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Generation of neural network repair medicine

Research Project

Project/Area Number 17H06178
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neurosurgery
Research InstitutionOsaka University

Principal Investigator

YAMASHITA Toshihide  大阪大学, 医学系研究科, 教授 (10301269)

Project Period (FY) 2017-05-31 – 2022-03-31
Project Status Discontinued (Fiscal Year 2021)
Budget Amount *help
¥206,180,000 (Direct Cost: ¥158,600,000、Indirect Cost: ¥47,580,000)
Fiscal Year 2021: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2020: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2019: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2018: ¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2017: ¥56,420,000 (Direct Cost: ¥43,400,000、Indirect Cost: ¥13,020,000)
Keywords神経疾患 / 神経再生 / 神経回路 / 神経科学 / 中枢神経 / 免疫制御 / 脳・神経 / 脳神経疾患
Outline of Final Research Achievements

Peripheral and central nervous system (CNS) disorders (e.g., cerebrovascular disorders, brain, and spinal cord trauma, neurodegenerative diseases, and higher brain dysfunction) lead to spatial and temporal changes in the nervous system, immune system, vascular system, biological systems composed of various organs, and pathological conditions. I investigated disorders of neural networks in the CNS and the subsequent repair process from the viewpoint of the functional network of biological systems, and comprehensively elucidated the control mechanism underlying a series of processes in the spatiotemporal dynamics of biological systems. I clarified the mechanism of neural networks in the CNS by analyzing disorders of neural networks in the CNS and the functional recovery process, as seen in the dynamics of the whole biological system.

Academic Significance and Societal Importance of the Research Achievements

中枢神経系を生体システムにおける1臓器として捉え、生体システム全体が神経回路の障害と修復にどのように関わるかという観点からの研究は未だ発展途上にある。研究代表者が得た最近の知見は一流科学誌に掲載され、リーダーシップを発揮して本分野を牽引している。神経回路の障害とそれに続く修復の過程における生体の反応を「スクラップ・アンド・ビルド」の戦略と捉え、一連の反応の機構と意義を明らかにする研究を創成しており、生命科学において新たな潮流を作り出すものと期待される。本研究の成果は新たな治療法の創出につながり、難治神経疾患の克服に向けた戦略の雛形になることが期待できる。

Assessment Rating
Verification Result (Rating)

A+

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(10 results)
  • 2022 Research Progress Assessment (Verification Result) ( PDF )
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (67 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (26 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 26 results,  Open Access: 18 results) Presentation (39 results) (of which Int'l Joint Research: 12 results,  Invited: 34 results) Remarks (2 results)

  • [Journal Article] Age-dependent decline in remyelination capacity is mediated by apelin-APJ signaling2021

    • Author(s)
      Masumi Ito, Rieko Muramatsu, Yuki Kato, Bikram Sharma, Akiko Uyeda, Shogo Tanabe, Harutoshi Fujimura, Hiroyasu Kidoya, Nobuyuki Takakura, Yukio Kawahara, Masaki Takao, Hideki Mochizuki, Akiyoshi Fukamizu, Toshihide Yamashita
    • Journal Title

      Nature Aging

      Volume: 1 Issue: 3 Pages: 284-294

    • DOI

      10.1038/s43587-021-00041-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson’s disease2021

    • Author(s)
      Oda Wakana、Fujita Yuki、Baba Kousuke、Mochizuki Hideki、Niwa Hitoshi、Yamashita Toshihide
    • Journal Title

      Cell Death & Disease

      Volume: 12 Issue: 2 Pages: 181-181

    • DOI

      10.1038/s41419-021-03469-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proton-sensing receptor GPR132 facilitates migration of astrocytes2020

    • Author(s)
      Matoba Ken、Yamashita Shinya、Isaksen Toke Jost、Yamashita Toshihide
    • Journal Title

      Neuroscience Research

      Volume: 印刷中 Pages: 106-113

    • DOI

      10.1016/j.neures.2020.10.001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Netrin-G1 regulates microglial accumulation along axons and supports the survival of layer V neurons in the postnatal mouse brain.2020

    • Author(s)
      Fujita, Y., Nakanishi, T., Ueno, M., Itohara, S., and Yamashita, T.
    • Journal Title

