| Budget Amount *help |
¥206,960,000 (Direct Cost: ¥159,200,000、Indirect Cost: ¥47,760,000)
Fiscal Year 2021: ¥31,330,000 (Direct Cost: ¥24,100,000、Indirect Cost: ¥7,230,000)
Fiscal Year 2020: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2019: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2018: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2017: ¥66,430,000 (Direct Cost: ¥51,100,000、Indirect Cost: ¥15,330,000)
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| Outline of Final Research Achievements |
Reactions of organic synthesis can be divided into two major genres. It is a reactant-dominated reaction and a substrate-dominated reaction. By using a Lewis acid catalyst, we developed this substrate-dominated reaction at once. Asymmetric oxidation of bishom allyl alcohol and peptide synthesis, which have been said to be impossible until now, fall into this category. In addition, research on the developed titanium catalyst has made it possible to achieve asymmetric oxidation of bishom allyl alcohol with a selectivity of 98% or more. Furthermore, they were also applied to various remote oxidation reactions. We have demonstrated that such a substrate-dominated reaction is key in peptide synthesis, and completed peptide synthesis without racemization, especially using Ta and Ln catalysts.
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