Funato, Qinghua Liu, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Learning and memory deficit in adult dreamless mice (2022)
  • Author(s): Deependra Kumar, Tomoyuki Fujiyama, Takeshi Kanda, Chika Miyoshi, Miyo Kakizaki, Masanori Sakaguchi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Pre-narcoleptics are more prone to suvorexant-induced cataplexy. (2022)
  • Author(s): Mahesh K. Kaushik, Kosuke Aritake, Yoan Cherasse, Aya Imanishi, Takeshi Kanbayashi, Yoshihiro Urade, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Orexin receptor antagonists ameliorate the symptoms of REM sleep behavior disorder in a novel mouse model and in human patients (2022)
  • Author(s): Mari Hondo, Takuro Endo, Ayako Mochizuki, Masanori Dantsuji, Takeshi Kanda, Makito Sato, Fusae Kawana, Yukiko Ishikawa, Kazue Suenaga, Shiro Nakamura, Manabu Abe, Tomio Inoue, Kenji Sakimura, Hiromasa Funato, Takeshi Sakurai, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Sleep/wakefulness and body weight growth from infancy to adulthood in a hypersomnia model, Sleepy mutant mouse. (2022)
  • Author(s): Noriko Hotta-Hirashima, Chika Miyoshi, Aya Ikkyu, Miyo Kakizaki, Satomi Kanno, Kumi Ebihara, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] The novel intracellular signaling pathways for the regulation of homeostatic sleep need (2022)
  • Author(s): Tomohiro Kitazono, Noriko Hotta-Hirashima, Kanako Iwasaki, Tomoyuki Fujiyama, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] SIK3 in different hypothalamic areas mediates whole-body energy balance (2022)
  • Author(s): Patricia Seoane-Collazo, Masashi Yanagisawa, Hiromasa Funato
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Sik3 regulates sleep need via glutamatergic neurons in cerebral cortex (2022)
  • Author(s): Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Tomohiro Kitazono, Noriko Hotta-Hirashima, Miyo Kakizaki, Aya Ikkyu, Satomi Kanno, Shinya Nakata, Nodoka Asama, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Where does Sleepy mutation of SIK3 cause sleep phenotypes? (2022)
  • Author(s): Kanako Iwasaki, Tomoyuki Fujiyama, Shinya Nakata, Minjeong Park, Chika Miyoshi, Noriko Hotta-Hirashima, Aya Ikkyu, Miyo Kakizaki, Yukiko Ishikawa, Fumihiro Sugiyama, Seiya Mizuno, Manabu Abe, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Sleep/wake behavior of mice lacking PKA phosphorylation site in SIK3 (2022)
  • Author(s): Minjeong Park, Takato Honda, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Molecular mechanisms for SIK3(Sleepy)-mediated sleep/wake regulation (2022)
  • Author(s): Shinya Nakata, Haruna Abe-Komiya, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Fuyuki Asano, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] OX2R-selective orexin agonism is sufficient to suppress narcoleptic symptoms, cataplexy and wake fragmentation, without inducing drug-seeking behavior in mouse models (2022)
  • Author(s): Hikari Yamamoto, Yasuyuki Nagumo, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Tsuyoshi Nemoto, Hiromu Tanaka, Genki Takahashi, Akihisa Tokuda, Tsuyoshi Saitoh, Hiroshi Nagase, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Automatic assessment of sleep recordings from a portable IoT EEG device. (2022)
  • Author(s): Juan Carlos Neira, Leo Ota, Kazumasa Horie, Masashi Yanagisawa, Hiroyuki Kitagawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice (2022)
  • Author(s): Haruka Suzuki-Abe, Kazuhiro Sonomura, Shinya Nakata, Kazuya Miyanishi, AsmaaMahmoud, Noriko Hotta-Hirashima, Chika Miyoshi, Taka-Aki Sato, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] Sleepy mouse as a model of idiopathic hypersomnia (2022)
  • Author(s): Asmaa Elhosainy Mohamed Mahmoud, Haruka Suzuki-Abe, Mahesh Kaushik, Staci Jakyong Kim, Tsuyoshi Saitoh, Yukiko Ishikawa, Noriko HottaHirashima, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
