| Budget Amount *help |
¥208,910,000 (Direct Cost: ¥160,700,000、Indirect Cost: ¥48,210,000)
Fiscal Year 2021: ¥30,810,000 (Direct Cost: ¥23,700,000、Indirect Cost: ¥7,110,000)
Fiscal Year 2020: ¥29,640,000 (Direct Cost: ¥22,800,000、Indirect Cost: ¥6,840,000)
Fiscal Year 2019: ¥31,460,000 (Direct Cost: ¥24,200,000、Indirect Cost: ¥7,260,000)
Fiscal Year 2018: ¥51,480,000 (Direct Cost: ¥39,600,000、Indirect Cost: ¥11,880,000)
Fiscal Year 2017: ¥65,520,000 (Direct Cost: ¥50,400,000、Indirect Cost: ¥15,120,000)
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| Outline of Final Research Achievements |
Amino-group carrier protein (AmCP) is a newly found protein that carries (a) substrate(s) bound to its C-terminus via an amino group to enzymes in the primary and secondary metabolite biosynthesis. In this project, we tried to determine the three-dimensional structures of biosynthetic enzymes involved in secondary metabolite biosynthesis in Actinomycetes to elucidate the mechanism for the AmCP recognition and expansion of the structural diversity of natural compounds via the AmCP system. Through this project, we discovered and elucidated several new and unique mechanisms.
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