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Life science basis of short-lived reactive species originated from foods

Research Project

Project/Area Number 17H06170
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

UCHIDA Koji  東京大学, 大学院農学生命科学研究科(農学部), 教授 (40203533)

Co-Investigator(Kenkyū-buntansha) 赤池 孝章  東北大学, 医学系研究科, 教授 (20231798)
上原 孝  岡山大学, 医歯薬学域, 教授 (00261321)
安達 貴弘  東京医科歯科大学, 難治疾患研究所, ジョイントリサーチ部門准教授 (50222625)
Project Period (FY) 2017-05-31 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥204,230,000 (Direct Cost: ¥157,100,000、Indirect Cost: ¥47,130,000)
Fiscal Year 2021: ¥37,830,000 (Direct Cost: ¥29,100,000、Indirect Cost: ¥8,730,000)
Fiscal Year 2020: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2019: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2018: ¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2017: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Keywords短寿命分子種 / 抗酸化剤 / 硫黄生物学 / 活性窒素種 / 活性酸素種 / タンパク質修飾 / 自然免疫 / 短寿命活性種 / ポリスルフィド / タンパク質フォールディング
Outline of Final Research Achievements

In this study, we focused on "short-lived molecular species" originating from plant-based food ingredients and aimed at discovering new molecular species and developing their functionality. We obtained a number of new findings, such as conversion of proteins into innate immune ligands that exhibit cross-reactivity with natural antibodies by unstable antioxidant metabolic intermediates, generation of new reactive sulfur species derived from sulfur-containing compounds in vivo, and a new protein function control mechanism by reactive nitrogen species.

Academic Significance and Societal Importance of the Research Achievements

毎日のように摂取する「食」は生体恒常性の中心に位置し、生命への影響は絶大である。本研究における、短寿命分子種による生体成分修飾の新たな機能性獲得に関する研究成果は、食の本質的機能の解明に関する研究の新しい方向性を示すとともに、食習慣を含めた次世代におけるライフスタイル変革につながる。

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(11 results)
  • 2023 Research Progress Assessment (Verification Result) ( PDF )
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (240 results)

All 2023 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (92 results) (of which Int'l Joint Research: 41 results,  Peer Reviewed: 81 results,  Open Access: 76 results) Presentation (130 results) (of which Int'l Joint Research: 25 results,  Invited: 54 results) Book (13 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Columbia University/Sonoma State University/University of Vermont(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Aston Universuty/University of Southampton/King's College London(英国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] University of Liege(ベルギー)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] National Institute of Oncology(ハンガリー)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis2023

    • Author(s)
      Okuda, K. et al.,
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 621-621

    • DOI

      10.1038/s41467-023-36232-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression2022

    • Author(s)
      Nishiyama Kazuhiro、Nishimura Akiyuki、Shimoda Kakeru、Tanaka Tomohiro、Kato Yuri、Shibata Takahiro、Tanaka Hiroshi、Kurose Hitoshi、Azuma Yasu-Taka、Ihara Hideshi、Kumagai Yoshito、Akaike Takaaki、Eaton Philip、Uchida Koji、Nishida Motohiro
    • Journal Title

      Science Signaling

      Volume: 15 Issue: 716 Pages: 716-716

    • DOI

      10.1126/scisignal.abj0644

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unique B-1 cells specific for both N-pyrrolated proteins and DNA evolve with apolipoprotein E deficiency.2022

    • Author(s)
      Lim SY, Yamaguchi K, Itakura M, Chikazawa M, Matsuda T, Uchida K.
    • Journal Title

      J Biol Chem

      Volume: 298 Issue: 2 Pages: 101582-101582

    • DOI

      10.1016/j.jbc.2022.101582

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone functions as a cell-surface receptor for AGEs2022

    • Author(s)
      Itakura Masanori、Yamaguchi Kosuke、Kitazawa Roma、Lim Sei-Young、Anan Yusuke、Yoshitake Jun、Shibata Takahiro、Negishi Lumi、Sugawa Hikari、Nagai Ryoji、Uchida Koji
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 2974-2986

    • DOI

      10.1038/s41467-022-30626-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid Isolation of Extracellular Vesicles Using a Hydrophilic Porous Silica Gel-Based Size-Exclusion Chromatography Column2022

    • Author(s)
      Yoshitake Jun、Azami Mayuko、Sei Haruka、Onoshima Daisuke、Takahashi Kumiko、Hirayama Akiyoshi、Uchida Koji、Baba Yoshinobu、Shibata Takahiro
    • Journal Title

      Analytical Chemistry

      Volume: 94 Issue: 40 Pages: 13676-13681

    • DOI

      10.1021/acs.analchem.2c01053

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Natural polyphenols convert proteins into histone-binding ligands2022

    • Author(s)
      Yamaguchi Kosuke、Itakura Masanori、Tsukamoto Mona、Lim Sei-Young、Uchida Koji
    • Journal Title

      Journal of Biological Chemistry

      Volume: 298 Issue: 11 Pages: 102529-102529

    • DOI

      10.1016/j.jbc.2022.102529

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative Determination of 2-Oxo-Imidazole-Containing Dipeptides by High-Performance Liquid Chromatography/Tandem Mass Spectrometry2022

    • Author(s)
      Komae Somei、Kasamatsu Shingo、Uchida Koji、Ihara Hideshi
    • Journal Title

      Antioxidants

      Volume: 11 Issue: 12 Pages: 2401-2401

    • DOI

      10.3390/antiox11122401

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conversion of proteins into DNA mimetics by lipid peroxidation2022

    • Author(s)
      Uchida Koji
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 728 Pages: 109374-109374

    • DOI

      10.1016/j.abb.2022.109374

    • Related Report
      2021 Annual Research Report
    • Open Access
  • [Journal Article] タンパク質最終糖化産物(AGEs)の抗炎症機能2022

    • Author(s)
      板倉正典,内田浩二
    • Volume
      40
    • Pages
      2637
    • DOI

      10.18958/7133-00003-0000240-00

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection.2022

    • Author(s)
      Tsutsuki Hiroyasu, Zhang Tianli, Yahiro Kinnosuke, Ono Katsuhiko, Fujiwara Yukio, Iyoda Sunao, Wei Fan-Yan, Monde Kazuaki, Seto Kazuko, Ohnishi Makoto, Oshiumi Hiroyuki, Akaike Takaaki, Sawa Tomohiro.
    • Journal Title

      iScience

      Volume: 25 Issue: 4 Pages: 104050-104050

    • DOI

      10.1016/j.isci.2022.104050

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of nitric oxide/reactive oxygen species redox signaling by nNOS splicing variants.2022

    • Author(s)
      Kasamatsu Shingo, Tsutsuki Hiroyasu, Ida Tomoaki, Sawa Tomohiro, Watanabe Yasuo, Akaike Takaaki, Ihara Hideshi.
    • Journal Title

      Nitric Oxide

      Volume: 120 Pages: 44-52

    • DOI

      10.1016/j.niox.2022.01.004

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] What triggers inflammation in COVID-19?2022

    • Author(s)
      Sawa Tomohiro, Akaike Takaaki.
    • Journal Title

      eLife

      Volume: 11

    • DOI

      10.7554/elife.76231

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation.2022

    • Author(s)
      Kurane, T., Matsunaga, T., Ida, T., Sawada, K., Nishimura, A., Fukui, M., Umemura, M., Nakayama, M., Ohara, N., Matsumoto, S., Akaike, T., Matsuzaki, G., Takaesu, G.
    • Journal Title

      FASEB Journal

      Volume: 36 Issue: 1

    • DOI

      10.1096/fj.202101074rr

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical biology of reactive sulfur species: Hydrolysis-driven equilibrium of polysulfides as a determinant of physiological functions.2022

    • Author(s)
      Sawa Tomohiro, Takata Tsuyoshi, Matsunaga Tetsuro, Ihara Hideshi, Motohashi Hozumi, Akaike Takaaki.
    • Journal Title

      Antioxidants & Redox Signaling

      Volume: 36 Issue: 4-6 Pages: 327-336

    • DOI

      10.1089/ars.2021.0170

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recognition of acrolein-specific epitopes by B cell receptors triggers an innate immune response2021

    • Author(s)
      Endo Ryunosuke、Uchiyama Kazuki、Lim Sei-Young、Itakura Masanori、Adachi Takahiro、Uchida Koji
    • Journal Title

      Journal of Biological Chemistry

      Volume: 296 Pages: 100648-100648

    • DOI

      10.1016/j.jbc.2021.100648

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis2021

    • Author(s)
      Sredoja Tisma Vesna、Bulimbasic Stela、Galesic Ljubanovic Danica、Galesic Kresimir、Morovic-Vergles Jadranka、Mitrovic Josko、Uchida Koji、Tatzber Franz、Zarkovic Neven、Jaganjac Morana
    • Journal Title