  • Int'l Joint Research
• [Presentation] 睡眠覚醒の謎に挑む～原理の追求から社会実装まで～ (2022)
  • Author(s): 柳沢正史
  • Organizer: 第49回日本集中治療医学会学術集会,仙台国際センター
  • Int'l Joint Research / Invited
• [Presentation] Deciphering the mystery of sleep: toward the molecular substrate for "sleepiness" (2022)
  • Author(s): 柳沢正史
  • Organizer: 2nd China Narcolepsy and International Hypersomnolence Meeting,Chinese Sleep Research Society
  • Int'l Joint Research / Invited
• [Presentation] Young Neurons Role in Consolidating Memory during REM Sleep (2022)
  • Author(s): Deependra Kumar
  • Organizer: Annual Symposium of the Federation of Indian Physiological Society 2022 (FIPS-22) International Virtual Conference
  • Int'l Joint Research
• [Presentation] 睡眠覚醒の謎に挑む ～原理の追求から社会実装まで～ (2021)
  • Author(s): 柳沢正史
  • Organizer: （オンライン）ACT-541468 Investigators Meeting(Daridorexant)
  • Invited
• [Presentation] Toward the Molecular Basis of Sleepness (2021)
  • Author(s): 柳沢正史
  • Organizer: (オンライン)ASSM2021
  • Int'l Joint Research / Invited
• [Presentation] 睡眠覚醒の謎に挑む (2021)
  • Author(s): 柳沢正史
  • Organizer: (オンライン)第68回日本実験動物学会総会
  • Int'l Joint Research / Invited
• [Presentation] 睡眠覚醒の謎に挑む (2021)
  • Author(s): 柳沢正史
  • Organizer: 第62回日本神経学会学術大会, 国立京都国際会館
  • Int'l Joint Research / Invited
• [Presentation] 睡眠覚醒の謎に挑む (2021)
  • Author(s): 柳沢正史
  • Organizer: (オンライン)第68回日本麻酔科学会学術集会
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む～原理の追求から社会実装まで～ (2021)
  • Author(s): 柳沢正史
  • Organizer: (オンライン)第32回日本老年学会総会
  • Int'l Joint Research / Invited
• [Presentation] 睡眠と覚醒 (2021)
  • Author(s): 柳沢正史
  • Organizer: (オンライン)慶應義塾大学医学部医学部生理学特別講義
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2021)
  • Author(s): 柳沢正史
  • Organizer: 令和３年金沢大学十全医学会総会・学術集会,金沢大学十全講堂
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2021)
  • Author(s): 柳沢正史
  • Organizer: 第48回日本毒性学会学術年会, 神戸国際会議場
  • Int'l Joint Research / Invited
• [Presentation] 恒常的睡眠要求を制御する新規シグナル伝達経路の探索 (2021)
  • Author(s): 北園智弘, 堀田範子, 岩崎加奈子, 藤山知之, 船戸弘正, 柳沢正史
  • Organizer: 第44回日本神経科学大会・CJK第1回国際会議
  • Int'l Joint Research
• [Presentation] The impact of social environment on sleep architecture in mice (2021)
  • Author(s): Minjeong Park, 櫻井勝康, 船戸弘正, 柳沢正史
  • Organizer: 第44回日本神経科学大会・CJK第1回国際会議
  • Int'l Joint Research
• [Presentation] Endogenous SIK3 regulates sleep need through glutamatergic neurons in cerebral cortex (2021)
  • Author(s): 浅野冬樹, 藤山智之, 三好千香,北園智弘, 堀田範子, 柿﨑美代, 一久綾, 管野里美, 中田慎也, 浅間のどか, 水野聖哉, 杉山文博, 高橋智, 船戸弘正, 柳沢正史
  • Organizer: 第44回日本神経科学大会・CJK第1回国際会議
  • Int'l Joint Research
• [Presentation] Neuroanatomical and biochemical analysis of how the Sleepy mutant of SIK3 increases sleep (2021)
  • Author(s): 岩崎加奈子, 藤山智之, 上田壮志, 中田慎也, Minjeong Park, 三好千香, 堀田範子, 一久綾, 柿﨑美代, 杉山文博, 水野聖哉, 阿部学, 崎村健司, 高橋智, 松田道行, 船戸弘正, 柳沢正史
  • Organizer: 第44回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Phosphorylation-deficient Sleepy2 mutant mice exhibited decreased NREM sleep (2021)
  • Author(s): 浅間のどか, Staci J. Kim, 藤山智之, 浅野冬樹, 三好千香, 堀田範子, 柿﨑美代, 一久綾, 管野里美, 中田慎也, 水野聖哉, 高橋智, 船戸弘正, 柳沢正史
  • Organizer: 第44回日本神経科学大会・CJK第1回国際会議
  • Int'l Joint Research
• [Presentation] The maturation of sleep homeostasis during development (2021)
  • Author(s): 片山璃沙子, 堀田範子, 三好千香, 一久綾, 管野里美, 海老原恭美, 船戸弘正, 柳沢正史
  • Organizer: 第44回日本神経科学大会・CJK第1回国際会議
  • Int'l Joint Research
• [Presentation] Loss of Sleepy2 in Foxd1 lineage of cells leads to gross abnormality in skull and growth retardation (2021)
  • Author(s): Staci Jakyong Kim , 三好千香, 堀田範子, 管野里美, 柿﨑美代, 一久綾, 船戸弘正, 柳沢正史
  • Organizer: （オンライン）第44回日本神経科学大会・CJK第1回国際会議
  • Int'l Joint Research
• [Presentation] The functional analysis of SIK3 kinase activity for sleep/wake regulation (2021)
