| Budget Amount *help |
¥206,440,000 (Direct Cost: ¥158,800,000、Indirect Cost: ¥47,640,000)
Fiscal Year 2021: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2020: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2019: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2018: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
Fiscal Year 2017: ¥50,830,000 (Direct Cost: ¥39,100,000、Indirect Cost: ¥11,730,000)
|
|---|
| Outline of Final Research Achievements |
In mice, early odor exposure affects social behaviors later in life. A signaling molecule, Semaphorin 7A, is induced in the odor-responding olfactory neurons in an activity-dependent manner. Plexin C1, a receptor for Sema7A, is expressed in second-order neurons, whose dendrite-localization is restricted to the first week after birth. Sema7A promotes post-synaptic events resulting in glomerular enlargement that causes an increase in sensitivity to the experienced odor. Neonatal odor experience also induces positive responses to the imprinted odor, even when the odor quality is innately aversive. Knockout and rescue experiments indicate that oxytocin in neonates is responsible for imposing positive quality on imprinted memory. If the oxytocin or Sema7A signaling is blocked in neonates, social interactions are impaired as adults. These results give new insights into our understanding of olfactory imprinting and will shed light on the neuro-developmental disorders.
|