      Molecules

      Volume: 26 Issue: 8 Pages: 2344-2344

    • DOI

      10.3390/molecules26082344

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxidative deamination of lysine residues by polyphenols generates an equilibrium of aldehyde and 2-piperidinol products2021

    • Author(s)
      Yamaguchi K, Itakura M, Kitazawa R, Lim SY, Nagata K, Shibata T, Akagawa M, Uchida K.
    • Journal Title

      J Biol Chem

      Volume: 297 Issue: 3 Pages: 101035-101035

    • DOI

      10.1016/j.jbc.2021.101035

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distribution and quantitative analysis of homoanserine and its 2-oxo derivative in mouse tissues2021

    • Author(s)
      Kakihana Yuki、Kasamatsu Shingo、Uchida Koji、Ihara Hideshi
    • Journal Title

      Free Radical Research

      Volume: 55 Issue: 6 Pages: 579-588

    • DOI

      10.1080/10715762.2021.1888945

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified2021

    • Author(s)
      Tanaka Hiromasa、Hosoi Yugo、Ishikawa Kenji、Yoshitake Jun、Shibata Takahiro、Uchida Koji、Hashizume Hiroshi、Mizuno Masaaki、Okazaki Yasumasa、Toyokuni Shinya、Nakamura Kae、Kajiyama Hiroaki、Kikkawa Fumitaka、Hori Masaru
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-021-98020-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low-molecular-weight whey proteins promote collagen production in dermal fibroblasts via the TGF-β receptor/Smad pathway2021

    • Author(s)
      Katayoshi Takeshi、Kusano Yuri、Shibata Takahiro、Uchida Koji、Tsuji-Naito Kentaro
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 11 Pages: 2232-2240

    • DOI

      10.1093/bbb/zbab155

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 2-Oxo-Imidazole-Containing Dipeptides Play a Key Role in the Antioxidant Capacity of Imidazole-Containing Dipeptides2021

    • Author(s)
      Kasamatsu Shingo、Komae Somei、Matsukura Kana、Kakihana Yuki、Uchida Koji、Ihara Hideshi
    • Journal Title

      Antioxidants

      Volume: 10 Issue: 9 Pages: 1434-1434

    • DOI

      10.3390/antiox10091434

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation.2021

    • Author(s)
      Erdelyi Katalin, Ditroi Tamas, Johansson Henrik J., Czikora Agnes, Balog Noemi, Silwal-Pandit Laxmi, Ida Tomoaki, Olasz Judit, Hajdu Dorottya, Matrai Zoltan, Csuka Orsolya, Uchida Koji, Tovari Jozsef, Engebraten Olav, Akaike Takaaki, Borresen Dale Anne-Lise, Kasler Miklos, Lehtio Janne, Nagy Peter.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 118 Issue: 45

    • DOI

      10.1073/pnas.2100050118

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Special issue on “recent topics of redox chemistry and biology”2021

    • Author(s)
      Niki Etsuo、Uchida Koji
    • Journal Title

      Free Radical Research

      Volume: 55 Issue: 4 Pages: 305-306

    • DOI

      10.1080/10715762.2021.1974786

    • Related Report
      2021 Annual Research Report
    • Open Access
  • [Journal Article] Virucidal effect of monogalactosyl diacylglyceride from a green microalga, Coccomyxa sp. KJ, against clinical isolates of SARS-CoV-2 as assessed by a plaque assay.2021

    • Author(s)
      Hayashi Kyoko, Asai Satomi, Umezawa Kazuo, Kakizoe Hidehumi, Miyachi Hayato, Morita Masanobu, Akaike Takaaki, Kuno Hitoshi, Komatsu Satoko, Watanabe Takumi, Kawahara Toshio.
    • Journal Title

      Journal of Clinical Laboratory Analysis

      Volume: 36 Issue: 1

    • DOI

      10.1002/jcla.24146

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Methods in sulfide and persulfide research.2021

    • Author(s)
      Takata Tsuyoshi, Jung Minkyung, Matsunaga Tetsuro, Ida Tomoaki, Morita Masanobu, Motohashi Hozumi, Shen Xinggui, Kevil Christopher G., Fukuto Jon M., Akaike Takaaki.
    • Journal Title

      Nitric Oxide

      Volume: 116 Pages: 47-64

    • DOI

      10.1016/j.niox.2021.09.002

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sulfide catabolism ameliorates hypoxic brain injury.2021

    • Author(s)
      Marutani E, Morita M, Hirai S, Kai S, Grange RMH, Miyazaki Y, Nagashima F, Traeger L, Magliocca A, Ida T, Matsunaga T, Batten A, Li R, Tanaka T, Ikeda T, Nakagawa A, Atochin DN, Ihara H, Olenchock BA, Shen X, Nishida M, Hanaoka K, Kevil CG, Xian M, Bloch DB, Akaike T, Hindle AG, Motohashi H, Ichinose F, et al.
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 3108-3108

    • DOI

      10.1038/s41467-021-23363-x

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cysteine hydropersulfide inactivates β-lactam antibiotics to form ring opened carbothioic S-acids in bacteria.2021

    • Author(s)
      Ono, K., Kitamura, Y., Zhang, T., Tsutsuki, H., Rahman, A., Akaike, T., Ihara, T., Sawa, T.
    • Journal Title

      ACS Chem Biol.

      Volume: 16 Issue: 4 Pages: 731-739

    • DOI

      10.1021/acschembio.1c00027

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comment on “Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity”.2021

    • Author(s)
      Doka Eva, Arner Elias SJ, Schmidt Edward E, Dick Tobias P, Vliet Albert van der, Yang Jing, Szatmari Reka, Ditroi Tamas, Wallace John L, Cirino Giuseppe , Olson Kenneth, Motohashi Hozumi, Fukuto Jon M, Pluth Michael D, Feelisch Martin, Akaike Takaaki, Wink David A, Ignarro Louis J, Nagy Peter.
    • Journal Title

      Science Advances

      Volume: 7 Issue: 17

    • DOI

      10.1126/sciadv.abe7006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation.2021

    • Author(s)
      Zhang, T., Tsutsuki, H., Islam, W., Ono, K., Takeda, K., Akaike, T. and Sawa, T.
    • Journal Title

      Redox Biology

      Volume: 41 Pages: 101930-101930

    • DOI

      10.1016/j.redox.2021.101930

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity2021

    • Author(s)
      Honda Kazufumi、Hishiki Takako、Yamamoto Sohe、Naito Yoshiko、Matsuura Tomomi、Iwaisako Keiko、Masui Toshihiko、Sakuma Tomohiro、Matsubara Osamu、Huang Wilber、Ida Tomoaki、Akaike Takaaki、Masugi Yohei、Sakamoto Michiie、Kato Tomoyasu、Kabe Yasuaki、Suematsu Makoto
    • Journal Title

      Redox Biology

      Volume: 41 Pages: 101926-101926

    • DOI

      10.1016/j.redox.2021.101926

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Loss of cell wall integrity genes cpxA and mrcB causes flocculation in Escherichia coli2021

    • Author(s)
      Sugawara Keita、Toyoda Hayato、Kimura Mami、Hayasaka Shunsuke、Saito Hiromi、Kobayashi Hiroshi、Ihara Kunio、Ida Tomoaki、Akaike Takaaki、Ando Eiji、Hyodo Mamoru、Hayakawa Yoshihiro、Hamamoto Shin、Uozumi Nobuyuki
    • Journal Title

      Biochemical Journal

      Volume: 478 Issue: 1 Pages: 41-59

    • DOI

      10.1042/bcj20200723

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High-Precision Sulfur Metabolomics Innovated by a New Specific Probe for Trapping Reactive Sulfur Species2021

    • Author(s)
      Kasamatsu Shingo、Ida Tomoaki、Koga Taisei、Asada Kosho、Motohashi Hozumi、Ihara Hideshi、Akaike Takaaki
    • Journal Title

      Antioxidants & Redox Signaling

      Volume: in press Issue: 18 Pages: 1407-1419

    • DOI

      10.1089/ars.2020.8073

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antioxidative and anti-inflammatory actions of reactive cysteine persulfides2021

    • Author(s)
      T. Zhang, H. Tsutsuki, K. Ono, T. Akaike, T. Sawa
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 68 Issue: 1 Pages: 5-8

    • DOI

      10.3164/jcbn.20-13

    • NAID

      130007965274

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism2020

    • Author(s)
      Petkovic Igor、Bresgen Nikolaus、Gilardoni Ettore、Regazzoni Luca、Uchida Koji、Aldini Giancarlo、Siems Werner、Eckl Peter
    • Journal Title

      Antioxidants

      Volume: 9 Issue: 2 Pages: 150-150

    • DOI

      10.3390/antiox9020150

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transferrin Receptor Is a Specific Ferroptosis Marker2020