  • Author(s): 中田慎也, 小宮春奈, 藤山智之, 三好千香, 一久綾, 浅野冬樹, 水野聖哉, 杉山文博, 高橋智, 船戸弘正, 柳沢正史
  • Organizer: 第44回日本神経科学大会・CJK第1回国際会議
  • Int'l Joint Research
• [Presentation] 睡眠の謎に挑む～原理の追求から社会実装まで～ (2021)
  • Author(s): 柳沢正史
  • Organizer: (オンライン)AMED 再生・細胞医療・遺伝子治療研究交流会
  • Invited
• [Presentation] Similar structures emerge in local cortical networks during quiet wake and NREM sleep (2021)
  • Author(s): 上田壮志, 宮崎峻弘, 坂本航太郎, 日野英逸, 柳沢正史
  • Organizer: 第31回日本神経回路学会
  • Int'l Joint Research
• [Presentation] 睡眠多様性：最先端の神経科学『ノンレム睡眠を制御する細胞内シグナル伝達系の解明』 (2021)
  • Author(s): 柳沢正史, 林悠, Sam Reiter, 乘本裕明, 船戸弘正, 長谷川恵美
  • Organizer: 日本睡眠学会第46回定期学術集会,福岡国際会議場
  • Int'l Joint Research / Invited
• [Presentation] Molecular mechanisms for SIK3(Sleepy)-mediated sleep/wake regulation (2021)
  • Author(s): Shinya Nakata, Haruna Abe-Komiya, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Fuyuki Asano, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Tsukuba Conference 2021（筑波会議2021）
  • Int'l Joint Research
• [Presentation] Advanced techniques in neuroscience research (Optogenetics/neural imaging/unit recording) (2021)
  • Author(s): Deependra Kumar
  • Organizer: Academic Interaction with student in department of Physiology AIIMS, New Delhi.
  • Int'l Joint Research
• [Presentation] Deciphering the mystery of sleep: toward the molecular substrate for sleepiness (2021)
  • Author(s): 柳沢正史
  • Organizer: Brain States and Beyond,Center for Translational Neuromedicine,University of Copenhagen
  • Int'l Joint Research / Invited
• [Presentation] Deciphering the Mystery of Sleep: From the Discovery of Orexin to Forward Genetics in Mice (2021)
  • Author(s): 柳沢正史
  • Organizer: Orexin Science Summit 2021,Idorsia Pharmaceuticals Ltd.
  • Int'l Joint Research / Invited
• [Presentation] 睡眠覚醒の謎に挑む～マウスforward geneticsを武器として～ (2021)
  • Author(s): 柳沢正史
  • Organizer: 理化学研究所バイオリソース研究センター設立20周年記念シンポジウム,理化学研究所
  • Invited
• [Presentation] 「眠気」を制御する新規シグナル伝達経路の探索と解析 (2021)
  • Author(s): 北園智弘
  • Organizer: 第94回日本生化学大会
  • Int'l Joint Research
• [Presentation] Perturbation in Hdac4 signaling leads to dysregulated NREMS (2021)
  • Author(s): Staci J. Kim, Noriko Hotta-Hirashima, Nodoka Asama, Taeko Matsuoka, Tomoyuki Fujiyama, Aya Ikkyu, Miyo Kakizaki, Satomi Kanno, Sseiya Mizuno, Satoru Takahashi, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: SFN Neuroscience 2021 50th Annual Meeting participation
  • Int'l Joint Research
• [Presentation] Involvement of microglia in sleep/wake regulation under acute social defeat stress in mice (2021)
  • Author(s): Kazuya Miyanishi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: NEUROSCIENCE 2021
  • Int'l Joint Research
• [Presentation] Special Lecture - The Mysteries of Sleep - Toward the Molecular Substrate for "Sleepiness" (2021)
  • Author(s): 柳沢正史
  • Organizer: Sosiety for Neuroscience 2021,SfN
  • Int'l Joint Research / Invited
• [Presentation] Where does Sleepy mutation of SIK3 increase non-REM sleep? (2021)
  • Author(s): Kanako Iwasaki, Tomoyuki Fujiyama, Shinya Nakata, Minjeong Park, Chika Miyoshi, Noriko Hotta-Hirashima, Aya Ikkyu, Miyo Kakizaki, Yukiko Ishikawa, Fumihiro Sugiyama, Seiya Mizuno, Manabu Abe, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: NEUROSCIENCE 2021
  • Int'l Joint Research
• [Presentation] Sik3 regulates sleep need via glutamatergic neurons in cerebral cortex in mice (2021)
  • Author(s): Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Tomohiro Kitazono, Noriko Hotta-Hirashima, Miyo Kakizaki, Aya Ikkyu, Satomi Kanno, Shinya Nakata, Nodoka Asama, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: NEUROSCIENCE 2021
  • Int'l Joint Research
• [Presentation] Why is REM sleep Important? (2021)
  • Author(s): Deependra Kumar
  • Organizer: 12th Indian Scientists Association in Japan (ISAJ) symposium
