| Budget Amount *help |
¥204,230,000 (Direct Cost: ¥157,100,000、Indirect Cost: ¥47,130,000)
Fiscal Year 2021: ¥37,830,000 (Direct Cost: ¥29,100,000、Indirect Cost: ¥8,730,000)
Fiscal Year 2020: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2019: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2018: ¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2017: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
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| Outline of Final Research Achievements |
Chromosomes must be stably maintained and propagated through continuous cell divisions for organisms to sustain life. Fukagawa has focused his research particularly on "chromosome segregation," one of the chromosome maintenance mechanisms. The centromere regions on chromosomes captured by spindle microtubules during mitosis are important for chromosome segregation, and this study aimed to understand the chromosome segregation mechanism by elucidating the mechanism of centromere formation. We achieved our goals in three topics: elucidation of the centromere protein binding network, understanding of the genome basis of centromeric region, and elucidation of the structural basis of centromere proteins. Then, we believe that our understanding on centromere formation is progressed.
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