| Budget Amount *help |
¥205,790,000 (Direct Cost: ¥158,300,000、Indirect Cost: ¥47,490,000)
Fiscal Year 2021: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
Fiscal Year 2020: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Fiscal Year 2019: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2018: ¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
Fiscal Year 2017: ¥51,870,000 (Direct Cost: ¥39,900,000、Indirect Cost: ¥11,970,000)
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| Outline of Final Research Achievements |
We have elucidated the immune mechanisms involved in inflammation and tissue repair induced by organ damage, focusing on a mouse model of cerebral infarction. Inflammation occurs in the acute phase within one day after stroke, resulting in worsening of symptoms, but inflammation begins to subside on the third day or later. They found that macrophages and scavenger receptors expressed on the surface of macrophages are involved in this process. Furthermore, they found that a large number of regulatory T cells accumulate in the brain during the chronic phase after the second week of disease onset and contribute to the recovery of neurological symptoms by suppressing the excessive activation of microglia and astrocytes.
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