  • Int'l Joint Research
• [Presentation] 『眠気』の正体を求めて (2021)
  • Author(s): 柳沢正史
  • Organizer: 第44回日本分子生物学会,パシフィコ横浜
  • Int'l Joint Research / Invited
• [Presentation] Molecular mechanisms of REM sleep regulation: identifying protein-protein interactions of NALCN channel through BioID technique (2021)
  • Author(s): Hikari Yamamoto, Tomoyuki Fujiyama, Tomohiro Kitazono, Aya Ikkyu, Satomi Kanno, Miyo Kakizaki, Choi Jinhwan, Shinya Nakata, Kazuya Murata, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第44回日本分子生物学会年会
  • Int'l Joint Research
• [Presentation] 睡眠の謎に挑む～原理の追求から社会実装まで～ (2021)
  • Author(s): 柳沢正史
  • Organizer: 第49回獨協医学学術集会,獨協大学
  • Invited
• [Presentation] 潜在的睡眠改善食品の新規睡眠イメージング技術による探索 (2021)
  • Author(s): 上田壮志
  • Organizer: 糧食研究会報告会
• [Presentation] Deciphering the mystery of sleep: toward the molecular substrate for sleepiness (2021)
  • Author(s): 柳沢正史
  • Organizer: Grand Rounds to the Massachusetts General Hospital/ Harvard Medical School
  • Int'l Joint Research / Invited
• [Presentation] 睡眠覚醒の謎に挑む～「眠気」の正体を求めて～ (2021)
  • Author(s): 柳沢正史
  • Organizer: CVMW2021合同シンポジウム,第25回日本心血管内分泌代謝学会学術総会 他
  • Int'l Joint Research / Invited
• [Presentation] 睡眠覚醒の謎に挑む (2021)
  • Author(s): 柳沢正史
  • Organizer: 先端創薬科学講座セミナーコース2021
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2021)
  • Author(s): 柳沢正史
  • Organizer: 第30回日本呼吸ケア・リハビリテーション学会学術集会
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2021)
  • Author(s): 柳沢正史
  • Organizer: 第101春季年会 市民公開講座 夢をかなえる科学
  • Invited
• [Presentation] Intracellular signals in the regulation of sleep/wakefulness (2021)
  • Author(s): 船戸弘正
  • Organizer: 第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会 合同大会
  • Invited
• [Presentation] Sparse functional connectivity of cortical neurons during sleep revealed by calcium imaging and graphical lasso (2021)
  • Author(s): 上田壮志
  • Organizer: 第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会 合同大会
• [Presentation] Molecular Circuits of Homeostatic Sleep Regulation (2020)
  • Author(s): Qinghua Liu
  • Organizer: Society for Research on Biological Rhythm (SRBR) 2020 biennial conference
  • Int'l Joint Research / Invited
• [Presentation] Where does the Nalcn gene take effect in REM sleep regulation? (2020)
  • Author(s): 藤山智之、管野里美、柿﨑美代、一久綾、堀田範子、山田麻奈、岩崎加奈子、浅野冬樹、望月文子、水野聖哉、阿部学、三好千香、上田壮志、崎村健司、高橋智、船戸弘正、柳沢正史
  • Organizer: 第43回日本神経科学大会
• [Presentation] SIK3 regulates sleep need and circadian rhythm through distinct neuronal pathways (2020)
  • Author(s): 浅野冬樹、藤山智之、三好千香、堀田範子、柿﨑美代、一久綾、管野里美、中田慎也、浅間のどか、水野聖哉、杉山文博、高橋智、船戸弘正、柳沢正史
  • Organizer: 第43回日本神経科学大会
• [Presentation] Hypersomnia in mice with induced Sik3Sleepy mutation in late-infancy neurons (2020)
  • Author(s): 岩崎加奈子、藤山智之、三好千香、堀田範子、柿﨑美代、一久綾、管野里美、中田慎也、浅間のどか、水野聖哉、杉山文博、高橋智、船戸弘正、柳沢正史
  • Organizer: 第43回日本神経科学大会
• [Presentation] Production of Sleepy2 StoA mutant mice (2020)
  • Author(s): Nodoka Asama, Staci J. Kim, Tomoyuki Fujiyama, Fuyuki Asano, Chika Miyoshi, Noriko Hotta-Hirashima, Miyo Kakizaki, Aya Ikkyu, Satomi Kanno, Shinya Nakata, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第43回日本神経科学大会
• [Presentation] 睡眠覚醒の謎に挑む (2020)
  • Author(s): 柳沢正史
  • Organizer: 第74回国立病院総合医学会
  • Invited
• [Presentation] Molecular Substrates of Homeostatic Sleep Regulation (2020)
  • Author(s): Qinghua Liu
  • Organizer: 25th Congress of the European Sleep Research Society
  • Int'l Joint Research / Invited
• [Presentation] 睡眠覚醒の謎に挑む (2020)
  • Author(s): 柳沢正史
  • Organizer: 第27回日本時間生物学会学術大会
  • Invited
• [Presentation] OX2R-selective orexin agonism is sufficient to ameliorate narcoleptic symptoms, cataplexy and sleep/wakefulness fragmentation in mouse models (2020)
