| Budget Amount *help |
¥565,890,000 (Direct Cost: ¥435,300,000、Indirect Cost: ¥130,590,000)
Fiscal Year 2021: ¥111,800,000 (Direct Cost: ¥86,000,000、Indirect Cost: ¥25,800,000)
Fiscal Year 2020: ¥121,680,000 (Direct Cost: ¥93,600,000、Indirect Cost: ¥28,080,000)
Fiscal Year 2019: ¥111,410,000 (Direct Cost: ¥85,700,000、Indirect Cost: ¥25,710,000)
Fiscal Year 2018: ¥143,000,000 (Direct Cost: ¥110,000,000、Indirect Cost: ¥33,000,000)
Fiscal Year 2017: ¥78,000,000 (Direct Cost: ¥60,000,000、Indirect Cost: ¥18,000,000)
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| Outline of Final Research Achievements |
This study aims at understanding the mechanism of human germ-cell development and promoting the in vitro reconstitution of human germ-cell development, using knowledges obtained from mice and cynomolgus monkeys as models and from human induced pluripotent stem cells (hiPSCs)-based in vitro systems. The key achievements include the elucidation of the mechanism for the female germ-cell sex determination in mice, in vitro reconstitution of entire male germ-cell development from PSCs in mice, elucidation of the X-chromosome dosage compensation program during the development of cynomolgus monkeys, elucidation of the ontogeny of the gonadal somatic cells in mice and monkeys, establishment of a method for long-term in vitro expansion of human primordial germ cell-like cells (hPGCLCs), and induction of human early oocyte-like cells from hiPSCs.
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