      Cell Reports

      Volume: 31 Issue: 4 Pages: 107580-107580

    • DOI

      10.1016/j.celrep.2020.107580

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microglial depletion under thalamic hemorrhage ameliorates mechanical allodynia and suppresses aberrant axonal sprouting2020

    • Author(s)
      Hiraga Shin-ichiro、Itokazu Takahide、Hoshiko Maki、Takaya Hironobu、Nishibe Mariko、Yamashita Toshihide
    • Journal Title

      JCI Insight

      Volume: 5 Issue: 3

    • DOI

      10.1172/jci.insight.131801

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Repulsive guidance molecule A suppresses adult neurogenesis.2020

    • Author(s)
      Isaksen, T.J., Fujita, Y. and Yamashita, T.
    • Journal Title

      Stem Cell Rep

      Volume: 14 Issue: 4 Pages: 677-691

    • DOI

      10.1016/j.stemcr.2020.03.003

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of HDAC increases BDNF expression and promotes neuronal rewiring and functional recovery after brain injury2020

    • Author(s)
      Sada Naoki、Fujita Yuki、Mizuta Nanano、Ueno Masaki、Furukawa Takahisa、Yamashita Toshihide
    • Journal Title

      Cell Death & Disease

      Volume: 11 Issue: 8 Pages: 655-655

    • DOI

      10.1038/s41419-020-02897-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurons promote encephalitogenic CD4+ lymphocyte infiltration in experimental autoimmune encephalomyelitis2020

    • Author(s)
      Nakazato Yuki、Fujita Yuki、Nakazato Masamitsu、Yamashita Toshihide
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 655-655

    • DOI

      10.1038/s41598-020-64363-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protocol for Co-culture of Microglia with Axons2020

    • Author(s)
      Fujita Yuki、Yamashita Toshihide
    • Journal Title

      STAR Protocols

      Volume: 1 Issue: 3 Pages: 100111-100111

    • DOI

      10.1016/j.xpro.2020.100111

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Netrin-G1 regulates microglial accumulation along axons and supports the survival of layer V neurons in the postnatal mouse brain.2020

    • Author(s)
      Fujita, Y., Nakanishi, T., Ueno, M., Itohara, S. and Yamashita, T.
    • Journal Title

      Cell Rep

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system2019

    • Author(s)
      Hamaguchi Machika、Muramatsu Rieko、Fujimura Harutoshi、Mochizuki Hideki、Kataoka Hirotoshi、Yamashita Toshihide
    • Journal Title

      eLife

      Volume: 8

    • DOI

      10.7554/elife.41869

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased Expression of Fibronectin Leucine-Rich Transmembrane Protein 3 in the Dorsal Root Ganglion Induces Neuropathic Pain in Rats2019

    • Author(s)
      Yamada Moe、Fujita Yuki、Hayano Yasufumi、Hayakawa Hideki、Baba Kousuke、Mochizuki Hideki、Yamashita Toshihide
    • Journal Title

      The Journal of Neuroscience

      Volume: 39 Issue: 38 Pages: 7615-7627

    • DOI

      10.1523/jneurosci.0295-19.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microglia suppress the secondary progression of autoimmune encephalomyelitis2019

    • Author(s)
      Tanabe Shogo、Saitoh Shohei、Miyajima Hisao、Itokazu Takahide、Yamashita Toshihide
    • Journal Title

      Glia

      Volume: 67 Issue: 9 Pages: 1694-1704

    • DOI

      10.1002/glia.23640

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of gene expression profile of the spinal cord of sprouting-capable neonatal and sprouting-incapable adult mice2019

    • Author(s)
      Tsujioka Hiroshi、Yamashita Toshihide
    • Journal Title

      BMC Genomics

      Volume: 20 Issue: 1 Pages: 619-619

    • DOI

      10.1186/s12864-019-5974-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-repulsive guidance molecule-a antibody treatment and repetitive transcranial magnetic stimulation have synergistic effects on motor recovery after spinal cord injury2019

    • Author(s)
      Nakanishi Toru、Fujita Yuki、Tanaka Takashi、Yamashita Toshihide
    • Journal Title