  • Author(s): Hikari Yamamoto, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yukiko Namekawa, Tsuyoshi Nemoto, Hiromu Tanaka, Genki Takahashi, Akihisa Tokuda, Yasuyuki Nagumo, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Tsukuba Global Science Week 2020
• [Presentation] 睡眠覚醒の謎に挑む (2020)
  • Author(s): 柳沢正史
  • Organizer: 第7回JCRベーシックリサーチカンファレンス
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む～覚醒のために必要な眠り～ (2020)
  • Author(s): 柳沢正史
  • Organizer: 次世代ヘルスケアプロジェクト特別講演会
  • Invited
• [Presentation] Toward the Mystery of Sleep (2020)
  • Author(s): 柳沢正史
  • Organizer: 第1回 IRPA国際シンポジウム
  • Invited
• [Presentation] Sleep/wake behavior of mice expressing a constitutively active form of SIK3 (2020)
  • Author(s): 藤山智之、三好千香、浅野冬樹、中田慎也、一久綾、山田麻奈、Juan Calros Neira Almanza、高橋智、水野聖哉、杉山文博、船戸弘正、柳沢正史
  • Organizer: 第43回日本分子生物学会年会
• [Presentation] フォワードジェネティクス研究による睡眠制御機構の解明 (2020)
  • Author(s): 船戸弘正
  • Organizer: 自治医科大学大学院医学研究科大学院特別講義
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2020)
  • Author(s): 柳沢正史
  • Organizer: 第34回日本糖尿病・肥満動物学会年次学術集会
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2020)
  • Author(s): 柳沢正史
  • Organizer: 第57回睡眠呼吸障害研究会
  • Invited
• [Presentation] SIK family regulates sleep/wakefulness in mice SIKファミリーによる睡眠覚醒制御 (2020)
  • Author(s): 船戸弘正
  • Organizer: 第93回日本薬理学会年会（誌上開催）
• [Presentation] Solving the mysteries of sleep (2019)
  • Author(s): 柳沢正史
  • Organizer: Nature150周年記念イベント The Future of Japanese Science- visions towards achieving the Sustainable Development goals (SDGs)
  • Int'l Joint Research / Invited
• [Presentation] Sleep and energy metabolism regulation though mouse genetics (2019)
  • Author(s): Hiromasa Funato
  • Organizer: CIBR Beijing Conference on Brain & Behavior (China, Beijing) 2019.4.23
  • Int'l Joint Research / Invited
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 柳沢正史
  • Organizer: 第56回日本臨床分子医学会学術集会
  • Invited
• [Presentation] Forward genetics in mice identified novel sleep-regulating genes (2019)
  • Author(s): Hiromasa Funato
  • Organizer: V World Congress of Chronobiology
  • Int'l Joint Research / Invited
• [Presentation] Toward the Mystery of Sleep (2019)
  • Author(s): 柳沢正史
  • Organizer: 10th European Narcolepsy Day, Bern
  • Int'l Joint Research / Invited
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 柳沢正史
  • Organizer: 第19回日本抗加齢医学会総会
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 柳沢正史
  • Organizer: 第42回日本神経科学大会・第62回日本神経化学会大会（NEURO2019
  • Invited
• [Presentation] Where does the Dreamless mutation take effect?: Generation of Nalcn-FLEx and Nalcn-flox Knock-In Mice (2019)
  • Author(s): Tomoyuki Fujiyama, Seiya Mizuno, Manabu Abe, Satomi Kanno, Miyo Kakizaki, Kanako Iwasaki, Aya Ikkyu, Noriko Hirashima Hotta, Mana Yamada, Chika Miyoshi, Makito Sato, Takeshi Kanda, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Neuro2019
  • Int'l Joint Research
• [Presentation] Sleep/wake behavior in mice expressing Sleepy mutant Sik3 specifically in adult brain: analysis using newly developed inducible Cre mice (2019)
  • Author(s): Kanako Iwasaki, Tomoyuki Fujiyama, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Neuro2019
  • Int'l Joint Research
• [Presentation] Electroencephalographic characterization of the Sleepy mutant reveals a multi-spectral disorganization of NREM sleep dynamics accompanied by absence of active wakefulness markers (2019)
  • Author(s): Javier Diaz, Hiromasa Funato, Juan C Letelier, Masashi Yanagisawa, Kaspar E Vogt
  • Organizer: Neuro2019
  • Int'l Joint Research
• [Presentation] Sleep/wakefulness of mice lacking PKA phosphorylation site in SIK1 and SIK2 (2019)
  • Author(s): Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Jinhwan Choi, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Neuro2019
  • Int'l Joint Research
• [Presentation] Molecular mechanism of SIK3-mediated regulation of sleep/wakefulness (2019)
