| Budget Amount *help |
¥210,210,000 (Direct Cost: ¥161,700,000、Indirect Cost: ¥48,510,000)
Fiscal Year 2021: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2020: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2019: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2018: ¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2017: ¥79,040,000 (Direct Cost: ¥60,800,000、Indirect Cost: ¥18,240,000)
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| Outline of Final Research Achievements |
Based on the hypothesis that racial differences in carcinogenesis due to driver gene abnormalities are caused by differences in the effects of genetic abnormalities on immune responses, this study examined the effects of genetic abnormalities found in various cancer types on anti-tumor immune responses. We found that genetic abnormalities in cancer cells directly influenced the secretion of chemical mediators and the metabolic environment, thereby creating an immunosuppressive tumor microenvironment that promoted carcinogenesis and cancer progression. Thus, immunosuppressive cells, such as regulatory T cells, were induced, infiltrated and activated in tumor tissues, while effector T cells were inhibited in the same tumor tissues.
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