| Budget Amount *help |
¥184,470,000 (Direct Cost: ¥141,900,000、Indirect Cost: ¥42,570,000)
Fiscal Year 2021: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2020: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2019: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2018: ¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
Fiscal Year 2017: ¥37,050,000 (Direct Cost: ¥28,500,000、Indirect Cost: ¥8,550,000)
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| Outline of Final Research Achievements |
In this project we further develop three-dimensional (3D) force mapping method for biological molecules such as various proteins by the precise control of the atomic force microscopy (AFM) probe motion as well as the real-time analysis of the response signal, which allows us to visualize 3D molecular recognition forces and other several forces originating from hydration structures and/or charge density of the molecules. Thus, the novel imaging of biomolecular functions based on the physics at solid-liquid interfaces is established, which essentially advances the molecular-scale understanding of the cell physiology.
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