  • Author(s): Shinya Nakata, Tomoyuki Fujiyama, Chika Miyoshi, Satomi Kanno, Aya Ikkyu, Fuyuki Asano, Haruna Komiya, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Neuro2019
  • Int'l Joint Research
• [Presentation] Sleep/wakefulness in neuron subtype-specific SIK3-deficient mice (2019)
  • Author(s): Fuyuki Asano, Chika Miyoshi, Tomoyuki Fujiyama, Noriko Hotta, Miyo Kakizaki, Aya Ikkyu, Satomi Kanno, Shinya Nakata, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Neuro2019
  • Int'l Joint Research
• [Presentation] Identifying schizophrenia genes through a forward genetic screen in mice (2019)
  • Author(s): Liqin Cao, Daniela Klewe-Nebenius, Greg Asher, Chika Miyoshi, Takeshi Sakurai, Hiromasa Funato, Masashi Yanagisawa, Qinghua Liu
  • Organizer: Neuro2019
  • Int'l Joint Research
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 柳沢正史
  • Organizer: 機械の日・機械週間
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 柳沢正史
  • Organizer: 第162回日本獣医学会学術集会
  • Invited
• [Presentation] Toward the Mystery of Sleep (2019)
  • Author(s): 柳沢正史
  • Organizer: Cold Spring Harbor Asia Symposium, China
  • Int'l Joint Research / Invited
• [Presentation] SIKファミリーによる睡眠覚醒とエネルギー代謝制御 (2019)
  • Author(s): 船戸弘正
  • Organizer: 第92回日本生化学学会大会 シンポジウム「行動を制御する脳内分子メカニズムとそのダイナミクス」
• [Presentation] Toward the Mystery of Sleep (2019)
  • Author(s): 柳沢正史
  • Organizer: World Sleep Conference 2019, Canada
  • Int'l Joint Research / Invited
• [Presentation] A step towards demystifying sleep physiology: forward genetics approach in mice (2019)
  • Author(s): Staci Jakyong Kim, Chika Miyoshi, Takahiro Ezaki, Aya Ikkyu, Noriko Hotta-Hirashima, Satomi Kanno, Miyo Kakizaki, Mana Yamada, Shigeharu Wakana, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: IBRO 2019
  • Int'l Joint Research
• [Presentation] Increased sleep need in mice lacking the PKA phosphorylation site in SIK1 and SIK2 (2019)
  • Author(s): Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Jinhwan Choi, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: IBRO 2019
  • Int'l Joint Research
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 柳沢正史
  • Organizer: 第59回日本臨床化学会年次学術集会
  • Invited
• [Presentation] Toward the Mystery of Sleep (2019)
  • Author(s): 柳沢正史
  • Organizer: Korea Society of Molecular and Cellular Biology
  • Int'l Joint Research / Invited
• [Presentation] Examination of sleep/wake behavior in C57BL/6 substrain for forward genetics study in mice (2019)
  • Author(s): Staci Jakyong Kim, Chika Miyoshi, Noriko Hotta-hirashima, Satomi Kanno, Miyo Kakizaki, Masashi Yanagisawa, Hiromasa Funato
  • Organizer: International Conference: Korean Society of Molecular and Cellular Biology 2019
  • Int'l Joint Research
• [Presentation] Sleep/wake in mice expressing a constitutively active form of SIK3 (2019)
  • Author(s): Shinya Nakata, Chika Miyoshi, Takahiro Ezaki, Aya Ikkyu, Noriko Hotta-Hirashima, Satomi Kanno, Miyo Kakizaki, Mana Yamada, Shigeharu Wakana, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Tsukuba Conference 2019
  • Int'l Joint Research
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 船戸弘正
  • Organizer: 第８回日本食品分析センター技術成果発表会
  • Invited
• [Presentation] 神経細胞サブタイプ特異的SIK3欠損マウスの睡眠覚醒 (2019)
  • Author(s): 浅野冬樹、三好千香、藤山知之、堀田範子、柿崎美代、一久綾、管野里美、中田慎也、水野聖哉、杉山文博、高橋智、船戸弘正、柳沢正史
  • Organizer: 第26回日本時間生物学会学術大会
• [Presentation] Where does the Nalcn gene take effect in REM sleep regulation? (2019)
  • Author(s): Tomoyuki Fujiyama, Seiya Mizuno, Manabu Abe, Satomi Kanno, Miyo Kakizaki, Kanako Iwasaki, Aya Ikkyu, Noriko Hirashima Hotta, Mana Yamada, Chika Miyoshi, Makito Sato, Takeshi Kanda, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Neuroscience 2019, Society for Neuroscience
  • Int'l Joint Research
• [Presentation] 内側視索前野における雄性行動関連細胞の機能解剖学的解析 (2019)