    • Author(s)
      Feng Huizhong、Schorpp Kenji、Jin Jenny、Yozwiak Carrie E.、Hoffstrom Benjamin G.、Decker Aubrianna M.、Rajbhandari Presha、Stokes Michael E.、Bender Hannah G.、Csuka Joleen M.、Upadhyayula Pavan S.、Canoll Peter、Uchida Koji、Soni Rajesh K.、Hadian Kamyar、Stockwell Brent R.
    • Journal Title

      Cell Reports

      Volume: 30 Issue: 10 Pages: 3411-3423.e7

    • DOI

      10.1016/j.celrep.2020.02.049

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Quantitative analysis of oxidized vitamin B1 metabolites generated by hypochlorous acid2020

    • Author(s)
      Sasatsuki Hitoshi、Nakazaki Atsuo、Uchida Koji、Shibata Takahiro
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 152 Pages: 197-206

    • DOI

      10.1016/j.freeradbiomed.2020.03.010

    • NAID

      120006894738

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycolaldehyde is an endogenous source of lysine N-pyrrolation2020

    • Author(s)
      Chikazawa Miho、Yoshitake Jun、Lim Sei-Young、Iwata Shiori、Negishi Lumi、Shibata Takahiro、Uchida Koji
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 22 Pages: 7697-7709

    • DOI

      10.1074/jbc.ra120.013179

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through <i>S</i>-oxidation of protein tyrosine phosphatase 1B2020

    • Author(s)
      Luong Nho Cong、Abiko Yumi、Shibata Takahiro、Uchida Koji、Warabi Eiji、Suzuki Midori、Noguchi Takuya、Matsuzawa Atsushi、Kumagai Yoshito
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 45 Issue: 6 Pages: 349-363

    • DOI

      10.2131/jts.45.349

    • NAID

      130007851869

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D2020

    • Author(s)
      Takamiya Rina、Takahashi Motoko、Maeno Toshitaka、Saito Atsushi、Kato Masaki、Shibata Takahiro、Uchida Koji、Ariki Shigeru、Nakano Miyako
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1864 Issue: 11 Pages: 129699-129699

    • DOI

      10.1016/j.bbagen.2020.129699

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor2020

    • Author(s)
      Hasegawa Kana、Kuwata Keiko、Yoshitake Jun、Shimomura Sayako、Uchida Koji、Shibata Takahiro
    • Journal Title

      The FEBS Journal

      Volume: 288 Issue: 6 Pages: 1906-1917

    • DOI

      10.1111/febs.15557

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates2020

    • Author(s)
      Kamata Shotaro、Oyama Takuji、Saito Kenta、Honda Akihiro、Yamamoto Yume、Suda Keisuke、Ishikawa Ryo、Itoh Toshimasa、Watanabe Yasuo、Shibata Takahiro、Uchida Koji、Suematsu Makoto、Ishii Isao
    • Journal Title

      iScience

      Volume: 23 Issue: 11 Pages: 101727-101727

    • DOI

      10.1016/j.isci.2020.101727

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measuring Reactive Sulfur Species and Thiol Oxidation States: Challenges and Cautions in Relation to Alkylation-Based Protocols2020

    • Author(s)
      Nagy Peter、Doka Eva、Ida Tomoaki、Akaike Takaaki
    • Journal Title

      Antioxidants & Redox Signaling

      Volume: 33 Issue: 16 Pages: 1174-1189

    • DOI

      10.1089/ars.2020.8077

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells2020

    • Author(s)
      Tawarayama Hiroshi、Suzuki Noriyuki、Inoue-Yanagimachi Maki、Himori Noriko、Tsuda Satoru、Sato Kota、Ida Tomoaki、Akaike Takaaki、Kunikata Hiroshi、Nakazawa Toru
    • Journal Title

      Ocular Immunology and Inflammation

      Volume: in press Issue: 4 Pages: 1-12

    • DOI

      10.1080/09273948.2020.1833224

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides2020

    • Author(s)
      Sawa Tomohiro、Motohashi Hozumi、Ihara Hideshi、Akaike Takaaki
    • Journal Title

      Biomolecules

      Volume: 10 Issue: 9 Pages: 1245-1245

    • DOI

      10.3390/biom10091245

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Nitro-cGMP modulates exocytosis in adrenal chromaffin cells2020

    • Author(s)
      Tsutsuki Hiroyasu、Kasamatsu Shingo、Kunieda Kohei、Ida Tomoaki、Sawa Tomohiro、Sasakawa Nobuyuki、Akaike Takaaki、Ihara Hideshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: in press Issue: 1 Pages: 225-230

    • DOI

      10.1016/j.bbrc.2020.03.045

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein2020

    • Author(s)
      Fujikawa Kana、Nakahara Kengo、Takasugi Nobumasa、Nishiya Tadashi、Ito Akihiro、Uchida Koji、Uehara Takashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 524 Issue: 4 Pages: 910-915

    • DOI

      10.1016/j.bbrc.2020.02.011

    • NAID

      120006956819

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Control of Protein Function Through Oxidation and Reduction of Persulfidated States2020

    • Author(s)
      E Doka, T Ida, M Dagnell, Y Abiko, N C Luong, N Balog, T Takata, B Espinosa, A Nishimura, Q Cheng, Y Funato, H Miki, J M Fukuto, J R Prigge, E E Schmidt, E S J Arner, Y Kumagai, T Akaike, P Nagy
    • Journal Title

      Sci Adv

      Volume: 6 Issue: 1 Pages: 8358-8358

    • DOI

      10.1126/sciadv.aax8358

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation of food-derived bacteria inducing interleukin-22 in B cells2020

    • Author(s)
      KUMAZAWA Toshihiko、KOTAKE Kunihiko、NISHIMURA Atsuhisa、ASAI Noriyuki、UGAJIN Tsukasa、YOKOZEKI Hiroo、ADACHI Takahiro
    • Journal Title

      Bioscience of Microbiota, Food and Health

      Volume: 39 Issue: 1 Pages: 1-9

    • DOI

      10.12938/bmfh.19-012

    • NAID

      130007788974

    • ISSN
      2186-3342
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent advance in reactive sulfur research2019

    • Author(s)
      居原 秀、本橋 ほづみ、赤池 孝章
    • Journal Title

      生化学

      Volume: 91 Issue: 3 Pages: 388-398

    • DOI

      10.14952/SEIKAGAKU.2019.910388

    • NAID

      40021956227

    • ISSN
      0037-1017
    • Year and Date
      2019-06-25
    • Related Report
      2019 Annual Research Report
  • [Journal Article] 2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct2019

    • Author(s)
      Yoshitake Jun、Shibata Takahiro、Shimayama Chihiro、Uchida Koji
    • Journal Title

      Redox Biology

      Volume: 23 Pages: 101115-101115

    • DOI

      10.1016/j.redox.2019.101115

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia2019

    • Author(s)
      Guerby Paul、Swiader Audrey、Aug? Nathalie、Parant Olivier、Vayssi?re Christophe、Uchida Koji、Salvayre Robert、Negre-Salvayre Anne
    • Journal Title

      Redox Biology

      Volume: 22 Pages: 101126-101126

    • DOI

      10.1016/j.redox.2019.101126

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model2019

    • Author(s)
      Zhang Yan、Tan Hui、Daniels Jacob D.、Zandkarimi Fereshteh、Liu Hengrui、Brown Lewis M.、Uchida Koji、O'Connor Owen A.、Stockwell Brent R.
    • Journal Title

      Cell Chemical Biology

      Volume: 26 Issue: 5 Pages: 623-633.e9

    • DOI

      10.1016/j.chembiol.2019.01.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins.2019

    • Author(s)
      Hirose S, Hioki Y, Miyashita H, Hirade N, Yoshitake J, Shibata T, Kikuchi R, Matsushita T, Chikazawa M, Itakura M, Zhang M, Nagata K, Uchida K.
    • Journal Title

      J Biol Chem.