      Neuroscience Letters

      Volume: 709 Pages: 134329-134329

    • DOI

      10.1016/j.neulet.2019.134329

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuropilin-1-mediated pruning of corticospinal tract fibers is required for motor recovery after spinal cord injury2019

    • Author(s)
      Nakanishi Toru、Fujita Yuki、Yamashita Toshihide
    • Journal Title

      Cell Death & Disease

      Volume: 10 Issue: 2 Pages: 67-67

    • DOI

      10.1038/s41419-019-1338-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] B-1a lymphocytes promote oligodendrogenesis during brain development.2018

    • Author(s)
      Tanabe, S., Yamashita, T.
    • Journal Title

      Nat. Neurosci.

      Volume: 21 Issue: 4 Pages: 506-516

    • DOI

      10.1038/s41593-018-0106-4

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Class I histone deacetylase (HDAC) inhibitor CI-994 promotes functional recovery following spinal cord injury2018

    • Author(s)
      Zhang Suxiang、Fujita Yuki、Matsuzaki Rieko、Yamashita Toshihide
    • Journal Title

      Cell Death & Disease

      Volume: 9 Issue: 5 Pages: 460-460

    • DOI

      10.1038/s41419-018-0543-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis2018

    • Author(s)
      Tanabe Shogo、Fujita Yuki、Ikuma Kaori、Yamashita Toshihide
    • Journal Title

      Cell Death & Disease

      Volume: 9 Issue: 11 Pages: 506-516

    • DOI

      10.1038/s41419-018-1118-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental abnormality contributes to cortex-dependent motor impairments and higher intracortical current requirement in the reeler homozygous mutants2018

    • Author(s)
      Nishibe Mariko、Katsuyama Yu、Yamashita Toshihide
    • Journal Title

      Brain Structure and Function

      Volume: 印刷中 Issue: 6 Pages: 2575-2587

    • DOI

      10.1007/s00429-018-1647-8

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Macrophage P2X4 receptors augment bacterial killing and protect against sepsis2018

    • Author(s)
      Csoka Balazs、Nemeth Zoltan H.、Szabo Ildiko、Davies Daryl.、Varga Zoltan V.、Paloczi Janos、Falzoni Simonetta、Di Virgilio Francesco、Muramatsu Rieko、Yamashita Toshihide、Pacher Pal、Hasko Gyorgy
    • Journal Title

      JCI Insight

      Volume: 3 Issue: 11

    • DOI

      10.1172/jci.insight.99431

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Myotube-derived factor promotes oligodendrocyte precursor cell proliferation2018

    • Author(s)
      Akino Nakasone, Rieko Muramatsu, Yuki Kato, Yukio Kawahara and Toshihide Yamashita
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 500 Issue: 3 Pages: 609-613

    • DOI

      10.1016/j.bbrc.2018.04.118

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica.2018

    • Author(s)
      Harada K, Fujita Y, Okuno T, Tanabe S, Koyama Y, Mochizuki H, Yamashita T
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 34-34

    • DOI

      10.1038/s41598-017-18362-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peripherally derived FGF21 promotes remyelination in the central nervous system.2017

    • Author(s)
      Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, Yoshida M, Konishi M, Itoh N, Mochizuki H, Yamashita T.
    • Journal Title

      J Clin Invest.

      Volume: 127 Issue: 9 Pages: 3496-3509

    • DOI

      10.1172/jci94337

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of p73 in ependymal cells during the perinatal period leads to aqueductal stenosis2017

    • Author(s)
      Fujitani Masashi、Sato Ryohei、Yamashita Toshihide
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 12007-12007

    • DOI

      10.1038/s41598-017-12105-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased cohesion in the brain leads to defective synapse development and anxiety-related behavior2017

    • Author(s)
      Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T.
    • Journal Title

      J. Exp. Med.

      Volume: 印刷中 Issue: 5 Pages: 1431-1452

    • DOI

      10.1084/jem.20161517

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 生体システムの制御による神経回路修復治療薬の開発2021

    • Author(s)
      山下俊英
    • Organizer
      第126回日本解剖学会総会・全国学術集会/ 第98回日本生理学会大会合同大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] The spatiotemporal dynamics in the biological systems regulate the neuronal network in the central nervous system.2020