  • Author(s): 恒岡洋右、船戸弘正
  • Organizer: 第46回日本神経内分泌学会
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 柳沢正史
  • Organizer: 群馬大学創立70周年記念講演会
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 柳沢正史
  • Organizer: 茨城三大学交流セミナー
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 柳沢正史
  • Organizer: 第26回日本胎盤臨床医学会大会
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2019)
  • Author(s): 柳沢正史
  • Organizer: 第65回日本病理学会秋季特別総会
  • Invited
• [Presentation] The elucidation of the role of SIK3 kinase activity in sleep/wakefulness (2019)
  • Author(s): Shinya Nakata, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Fuyuki Asano, Haruna Komiya, Noriko Hotta-Hirashima, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: The 8th Annual IIIS International Symposium
  • Int'l Joint Research
• [Presentation] Sleep/wakefulness in neuron type-specific SIK3-deficient mice (2019)
  • Author(s): Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Noriko Hotta-Hirashima, Miyo Kakizaki, Aya Ikkyu, Satomi Kanno, Shinya Nakata, Nodoka Asama, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: The 8th Annual IIIS International Symposium
  • Int'l Joint Research
• [Presentation] Increased NREMS in mice expressing mutant Sik3 in postnatal neurons using newly developed Synapsin1CreERT2 mice (2019)
  • Author(s): Kanako Iwasaki, Tomoyuki Fujiyama, Shinya Nakata, Park Minjeong, Noriko Hotta-Hirashima, Fumihiro Sugiyama, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: The 8th Annual IIIS International Symposium
  • Int'l Joint Research
• [Presentation] MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks (2019)
  • Author(s): Kazumasa Horie, Hiroyuki Kitagawa, Masashi Yanagisawa, Hiromasa Funato
  • Organizer: The 8th Annual IIIS International Symposium
  • Int'l Joint Research
• [Presentation] Sleep/wake behavior of mice lacking PKA phosphorylation site in SIK1 and SIK2 (2019)
  • Author(s): Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Takato Honda, Jinhwan Choi, Fuyuki Asano, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: The 8th Annual IIIS International Symposium
  • Int'l Joint Research
• [Presentation] Sleep and obesity of Sik1 S577A and Sik2 S587A mutant mice (2019)
  • Author(s): Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Jinhwan Choi, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第42回分子生物学会年会
  • Int'l Joint Research
• [Presentation] The role of SIK3 kinase activity in sleep/wakefulness (2019)
  • Author(s): Shinya Nakata, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Fuyuki Asano, Haruna Komiya, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第42回分子生物学会年会
  • Int'l Joint Research
• [Presentation] Forward genetic identification of sleep/wakefulness-regulating gene and analysis of Sleepy2-transgeneic mice (2019)
  • Author(s): Jinhwan Choi, Staci J. Kim, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
  • Organizer: 第42回分子生物学会年会
  • Int'l Joint Research
• [Presentation] Analysis of the molecular basis of sleep need through substrate screening for SIK3 (2019)
  • Author(s): 北園智弘、船戸弘正、柳沢正史
  • Organizer: 第42回分子生物学会年会
  • Int'l Joint Research
• [Presentation] Toward the Mysteries of Sleep (2019)
  • Author(s): 柳沢正史
  • Organizer: FAOPS2019 アジア・オセアニア生理学会第9回大会
• [Presentation] Toward the Mysteries of Sleep (2019)
  • Author(s): 柳沢正史
  • Organizer: HKIAS Symposium on Advances in Neuroscience
• [Presentation] 『睡眠覚醒の謎に挑む』 (2018)
  • Author(s): 柳沢正史
  • Organizer: 第91回日本内分泌学会学術総会
• [Presentation] 『睡眠覚醒の謎に挑む』/Toward the Mysteries of Sleep (2018)
  • Author(s): 柳沢正史
  • Organizer: 第41回日本神経科学大会
• [Presentation] 『睡眠覚醒の謎に挑む』 (2018)
  • Author(s): 柳沢正史
  • Organizer: Toyama Academic GALA 2018
• [Presentation] Toward the Mysteries of Sleep / “What makes you sleepy? Elusive molecular substrates for homeostatic sleep need” (2018)