      Volume: 294(28) Issue: 28 Pages: 11035-11045

    • DOI

      10.1074/jbc.ra118.006629

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap12019

    • Author(s)
      Suzuki Takafumi、Muramatsu Aki、Saito Ryota、Iso Tatsuro、Shibata Takahiro、Kuwata Keiko、Kawaguchi Shin-ichi、Iwawaki Takao、Adachi Saki、Suda Hiromi、Morita Masanobu、Uchida Koji、Baird Liam、Yamamoto Masayuki
    • Journal Title

      Cell Reports

      Volume: 28 Issue: 3 Pages: 746-758

    • DOI

      10.1016/j.celrep.2019.06.047

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal(ONE) in preeclamptic placentas2019

    • Author(s)
      Guerby Paul、Swiader Audrey、Tasta Oriane、Pont Frederic、Rodriguez Frederic、Parant Olivier、Vayssiere Christophe、Shibata Takahiro、Uchida Koji、Salvayre Robert、Negre-Salvayre Anne
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 141 Pages: 416-425

    • DOI

      10.1016/j.freeradbiomed.2019.07.015

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ibudilast attenuates doxorubicin‐induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes2019

    • Author(s)
      Nishiyama Kazuhiro、Numaga‐Tomita Takuro、Fujimoto Yasuyuki、Tanaka Tomohiro、Toyama Chiemi、Nishimura Akiyuki、Yamashita Tomohiro、Matsunaga Naoya、Koyanagi Satoru、Azuma Yasu‐Taka、Ibuki Yuko、Uchida Koji、Ohdo Shigehiro、Nishida Motohiro
    • Journal Title

      British Journal of Pharmacology

      Volume: 176 Issue: 18 Pages: 3723-3738

    • DOI

      10.1111/bph.14777

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein adductomics: A comprehensive analysis of protein modifications by electrophiles2019

    • Author(s)
      Shibata Takahiro、Uchida Koji
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 144 Pages: 218-222

    • DOI

      10.1016/j.freeradbiomed.2019.02.034

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] A unique mechanism for thiolation of serum albumins by disulphide molecules2019

    • Author(s)
      Nakashima Fumie、Shibata Takahiro、Uchida Koji
    • Journal Title

      The Journal of Biochemistry

      Volume: 167 Pages: 165-171

    • DOI

      10.1093/jb/mvz084

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling2019

    • Author(s)
      Feelisch Martin、Akaike Takaaki、Griffiths Kayleigh、Ida Tomoaki、Prysyazhna Oleksandra、Goodwin Joanna J、Gollop Nicholas D、Fernandez Bernadette O、Minnion Magdalena、Cortese-Krott Miriam M、Borgognone Alessandra、Hayes Rosie M、Eaton Philip、Frenneaux Michael P、Madhani Melanie
    • Journal Title

      Cardiovascular Research

      Volume: 116 Issue: 1 Pages: 51-62

    • DOI

      10.1093/cvr/cvz202

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] AUTACs: Cargo-Specific Degraders Using Selective Autophagy2019

    • Author(s)
      Takahashi Daiki、Moriyama Jun、Nakamura Tomoe、Miki Erika、Takahashi Eriko、Sato Ayami、Akaike Takaaki、Itto-Nakama Kaori、Arimoto Hirokazu
    • Journal Title

      Molecular Cell

      Volume: 76 Issue: 5 Pages: 797-810.e10

    • DOI

      10.1016/j.molcel.2019.09.009

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rational Design of a Dual-Reactivity-Based Fluorescent Probe for Visualizing Intracellular HSNO.2019

    • Author(s)
      Chen W, Matsunaga T, Neill DL, Yang CT, Akaike T, Xian M.
    • Journal Title

      Angew Chem

      Volume: 58 Issue: 45 Pages: 16067-16070

    • DOI

      10.1002/anie.201908950

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Data‐Driven Identification of Hydrogen Sulfide Scavengers2019

    • Author(s)
      Yang Chun‐tao、Wang Yingying、Marutani Eizo、Ida Tomoaki、Ni Xiang、Xu Shi、Chen Wei、Zhang Hui、Akaike Takaaki、Ichinose Fumito、Xian Ming
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 58 Issue: 32 Pages: 10898-10902

    • DOI

      10.1002/anie.201905580

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nitrosative stress in patients with asthma?chronic obstructive pulmonary disease overlap2019

    • Author(s)
      Kyogoku Yorihiko、Sugiura Hisatoshi、Ichikawa Tomohiro、Numakura Tadahisa、Koarai Akira、Yamada Mitsuhiro、Fujino Naoya、Tojo Yutaka、Onodera Katsuhiro、Tanaka Rie、Sato Kei、Sano Hirohito、Yamanaka Shun、Itakura Koji、Mitsune Ayumi、Tamada Tsutomu、Akaike Takaaki、Ichinose Masakazu
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 144 Issue: 4 Pages: 972-983

    • DOI

      10.1016/j.jaci.2019.04.023

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension2019

    • Author(s)
      Rudyk Olena、Rowan Alice、Prysyazhna Oleksandra、Krasemann Susanne、Hartmann Kristin、Zhang Min、Shah Ajay M.、Ruppert Clemens、Weiss Astrid、Schermuly Ralph T.、Ida Tomoaki、Akaike Takaaki、Zhao Lan、Eaton Philip
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Issue: 26 Pages: 13016-13025

    • DOI

      10.1073/pnas.1904064116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock2019

    • Author(s)
      Zhang Tianli、Ono Katsuhiko、Tsutsuki Hiroyasu、Ihara Hideshi、Islam Waliul、Akaike Takaaki、Sawa Tomohiro
    • Journal Title

      Cell Chemical Biology

      Volume: in press Issue: 5 Pages: 686-698.e4

    • DOI

      10.1016/j.chembiol.2019.02.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.2019

    • Author(s)
      Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.
    • Journal Title

      Redox Biol

      Volume: 21 Pages: 101096-101096

    • DOI

      10.1016/j.redox.2019.101096

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Emerging role of electrophiles as a key regulator for endoplasmic reticulum (ER) stress.2019

    • Author(s)
      Takasugi, N., Hiraoka, H., Nakahara, K., Akiyama, S., Fujikawa, K., Nomura, R., Furuichi, M., and Uehara, T.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 20(7) Issue: 7 Pages: 1783-1783

    • DOI

      10.3390/ijms20071783

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corticotropin-releasing hormone is significantly upregulated in the mouse paraventricular nucleus following a single oral dose of cinnamtannin A2 as an (−)-epicatechin tetramer2019

    • Author(s)
      Fujii Yasuyuki、Suzuki Kenta、Adachi Takahiro、Taira Shu、Osakabe Naomi
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 65 Issue: 1 Pages: 29-33

    • DOI

      10.3164/jcbn.19-19

    • NAID

      130007672103

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Propolis induces Ca<sup>2+</sup> signaling in immune cells2019

    • Author(s)
      Adachi T, Yoshikawa S, Tezuka H, Tsuji NM, Ohteki T, Karasuyama H, Kumazawa T.
    • Journal Title

      Bioscience of Microbiota, Food and Health

      Volume: 38 Issue: 4 Pages: 141-149

    • DOI

      10.12938/bmfh.19-011

    • NAID

      130007738832

    • ISSN
      2186-3342
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Current topics in prostaglandin D2 metabolites2018

    • Author(s)
      柴田 貴広、内田 浩二
    • Journal Title

      生化学

      Volume: 90 Issue: 5 Pages: 711-714

    • DOI

      10.14952/SEIKAGAKU.2018.900711

    • ISSN
      0037-1017
    • Year and Date
      2018-10-25
    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] 増大特集 タンパク質・核酸の分子修飾 Ⅱ.細胞質/オルガネラでの分子修飾 酸化還元状態 S-ニトロシル化2018

    • Author(s)
      平岡 秀樹、上原 孝
    • Journal Title

      生体の科学

      Volume: 69 Issue: 5 Pages: 444-445

    • DOI

      10.11477/mf.2425200870

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2018-10-15
    • Related Report
      2018 Annual Research Report
  • [Journal Article] 2-Oxo-histidine-containing dipeptides are functional oxidation products2018

    • Author(s)
      Ihara Hideshi、Kakihana Yuki、Yamakage Akane、Kai Kenji、Shibata Takahiro、Nishida Motohiro、Yamada Ken-ichi、Uchida Koji
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 4 Pages: 1279-1289

    • DOI

      10.1074/jbc.ra118.006111

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a novel monoclonal antibody against 4-hydroxy-2E,6Z-dodecadienal (4-HDDE)-protein adducts: Immunochemical application in quantitative and qualitative analyses of lipid peroxidation in vitro and ex vivo2018

    • Author(s)
      Uchida Koji、Shibata Takahiro、Toyokuni Shinya、Daniel Bareket、Zarkovic Kamelija、Zarkovic Neven、Sasson Shlomo
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 124 Pages: 12-20

    • DOI

      10.1016/j.freeradbiomed.2018.05.079

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration2018

    • Author(s)
      Pujol-Lereis Luciana M.、Liebisch Gerhard、Schick Tina、Lin Yuchen、Grassmann Felix、Uchida Koji、Zipfel Peter F.、Fauser Sascha、Skerka Christine、Weber Bernhard H. F.
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 8 Pages: 0200739-0200739

    • DOI

      10.1371/journal.pone.0200739

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling2018

    • Author(s)
      Khan Shahzada、Fujii Shigemoto、Matsunaga Tetsuro、Nishimura Akira、Ono Katsuhiko、Ida Tomoaki、Ahmed Khandaker Ahtesham、Okamoto Tatsuya、Tsutsuki Hiroyasu、Sawa Tomohiro、Akaike Takaaki
    • Journal Title

      Cell Chemical Biology

      Volume: 25 Issue: 11 Pages: 1403-1413

    • DOI

      10.1016/j.chembiol.2018.08.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?2018

    • Author(s)
      Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdandi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A.
    • Journal Title

      Redox Biol.

