| Project/Area Number |
17H06173
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Masanobu Uchiyama 東京大学, 大学院薬学系研究科(薬学部), 教授 (00271916)
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| Co-Investigator(Kenkyū-buntansha) |
澤田 大介 岡山大学, 医歯薬学総合研究科, 教授 (00338691)
村中 厚哉 国立研究開発法人理化学研究所, 開拓研究本部, 専任研究員 (20374902)
神野 伸一郎 愛知学院大学, 薬学部, 教授 (20537237)
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| Project Period (FY) |
2017-05-31 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥212,290,000 (Direct Cost: ¥163,300,000、Indirect Cost: ¥48,990,000)
Fiscal Year 2021: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2020: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2019: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2018: ¥47,190,000 (Direct Cost: ¥36,300,000、Indirect Cost: ¥10,890,000)
Fiscal Year 2017: ¥92,300,000 (Direct Cost: ¥71,000,000、Indirect Cost: ¥21,300,000)
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| Keywords | π分子 / 光応答分子 / 機能性色素 / 光応答性分子 / 近赤 外光分子技術 / 機能性π分子 / 化学系薬学 / 有機化学 |
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| Outline of Final Research Achievements |
Complex pi-electron compounds that interact with light have long attracted interest, and have become increasingly important in recent years for potential applications in life science and materials science. However, there are still severe limitations in rational design, synthesis, and derivatization of π-electron organic molecules, as well as in their functional modification (absorption/emission properties, quantum yield, thermo-stability, etc.), and these issues have hampered their practical application in advanced technologies, including storage media, organic semiconductors, laser printers, photodynamic therapy of cancer, nonlinear optics, deodorants, and molecular imaging. Through this project, we have developed new synthetic methods, to extend theoretical principles, and to synthesize novel pi-electron molecules with unique functionalities suitable for next-generation technological applications.
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| Academic Significance and Societal Importance of the Research Achievements |
本プロジェクトでは、光エネルギー、特に生体にダメージを与えない可視光や近赤外光を利用して病気の診断や治療法の開発、ならびに生命現象の解明や制御を目指し研究を行い、生体内で光と反応する分子や、新たな診断技術の提案、こうした分子づくりのための新理論構築、そして光を利活用するための技術創出を実現・達成しました。
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| Assessment Rating |
Verification Result (Rating)
A
Result (Rating)
A: Progress in the research is steadily towards the initial goal. Expected research results are expected.
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