| Budget Amount *help |
¥204,230,000 (Direct Cost: ¥157,100,000、Indirect Cost: ¥47,130,000)
Fiscal Year 2021: ¥37,830,000 (Direct Cost: ¥29,100,000、Indirect Cost: ¥8,730,000)
Fiscal Year 2020: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2019: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2018: ¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2017: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
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| Outline of Final Research Achievements |
In this study, we aimed to quantitatively evaluate cardiac side effects in drug discovery and established a method to monitor electrophysiological signals of pulsing cardiomyocytes sheets with high spatial and temporal resolutions over a long period of time by utilizing stretchable sensors. We succeeded in the realization of nanofiber-type mesh-structure sensors and ultra-thin sensors having ultra-flexibility and high durability simultaneously. Finally, we demonstrated measuring distributions of electrophysiological signals and mechanical properties in dynamically pulsing cardiomyocyte sheets and quantitatively evaluating the effects of medicine administrations.
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