      Volume: 14 Pages: 379-385

    • DOI

      10.1016/j.redox.2017.10.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] B cell activation in the cecal patches during the development of an experimental colitis model.2018

    • Author(s)
      Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 496 Issue: 2 Pages: 367-373

    • DOI

      10.1016/j.bbrc.2018.01.053

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice2018

    • Author(s)
      Nakagawa Yuta、Ishimura Kana、Oya Satomi、Kamino Masaki、Fujii Yasuyuki、Nanba Fumio、Toda Toshiya、Ishii Takeshi、Adachi Takahiro、Suhara Yoshitomo、Osakabe Naomi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: 0201203-0201203

    • DOI

      10.1371/journal.pone.0201203

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells2018

    • Author(s)
      Lino AC, Dang VD, Lampropoulou V, Welle A, Joedicke J, Pohar J, Simon Q, Thalmensi J, Tsubata T, Adachi T, Korniotis S, Goosmann C, Weill JC, Reynaud CA, Kaufmann SHE, Walter J, Fillatreau S.
    • Journal Title

      Immunity

      Volume: 49 Issue: 1 Pages: 120-133.e9

    • DOI

      10.1016/j.immuni.2018.06.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation of immune-regulatory Tetragenococcus halophilus from miso2018

    • Author(s)
      Kumazawa Toshihiko、Nishimura Atsuhisa、Asai Noriyuki、Adachi Takahiro
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 12 Pages: 0208821-0208821

    • DOI

      10.1371/journal.pone.0208821

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single oral administration of flavan 3-ols induces stress responses monitored with stress hormone elevations in the plasma and paraventricular nucleus2018

    • Author(s)
      Fujii Yasuyuki、Suzuki Kenta、Hasegawa Yahiro、Nanba Fumio、Toda Toshiya、Adachi Takahiro、Taira Shu、Osakabe Naomi
    • Journal Title

      Neuroscience Letters

      Volume: 682 Pages: 106-111

    • DOI

      10.1016/j.neulet.2018.06.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Nitro-cGMP attenuates the interaction between SNARE complex and complexin through S-guanylation of SNAP-252018

    • Author(s)
      Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H.
    • Journal Title

      ACS Chem Neurosci

      Volume: 9 Issue: 2 Pages: 217-223

    • DOI

      10.1021/acschemneuro.7b00363

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脂質異常症に関連したタンパク質のS-チオール化2018

    • Author(s)
      中島史恵、柴田貴広、内田浩二
    • Journal Title

      実験医学増刊 「レドックス疾患学」 (赤池孝章、本橋ほづみ、内田浩二、末松誠 編集) 羊土社

      Volume: 36 Pages: 264-270

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 活性イオウによる生体防御応答、エネルギー代謝と寿命制御2018

    • Author(s)
      澤 智裕、赤池孝章
    • Journal Title

      実験医学増刊 「レドックス疾患学」 (赤池孝章、本橋ほづみ、内田浩二、末松誠 編集) 羊土社

      Volume: 36 Pages: 649-655

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 硫黄呼吸の発見:ペルスルフィド産生酵素による新しいエネルギー代謝2018

    • Author(s)
      西村 明、赤池孝章
    • Journal Title

      現代化学

      Volume: 565 Pages: 55-59

    • NAID

      40021493631

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Adductome-based identification of biomarkers for lipid peroxidation.2017

    • Author(s)
      Shibata T, Shimizu K, Hirano K, Nakashima F, Kikuchi R, Matsushita T, Uchida K.
    • Journal Title

      J Biol Chem.

      Volume: 292(20) Issue: 20 Pages: 8223-8235

    • DOI

      10.1074/jbc.m116.762609

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes2017

    • Author(s)
      Luis PB, Gordon ON, Nakashima F, Joseph AI, Shibata T, Uchida K, Schneider C
    • Journal Title

      Biochemical Pharmacology

      Volume: 132 Pages: 143-149

    • DOI

      10.1016/j.bcp.2017.03.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes2017

    • Author(s)
      Gimenez-Bastida JA, Shibata T, Uchida K, Schneider C.
    • Journal Title

      FASEB J.

      Volume: 31 Issue: 5 Pages: 1867-1878

    • DOI

      10.1096/fj.201601136r

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke2017

    • Author(s)
      Takamiya Rina、Uchida Koji、Shibata Takahiro、Maeno Toshitaka、Kato Masaki、Yamaguchi Yoshiki、Ariki Shigeru、Hasegawa Yoshihiro、Saito Atsushi、Miwa Soichi、Takahashi Hiroki、Akaike Takaaki、Kuroki Yoshio、Takahashi Motoko
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 8304-8304

    • DOI

      10.1038/s41598-017-08588-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of polyphenol-specific innate epitopes originated from a resveratrol analogue.2017

    • Author(s)
      Furuhashi, M., Hatasa, Y., Kawamura, S., Shibata, T., Akagawa, M., Uchida, K.
    • Journal Title

      Biochemistry

      Volume: 56 Issue: 35 Pages: 470-4712

    • DOI

      10.1021/acs.biochem.7b00409

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lipid radicals cause light-induced retinal degeneration.2017

    • Author(s)
      Enoki M, Shinto S, Matsuoka Y, Otsuka A, Kaidzu S, Tanito M, Shibata T, Uchida K, Ohira A, Yamato M, Yamada KI.
    • Journal Title

      Chem Commun.

      Volume: 53 Issue: 79 Pages: 10922-10925

    • DOI

      10.1039/c7cc03387g

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics2017

    • Author(s)
      Akaike Takaaki、、、Nishida Motohiro(4)、、、、、、Fujii Shigemoto(20)、、、Motohashi Hozumi(26)
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1177-1177

    • DOI

      10.1038/s41467-017-01311-y

    • NAID

      120007134656

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 酸化脂質修飾タンパク質に対するアレルギー応答解析2023

    • Author(s)
      中村亘希、山口公輔、板倉正典、内田浩二
    • Organizer
      日本農芸化学会2023年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 短鎖脂肪酸によるタンパク質修飾を介した腸管免疫調節機構の解明2023

    • Author(s)
      不破未貴、山口公輔、千代田直人、板倉正典、内田浩二
    • Organizer
      日本農芸化学会2023年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 酸化型ビタミンC由来AGEsの核移行と核内ヒストンへの結合2023

    • Author(s)
      板倉正典、内田浩二
    • Organizer
      日本農芸化学会2023年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ファージディスプレイ法を用いた自己免疫疾患における抗好中球抗体の解析2023

    • Author(s)
      塚本萌南、阿南優佑、板倉正典、内田浩二
    • Organizer
      日本農芸化学会2023年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 内在性ピロール化タンパク質の同定2023

    • Author(s)
      山口公輔、板倉正典、内田浩二
    • Organizer
      日本農芸化学会2023年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 2-オキソヒスチジンの発見2022

    • Author(s)
      内田浩二
    • Organizer
      第76回日本栄養・食糧学会大会シンポジウム「イミダゾールペプチド研究の新展開」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 自然免疫に関与する酸化特異的エピトープ2022

    • Author(s)
      内田浩二
    • Organizer
      第64回日本脂質生化学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] タンパク質修飾を介した食の免疫記憶2022

    • Author(s)
      内田浩二
    • Organizer
      第49回日本毒性学会学術年会 ワークショップ「エクスポソームの新戦略」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Antioxidant assembly as a ligand for innate proteins2022

    • Author(s)
      Koji Uchida
    • Organizer
      第10回フリーラジカル学会アジア大会(SFRR Asia 2022)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞内ピロール化タンパク質の同定2022

    • Author(s)
      山口公輔、板倉正典、内田浩二
    • Organizer
      第95回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] IgE抗体を介したアクロレイン修飾タンパク質に対するアレルギー応答2022

    • Author(s)
      中村亘希、板倉正典、山口公輔、内田浩二
    • Organizer
      第95回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 自己免疫疾患における二重交差性自己抗体の解析2022

    • Author(s)
      阿南優佑、板倉正典、 上田宏、 内田浩二
    • Organizer
      第95回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ApoE欠損マウスにおける抗ピロール化タンパク質抗体レパトアの同定2022

    • Author(s)
      林 世映, 近澤 未歩, 板倉 正典, 松田 知成, 内田 浩二
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ポリフェノールによるタンパク質修飾を介した自然免疫調節機構の解明2022

    • Author(s)
      山口 公輔, 畠山 千晴, 下宮 豪介, 林 世映, 板倉 正典, 内田 浩二
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 酸化型ビタミンC 由来AGEsによる炎症応答制御メカニズムの解明2022