  • Author(s): 柳沢正史
  • Organizer: JAACT2018 The31st Annual and International Meeting of the Japanese Association for Animal Cell Technology
• [Presentation] 『睡眠覚醒の謎に挑む』 (2018)
  • Author(s): 柳沢正史
  • Organizer: 日本睡眠歯科学会第17回学術集会
• [Presentation] Toward the Mysteries of Sleep (2018)
  • Author(s): 柳沢正史
  • Organizer: Cognitive Neurosciene and Learning Annual Conference 2018
• [Presentation] 睡眠覚醒の謎に挑む ~睡眠科学の基礎から社会実装へ~ (2018)
  • Author(s): 柳沢正史
  • Organizer: 第1回産学連携シンポジウム
• [Presentation] Toward the Mysteries of Sleep (2018)
  • Author(s): 柳沢正史
  • Organizer: FAOPS2019 アジア・オセアニア生理学会第9回大会
• [Presentation] 睡眠覚醒の謎に挑む (2018)
  • Author(s): 柳沢正史
  • Organizer: 日本薬学会第139年会
• [Presentation] Toward the Mysteries of Sleep (2018)
  • Author(s): 柳沢 正史
  • Organizer: The 17th Mind Brain Conference, Hamamatsu Japan
  • Int'l Joint Research / Invited
• [Presentation] 睡眠覚醒の謎に挑む (2018)
  • Author(s): 柳沢 正史
  • Organizer: 第一回 三融会・武田神経科学シンポジウム
  • Invited
• [Presentation] Toward the Mysteries of Sleep (2018)
  • Author(s): 柳沢 正史
  • Organizer: 第95回日本生理学会大会
  • Invited
• [Presentation] 睡眠覚醒の謎に挑む (2017)
  • Author(s): 柳沢 正史
  • Organizer: 日本睡眠学会
  • Invited
• [Presentation] Toward the Mysteries of Sleep (2017)
  • Author(s): 柳沢 正史
  • Organizer: Keystone Symposia
  • Int'l Joint Research / Invited
• [Presentation] Imaging Sleep and Wakefulness (2017)
  • Author(s): 柳沢 正史
  • Organizer: 12th Uehara International Symposium2017-Make Life Visible-
  • Int'l Joint Research / Invited
• [Presentation] マウスにおける睡眠のフォワード・ジェネティクス解析 (2017)
  • Author(s): 柳沢 正史
  • Organizer: 日本睡眠学会第42回定期学術集会
  • Invited
• [Presentation] Toward the Mysteries of Sleep (2017)
  • Author(s): 柳沢 正史
  • Organizer: National Institute of Biological Sciences, Beijing (NIBS)
  • Invited
• [Presentation] Towards the mystery of sleep and wakefulness: forward genetic analysis in mice (2017)
  • Author(s): 柳沢 正史
  • Organizer: The 38th International Union of Physiological Sciences(IUPS) World Congress
  • Int'l Joint Research / Invited
• [Presentation] Toward the Mysteries of Sleep (2017)
  • Author(s): 柳沢 正史
  • Organizer: 第1回IRCN国際シンポジウム
  • Int'l Joint Research / Invited
• [Book] 月刊カレントテラピーVol.39 No.3 (2021)
  • Author(s): 柳沢正史
  • Total Pages: 94
  • Publisher: ライフメディコム
  • ISBN: 9784898133255
• [Book] 睡眠学 (2020)
  • Author(s): 柳沢正史, 船戸弘正
  • Total Pages: 712
  • Publisher: 朝倉書店
  • ISBN: 9784254301205
• [Book] ブレインサイエンスレビュー2020 新規睡眠制御分子同定による睡眠覚醒機構の解明を目指して（269-288） (2020)
  • Author(s): 船戸弘正
  • Total Pages: 344
  • Publisher: クバプロ
  • ISBN: 9784878051647
• [Book] 最新醫學『フォワード・ジェネティクスによる睡眠制御とその障害の解明』 (2018)
  • Author(s): 柳沢正史、船戸弘正
  • Total Pages: 154
  • Publisher: 最新医学社
• [Book] 週刊「医学のあゆみ」”睡眠・覚醒制御機構研究の新展開”『”眠気”の実体を探る』 (2017)
  • Author(s): 本多隆利、柳沢正史
  • Total Pages: 124
  • Publisher: 医歯薬出版
• [Book] 人間？機械？ 睡眠・ヒト型ロボット・無人操縦 (2017)
  • Author(s): 柳沢正史、石黒浩、谷口恒、唐津治夢
  • Total Pages: 120
  • Publisher: 丸善プラネット
• [Book] 週刊「医学のあゆみ」”睡眠・覚醒制御機構研究の新展開”『ノンレム睡眠の生理的役割』 (2017)
  • Author(s): 船戸弘正
  • Total Pages: 124
  • Publisher: 医歯薬出版
• [Book] Progress in Medicine2017年8月号 特集“認知症と睡眠”『睡眠と認知機能の基礎：記憶の固定も含めて』 (2017)
  • Author(s): 船戸弘正
  • Total Pages: 100
  • Publisher: ライフ・サイエンス社
• [Remarks] 幼若期以降の神経細胞におけるタンパク質リン酸化酵素の遺伝子変異が眠気を増強する
  • URL: https://wpi-iiis.tsukuba.ac.jp/uploads/sites/2/2021/02/210225yanagisawa.pdf
• [Remarks] 睡眠ステージを自動的に判定する手法を開発～マウス4,200匹の睡眠時生体信号を学習・解析から
  • URL: https://wpi-iiis.tsukuba.ac.jp/japanese/news/1495/
• [Remarks] 「眠気」の生化学的な実態に迫る～睡眠要求を規定するリン酸化蛋白質群の同定
  • URL: https://wpi-iiis.tsukuba.ac.jp/japanese/news/1149/
• [Patent(Industrial Property Rights)] テトラリン誘導体またはその薬学的に許容される酸付加塩 (2019)
  • Inventor(s): 長瀬博、斉藤毅、柳沢正史、入鹿山容子
  • Industrial Property Rights Holder: 筑波大学、テキサス大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019