    • Author(s)
      板倉 正典, 内田 浩二
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ポリフェノール修飾タンパク質の構造解析並びにヒストンとの相互作用メカニズムの解明2022

    • Author(s)
      山口 公輔, 板倉 正典, 北澤 麗磨, 林 世映, 永田 宏次, 柴田 貴広, 赤川 貢, 内田 浩二
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アスコルビン酸酸化に起因するタンパク質ピロール化2022

    • Author(s)
      吉武 淳, 柴田 貴広, 近澤 未歩, 内田 浩二
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ポリフェノール修飾タンパク質に対する高親和性ペプチドの解析2022

    • Author(s)
      山本 広史, 佐々木 栄太, 板倉 正典, 内田 浩二,
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ポリフェノールによるヒストン凝集メカニズムと病態生理学的意義の解明2022

    • Author(s)
      塚本 萌南, 山口 公輔, 板倉 正典, 内田 浩二
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] フェロトーシス誘導細胞における酸化特異的エピトープ形成と免疫応答解析2022

    • Author(s)
      糸井 海星, 林 世映, 三浦 由香子, 板倉 正典, 今井 浩孝, 内田 浩二,
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 抗体工学を利用した抗DNA自己抗体の解析2022

    • Author(s)
      阿南 優佑, 佐々木 栄太, 板倉 正典, 上田 宏, 内田 浩二
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 呼気オミックスによる硫黄代謝解析と新型コロナ感染症2022

    • Author(s)
      赤池孝章
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 超硫黄分子の発見と感染防御・免疫・代謝制御に関する研究2022

    • Author(s)
      赤池孝章
    • Organizer
      第3回 太田原豊一賞 受賞講演
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 活性酸素シグナル~酸素生物学~そして硫黄生物学:三つの領域を超えて見えてきた世界2022

    • Author(s)
      赤池孝章
    • Organizer
      第2回レドックスR&D戦略委員会 春のシンポジウム―最先端技術が切り拓くレドックスバイオロジー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 呼気オミックスと未来型医療:ヒューマンエアローム事業の創成2022

    • Author(s)
      赤池孝章
    • Organizer
      SAカレッジ21年度コースIII月例会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレス疾患病態解析における分析技術の新展開2021

    • Author(s)
      内田 浩二
    • Organizer
      第74回日本酸化ストレス学会・第21回日本NO学会合同学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 抗酸化性食品成分によるタンパク質自然修飾を介した生体恒常性維持機構2021

    • Author(s)
      板倉 正典, 内田 浩二
    • Organizer
      第48回日本毒性学会学術年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ポリフェノール修飾タンパク質に対する高親和性ペプチドの解析2021

    • Author(s)
      山本 広史, 佐々木 栄太, 阿南 優佑, 板倉 正典, 内田 浩二
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] メチルグリオキサール修飾タンパク質に対する新規モノクローナル抗体の開発2021

    • Author(s)
      井上 慎也, 阿南 優佑, 板倉 正典, 内田 浩二
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マロンジアルデヒド特異的モノクローナル抗体の解析2021

    • Author(s)
      三浦 由香子, 林 世映, 糸井 海星, 板倉 正典, 内田 浩二
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ポリフェノール修飾タンパク質によるヒストン結合を介した細胞保護作用2021

    • Author(s)
      山口 公輔, 板倉 正典, 北澤 麗磨, 林 世映, 永田 宏次, 柴田 貴広, 赤川 貢, 内田 浩二
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 酸化修飾タンパク質による自然免疫活性化機構の解明2021

    • Author(s)
      備前 知風優, 山口 公輔, 林 世映, 板倉 正典, 内田 浩二
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 医食同源:食と自然治癒力2021

    • Author(s)
      内田 浩二
    • Organizer
      第94回日本生化学会大会シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 抗酸化性食品成分によるタンパク質自然修飾とヒストンを介した生体応答2021

    • Author(s)
      板倉 正典, 内田 浩二
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] EGCGによるタンパク質修飾を介したヒストン結合性分子の産生2021

    • Author(s)
      山口 公輔, 板倉 正典, 北澤 麗磨, 林世映, 永田 宏次, 柴田 貴広, 赤川 貢, 内田 浩二
    • Organizer
      レドックスR&D戦略委員会 第1回 若手シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 硫黄呼吸の生命進化論2021

    • Author(s)
      赤池孝章
    • Organizer
      第20回日本ミトコンドリア学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] レドックスとエネルギー代謝の超硫黄パラダイム2021

    • Author(s)
      赤池孝章
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 硫黄呼吸の革新的イメージングの開発と応用2021

    • Author(s)
      赤池孝章
    • Organizer
      新領域創成のための挑戦研究デュオ~Frontier Research in Duo (FRiD)~ 公開セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 呼気オミックスと未来型医療2021

    • Author(s)
      赤池孝章
    • Organizer
      第46回日本医用マススペクトル学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 超硫黄分子による生体防御学の新たな潮流2021

    • Author(s)
      赤池孝章
    • Organizer
      第32回日本生体防御学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 超硫黄分子による感染免疫制御とエネルギー代謝2021

    • Author(s)
      赤池孝章
    • Organizer
      第41回阿蘇シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 超硫黄分子による電子転移反応とエネルギー代謝2021

    • Author(s)
      赤池孝章
    • Organizer
      生理研研究会2021「生命を支える硫黄生物学研究の最前線」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Sulfur respiration highly conserved and evolved in microbiota and organisms including human2021

    • Author(s)
      Takaaki Akaike
    • Organizer
      World Microbe Forum 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 呼気オミックスによる新型コロナ感染診断法と未来型医療2021

    • Author(s)
      赤池孝章
    • Organizer
      第81回分析化学討論会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 超硫黄代謝と呼気オミックス2021

    • Author(s)
      赤池孝章
    • Organizer
      第3回国際活性硫黄研究会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 超硫黄生物学:エネルギー代謝とレドックスシグナル2021

    • Author(s)
      赤池孝章
    • Organizer
      第74回日本酸化ストレス学会・第21回日本NO学会合同学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 新型コロナの呼気オミックス解析と未来型呼気医療2021

    • Author(s)
      赤池孝章
    • Organizer
      第30回バイオメディカル研究会「健康を測るセンシング技術」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 酸化修飾による新規エピゲノム調節機構2021

    • Author(s)
      上原 孝
    • Organizer
      日本薬学会第141年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ニトロソ化ストレス作用機構に類似した外来性環境物質の探索2021

    • Author(s)
      上原 孝
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] DNAメチル化および遺伝子発現に対する一酸化窒素の影響2021

    • Author(s)
      飯島悠太, 水島藤太, 中原健吾, 松下洋輔, 片桐豊雅, 上原 孝
    • Organizer
      第140回日本薬理学会近畿部会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 抗酸化剤機能のパラダイムシフト2021

    • Author(s)
      内田浩二
    • Organizer
      日本農芸化学会2021年度大会「抗酸化研究の新展開」シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 酸化型ビタミンC修飾タンパク質とヒストンH2Bの相互作用メカニズムの解明2021

    • Author(s)
      板倉正典, 山口公輔, 佐々木栄太, 吉武淳, 柴田貴広, 大野礼一, 永井竜児, 内田浩二
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ポリフェノール修飾タンパク質によるヒストン結合を介した細胞保護作用2021

    • Author(s)
      山口公輔, 板倉正典, 佐々木栄太, 赤川貢, 内田浩二
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ピロール化タンパク質による抗DNA自己抗体産生機構に関する研究2021

    • Author(s)
      林世映, 近澤未歩, 板倉正典, 佐々木栄太, 松田知成, 内田浩二
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 抗体工学を利用した二重交差性自己抗体の解析2021

    • Author(s)
      阿南優佑, 佐々木栄太, 板倉正典, 上田宏, 内田浩二
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ファージディスプレイ法によるポリフェノール修飾タンパク質結合ペプチドの探索2021

    • Author(s)
      山本広史, 佐々木栄太, 板倉正典, 内田浩二
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アスコルビン酸の関与するピロール化タンパク質の形成2021

    • Author(s)
      吉武淳, 柴田貴広, 内田浩二
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 低密度リポタンパク質における酸化リン脂質修飾構造の解析2021

    • Author(s)
      大塚優人, 青山拓生, 平出直哉, 内田浩二, 柴田貴広
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 活性硫黄分子によるシグナル伝達と代謝制御2021

    • Author(s)
      赤池孝章
    • Organizer
      第1回レドックスR&D戦略委員会シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 活性硫黄分子によるシグナル伝達と代謝制御2021

    • Author(s)
      赤池孝章
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 新型コロナの感染予防制御とポストコロナ時代の先進医療2021

    • Author(s)
      赤池孝章
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ユニークなタンパク質修飾反応リポキシデーション2020

    • Author(s)
      内田浩二
    • Organizer
      第93回 日本生化学会大会「新たな酸化脂質研究の潮流」シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ApoE欠損マウスにおけるピロール化リジンの多重交差性抗DNA抗体産生促進に関する研究2020

    • Author(s)
      林世映, 近澤未歩, 板倉正典, 佐々木栄太, 内田浩二
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ポリフェノール修飾タンパク質によるヒストンH2B結合を介した抗炎症作用2020

    • Author(s)
      山口公輔, 板倉正典, 近澤未歩, 佐々木栄太, 赤川貢, 内田浩二
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 細胞外ヒストンの細胞障害性に対する最終糖化産物(AGEs)の保護効果2020

    • Author(s)
      北澤麗麿, 板倉正典, 近澤未歩, 佐々木栄太, 内田浩二
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 自己免疫疾患における抗DNA抗体の解析2020

    • Author(s)
      阿南優佑, 佐々木栄太, 板倉正典, 近澤未歩, 上田宏, 内田浩二
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒストンH2Bへの結合を介した最終糖化産物(AGEs)によるプラスミノーゲン活性調節と炎症制御2020

    • Author(s)
      板倉正典, 近澤未歩, 佐々木栄太, 内田浩二
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] リポキシデーションによるタンパク質自然修飾2020

    • Author(s)
      内田浩二
    • Organizer
      第73回日本酸化ストレス学会「新しい酸化脂質解析法を用いたオキシリピッドバイオロジー研究」シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] エキスポソームに備える生体防御系としての自然抗体2020

    • Author(s)
      内田浩二
    • Organizer
      第94回日本薬理学会年会「薬理学・毒性学視点からアプローチするエクスポソーム研究」シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] NO・活性酸素シグナルから始まる硫黄生物学研究2020

    • Author(s)
      赤池孝章
    • Organizer
      プラズマバイオコンソーシアム2020年度研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 一酸化窒素によるDNA脱メチル化を介した遺伝子の誘導2020

    • Author(s)
      谷口理香子, 飯島悠太, 中原健吾, 高杉展正, 上原 孝
    • Organizer
      第61回日本生化学会 中国・四国支部例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 一酸化窒素による新たな遺伝子発現調節機構2020

    • Author(s)
      上原 孝
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] NOによる新規遺伝子発現調節機構:分子特異的酸化修飾抑制薬の開発を目指して2020

    • Author(s)
      上原 孝
    • Organizer
      第73回日本酸化ストレス学会/第20回日本NO学会 合同学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 一酸化窒素によるタンパク質ユビキチン化制御機構2020

    • Author(s)
      藤河香奈, 高杉展正, 上原 孝
    • Organizer
      第73回日本酸化ストレス学会/第20回日本NO学会 合同学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 一酸化窒素応答性遺伝子発現を介した神経細胞死誘導機構2020

    • Author(s)
      中原健吾, 宮崎育子, 高杉展正, 浅沼幹人, 上原 孝
    • Organizer
      第73回日本酸化ストレス学会/第20回日本NO学会 合同学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] レドックスを介したDNAメチル化制御機構2020

    • Author(s)
      上原 孝
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] NOによるDNA脱メチル化を伴って誘導される遺伝子の探索2020

    • Author(s)
      谷口理香子, 飯島悠太, 中原健吾, 髙杉展正, 上原 孝
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] タンパク質ジスルフィド結合のチオール化修飾と病態2019

    • Author(s)
      内田浩二
    • Organizer
      日本プロテオーム学会2019年大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Development of antibodies aimed to the detection of oxidized lipoproteins2019

    • Author(s)
      Uchida, K
    • Organizer
      Japan-Aston symposium on inflammation and oxidative stress
    • Related Report
      2019 Annual Research Report
  • [Presentation] Protein disulfide linkages as a target of oxidation2019

    • Author(s)
      Uchida, K
    • Organizer
      The 1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 抗酸化剤が持つ新たな細胞機能2019

    • Author(s)
      内田浩二
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ストレスで生じる様々なタンパク質修飾反応と生体応答2019

    • Author(s)
      内田浩二
    • Organizer
      第14回日本臨床ストレス応答学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Reactive persulfide mediate sulfur respiration in mitochondria via sulfide:quinone oxidoreductase2019

    • Author(s)
      Akaike T
    • Organizer
      The Society for Redox Biology and Medicine's 26th Annual Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 活性イオウ分子によるレドックスシグナルと代謝制御2019

    • Author(s)
      赤池孝章
    • Organizer
      第4回黒潮カンファレンス
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reactive persulfide mediates versatile redox signal functions with canonical signaling mimetics2019

    • Author(s)
      Akaike T
    • Organizer
      International Joint Conference of SFRR-Korea & HDRC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Reactive persulfide mediates versatile redox signal functions with canonical signaling mimetics2019

    • Author(s)
      Akaike T
    • Organizer
      2019 NIH-Japan-JSPS symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 活性硫黄シグナルと硫黄呼吸:哺乳類の新しいエネルギー代謝2019

    • Author(s)
      赤池孝章
    • Organizer
      第2回大隅ライフサイエンス研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 活性パースルフィドによるエネルギー代謝とタンパク質機能のレドックス制御2019

    • Author(s)
      赤池孝章
    • Organizer
      第92回日本生化学学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reactive persulfide mediates versatile redox signal functions with canonical signaling mimetics2019

    • Author(s)
      Akaike T
    • Organizer
      1st STINT-JSPS Joint Symposium in Sendai
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 活性イオウ分子種の代謝と抗酸化・抗炎症・免疫制御機能2019

    • Author(s)
      赤池孝章
    • Organizer
      JADCI/JSHDR2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] ミトコンドリアに硫黄呼吸を発見~古代生物の残存が現代に生きていた~2019

    • Author(s)
      赤池孝章
    • Organizer
      JASIS2019 ライフサイエンスイノベーションゾーン
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 進化する硫黄生物学:新しいレドックスバイオロジーの黎明2019

    • Author(s)
      赤池孝章
    • Organizer
      フリーラジカルスクール2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 硫黄呼吸の新規代謝経路の発見と生命科学へのインパクト2019

    • Author(s)
      赤池孝章
    • Organizer
      ライフサイエンスイノベーションセミナー
    • Related Report
      2019 Annual Research Report
  • [Presentation] 環境医学におけるイオウ毒性学のニューパラダイム:イオウ医学生物学の黎明2019

    • Author(s)
      赤池孝章
    • Organizer
      第46回日本毒性学会学術年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cysteine persulfide synthases mediate redox signaling and energy metabolism2019

    • Author(s)
      Akaike T.
    • Organizer
      The 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteine persulfide synthases mediate sulfur respiration and energy metabolism2019

    • Author(s)
      Akaike T.
    • Organizer
      The Kick-off Symposium of Advanced Graduate Program for Future Medicine and Health Care
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reactive sulfur species (RSS) mediate sulfur respiration in mitochondria and redox signaling2019

    • Author(s)
      Akaike T.
    • Organizer
      第 7 回 IRG(Inflammation and ReGeneration)Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Detection of novel S-nitrosylated proteins in neuronal cells2019

    • Author(s)
      Takashi Uehara
    • Organizer
      SfRBM2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リバースケミカルジェネティクスから解く酸化ストレスによりエピゲノム調節機構2019

    • Author(s)
      上原 孝
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Positive regulation of protein-disulfide isomerase activity via S -persulfidation2019

    • Author(s)
      Honami Ushirokawa and Takashi Uehara
    • Organizer
      第1回硫黄代謝の医学生物学に関する国際会議
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possible Role of Endogenous S-persulfidation in the Enzymatic Activity of ER Protein2019

    • Author(s)
      Honami Ushirokawa, Kenichi Yamaji, Sho Okuda, Eisuke Sugino, Nobumasa Takasugi, and Takashi Uehara
    • Organizer
      Hawaii IUTOX ICTXV 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of Ubiquitin-Proteasome System in ERAD via S-nitrosylation of UBE2D12019

    • Author(s)
      Kana Fujikawa, Kengo Nakahara, Nobumasa Takasugi, Akihiro Ito, and Takashi Uehara
    • Organizer
      Hawaii IUTOX ICTXV 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規タンパク質S-ニトロシル化阻害薬の構造活性相関2019

    • Author(s)
      野村亮介,奥田洸作,浮川太一,高杉展正,竹内靖雄,上原 孝
    • Organizer
      第135回日本薬理学会近畿部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 一酸化窒素応答性遺伝子発現による神経細胞死惹起機構の解析2019

    • Author(s)
      中原健吾,高杉展正,上原 孝
    • Organizer
      第135回日本薬理学会近畿部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ユビキチン結合酵素UBE2D1のS-ニトロシル化を介した小胞体関連分解調節機構2019

    • Author(s)
      藤河香奈,中原健吾,高杉展正,伊藤昭博,上原 孝
    • Organizer
      第19回日本NO学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] IgA deficiency causes spontaneous enteritis2019

    • Author(s)
      Adachi T, Watabe T, Nagaishi T, Watanabe M, Karasuyama H, Yoshikawa S.
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食品成分における腸管センシングの可視化解析2019

    • Author(s)
      福田 陽大, 越阪部 奈緒美, 安達 貴弘
    • Organizer
      日本食品免疫学会設立15周年記念学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食物アレルギー及び自己免疫疾患におけるIgAの影響2019

    • Author(s)
      小竹 久仁彦, 安達 貴弘
    • Organizer
      日本食品免疫学会設立15周年記念学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生体イメージングによる腸管機能の可視化解析2019

    • Author(s)
      安達 貴弘
    • Organizer
      第104回 日本栄養・食糧学会関東支部大会シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食をもって毒(さび)を制す2018

    • Author(s)
      内田浩二
    • Organizer
      東京大学農学部公開セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] MS-based identification of covalent adducts in oxidized LDL.2018

    • Author(s)
      Uchida, K.
    • Organizer
      Pre-Meeting Workshop “Methods in Lipid Oxidation” 25th Annual Meeting of the Society for Redox Biology and Medicine (SfRBM 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脂質酸化を起点とするタンパク質アダクトーム2018

    • Author(s)
      柴田貴広, 内田浩二
    • Organizer
      脂質酸化を起点とするバイオロジーの新展開」シンポジウム. 第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アポEが関与するオキシリポクオリティ2018

    • Author(s)
      内田浩二
    • Organizer
      第71回日本酸化ストレス学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Lipid peroxidation modification of proteins. Integrative approaches for the study of molecular and cellular lipoxidation2018

    • Author(s)
      Uchida, K.
    • Organizer
      ITN Masstrplan Workshop. Marie Sklodowska-Curie Innovative Training Networks ‘MASSTRPLAN’ MASS Spectrometry TRaining network for Protein Lipid adduct Analysis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical biology of reactive sulfur species and its metabolome analysis.2018

    • Author(s)
      Akaike T.
    • Organizer
      2018 Annual Medical Technology Conference 3rd Annual Conference New Frontiers in Mass Spectrometry Clinical and Biomedical Applications
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ミトコンドリアのイオウ呼吸とイオウストレス2018

    • Author(s)
      赤池孝章
    • Organizer
      山形分子生物研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新しいエネルギー代謝機構:イオウ呼吸の発見と生理機能解明2018

    • Author(s)
      赤池孝章
    • Organizer
      平成30年度東北大学医学系病理同窓会特別公演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Translation-coupled persulfide synthases (PERSs) involved critically in sulfur respiration and energy metabolism2018

    • Author(s)
      Akaike T.
    • Organizer
      10th Internatinal Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Persulfide synthase coupled with translation mediates sulfur respiration in mammals2018

    • Author(s)
      Akaike T.
    • Organizer
      KCL Redox Biology & Medicine Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sulfur respiration as a target for mitochondrial disease2018

    • Author(s)
      赤池孝章
    • Organizer
      7 SEAS PROJECT Research meeting 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] イオウ呼吸:レドックス研究の新たなパラダイム2018

    • Author(s)
      赤池孝章
    • Organizer
      Free Radical Summer School 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Cysteine persulfide synthases coupled with translation mediate sulfur respiration and redox signaling2018

    • Author(s)
      Akaike T
    • Organizer
      The 43rd FEBS Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteinyl-tRNA synthetase (CARS) controls endogenous hydropersulfide production and mitochondrial respiration2018

    • Author(s)
      Akaike T
    • Organizer
      The 19th biennial meeting for the Society for Free Radical Research International (SFRRI)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sulfur respiration in mammals and its implication for tumor biology2018

    • Author(s)
      Takaaki Akaike, Tomoaki Ida, Md. Morshedul Alam, Akira Nishimura, Masanobu Morita, Tetsuro Matsunaga, Hozumi Motohashi.
    • Organizer
      The Cold Spring Harbor Asia Conference on Cancer & Metabolism
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自然抗体エピトープを有する食品成分の探索2018

    • Author(s)
      三輪恭行、今堀夏奈美、古橋麻衣、柴田貴広、内田浩二
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリフェノールオキシダーゼによる茶カテキンの自然抗体リガンド生成能の増強2018

    • Author(s)
      今堀夏奈美、三輪恭行、李相美、柴田貴広、内田浩二
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アポリポプロテインEによるピロール化タンパク質の制御2018

    • Author(s)
      平出直哉、柴田貴広、内田浩二
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cysteine polysulfidation governed by cysteinyl-tRNA synthetase (CARSs)2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      Se2017 - 200 Years of Selenium Research (The 11th International Symposium on Selenium in Biology and Medicine and The 5th International Conference on Selenium in the Environment and Human Health)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteinyl-tRNA synthetase (CARS) controls endogenous hydropersulfide production and mediates mitochondrial functions and bioenegetics2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      S-Bio 2017 Plant and Human Sulfur Biology Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cysteinyl-tRNA synthetase governs endogenous hydropersulfide production and mediates mitochondrial functions and bioenergetics2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      AARS2017: IUBMB Focused Meeting on Aminoacyl-tRNA Synthetase
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 呼気オミックスと個別化医療2021

    • Author(s)
      赤池孝章, 松永哲郎, 井田智章, 高田 剛, Jung Minkyung, 守田匡伸, 本橋ほづみ
    • Total Pages
      4
    • Publisher
      Precision Medicine (株)北隆館
    • Related Report
      2021 Annual Research Report
  • [Book] 生命を支える超硫黄分子の代謝と革新的な計測技術2021

    • Author(s)
      本橋ほづみ, 赤池孝章
    • Total Pages
      3
    • Publisher
      生化学 (公社)日本生化学会
    • Related Report
      2021 Annual Research Report
  • [Book] 超硫黄分子の化学と代謝:超硫黄生物学の創成とオミックス先制医療への展望2021

    • Author(s)
      赤池孝章, 松永哲郎, 高田 剛
    • Total Pages
      9
    • Publisher
      生化学 (公社)日本生化学会
    • Related Report
      2021 Annual Research Report
  • [Book] 超硫黄代謝物の化学と代謝2021

    • Author(s)
      高田 剛, 松永哲郎, 赤池孝章
    • Total Pages
      4
    • Publisher
      実験医学 (株)羊土社
    • Related Report
      2021 Annual Research Report
  • [Book] 活性硫黄分子種によるエネルギー代謝とタンパク質劣化防止機能2021

    • Author(s)
      高田剛, 松永哲郎, 赤池孝章
    • Publisher
      バイオサイエンスとインダストリー
    • Related Report
      2020 Annual Research Report
  • [Book] 食と健康を結ぶメディカルサイエンス2020

    • Author(s)
      内田 浩二
    • Total Pages
      242
    • Publisher
      羊土社
    • ISBN
      9784758103879
    • Related Report
      2020 Annual Research Report
  • [Book] 食と健康を結ぶメディカルサイエンス “リポキシデーションによるタンパク質の自然修飾”2020

    • Author(s)
      内田 浩二
    • Publisher
      羊土社
    • ISBN
      9784758103879
    • Related Report
      2020 Annual Research Report
  • [Book] 食と健康を結ぶメディカルサイエンス “システイン残基におけるユニークな自然修飾”2020

    • Author(s)
      中島史恵、柴田貴広、内田浩二
    • Publisher
      羊土社
    • ISBN
      9784758103879
    • Related Report
      2020 Annual Research Report
  • [Book] 4. 抗酸化:活性パースルフィドによる制御2020

    • Author(s)
      高田剛, 松永哲郎, 赤池孝章
    • Publisher
      実験医学【食と健康を結ぶメディカルサイエンス】
    • Related Report
      2020 Annual Research Report
  • [Book] 茶ポリフェノールの生理機能と応用展開2019

    • Author(s)
      赤川貢、内田浩二
    • Publisher
      シーエムシー出版
    • ISBN
      9784781314334
    • Related Report
      2019 Annual Research Report
  • [Book] 再生医療2019

    • Author(s)
      高田剛、松永哲郎、赤池孝章
    • Publisher
      (株)メディカルレビュー社
    • Related Report
      2019 Annual Research Report
  • [Book] 月刊細胞(細胞)2019

    • Author(s)
      西村明、本橋ほづみ、赤池孝章
    • Publisher
      (株)ニュー・サイエンス社
    • Related Report
      2019 Annual Research Report
  • [Book] 学士会会報2019

    • Author(s)
      赤池孝章
    • Publisher
      一般社団法人学士会
    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] 第3回国際活性硫黄研究会2021

    • Related Report
      2021 Annual Research Report

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Published: 2017-06-01   Modified: 2024-03-28  

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