    • Author(s)
      Toshihide Yamashita
    • Organizer
      FENS 2020 Virtual Forum
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Microglial depletion under thalamic hemorrhage ameliorates pain-like behavior and suppresses aberrant axonal sprouting.2020

    • Author(s)
      Hiraga, S., Itokazu, T., Hoshiko, M., Takaya, H., Nishibe, M., Yamashita, T.
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 中枢神経回路形成におけるクロマチンの三次元的な構造変化の役割2020

    • Author(s)
      藤田 幸、山下 俊英
    • Organizer
      第96回 日本解剖学会近畿支部学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 延髄錐体切断後の新生児と成体の遺伝子発現プロファイルの比較2020

    • Author(s)
      辻岡洋、山下俊英
    • Organizer
      第96回日本解剖学会近畿支部学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of therapeutic strategies to repair neuronal network for the central nervous system diseases.2020

    • Author(s)
      Yamashita, T.
    • Organizer
      The 2nd Osaka University-OIST Symposium
    • Related Report
      2019 Annual Research Report
  • [Presentation] RGM protein in neuro-degeneration and neuro-regeneration.2019

    • Author(s)
      Yamashita, T.
    • Organizer
      American Spinal Injury Association SCI Summit Annual Scientific Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Challenges for finding a cure for patients with the CNS injuries.2019

    • Author(s)
      Yamashita, T.
    • Organizer
      The 2nd International Symposium of Junior Neuroscience Investigators
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of the drug to target myelin-derived axon growth inhibitors to repair neuronal network for the central nervous system diseases.2019

    • Author(s)
      Yamashita, T.
    • Organizer
      14th Biennial ISN Satellite Meeting on Myelin Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The spatiotemporal dynamics in the biological systems regulate the neuronal network in the central nervous system.2019

    • Author(s)
      Yamashita, T.
    • Organizer
      IBRO (International Brain Research Organization)-MENA Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中枢神経回路の再編成を制御するメカニズムと治療法の確立2019

    • Author(s)
      山下俊英
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の修復機構と生体システム連関2019

    • Author(s)
      山下俊英
    • Organizer
      老化メカニズムの解明・制御プロジェクト「老化研究推進・支援拠点」主催研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の再編成を制御するメカニズムと治療法の確立2019

    • Author(s)
      山下俊英
    • Organizer
      国立病院機構新潟病院 神経可塑性と機能回復に関する医学講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の再編成を制御するメカニズムと治療法の確立2019

    • Author(s)
      山下俊英
    • Organizer
      Neuro2019 神経化学会理事会企画シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 神経科学と免疫学の融合研究2019

    • Author(s)
      山下俊英
    • Organizer
      リエゾンラボ炎症シンポジウムー北大、阪大、新潟大、神戸大合同研究発表会―
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の再編成を制御するメカニズム2019

    • Author(s)
      山下俊英
    • Organizer
      第2回極みプロジェクトシンポジウム/第6回イメージング数理研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中枢神経の保護と再生のための治療戦略2019

    • Author(s)
      山下俊英
    • Organizer
      第30回日本緑内障学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の修復機構の解明と治療薬の開発2019

    • Author(s)
      山下俊英
    • Organizer
      アステラス病態代謝研究会 設立50周年記念講演
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の障害と修復を制御するメカニズムと治療薬の開発2019

    • Author(s)
      山下俊英
    • Organizer
      第 37 回日本神経治療学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の再編成を制御するメカニズムと治療薬の開発2019

    • Author(s)
      山下俊英
    • Organizer
      第TOKYOニューロサイエンス研究会~病態に対する神経系のレジリエンス
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The role of cohesin in the central nervous system. 69th Annual Meeting of Korean Association of Anatomists2019

    • Author(s)
      Fujita, Y., Yamashita, T.
    • Organizer
      69th Annual Meeting of Korean Association of Anatomists, JAA-KAA Joint Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中枢神経回路の障害と修復を制御するメカニズム2019

    • Author(s)
      山下俊英
    • Organizer
      第42回日本脳神経外傷学会 特別講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The spatiotemporal dynamics in the biological systems regulate the neuronal network in the central nervous system.2019

    • Author(s)
      山下俊英
    • Organizer
      Campus Asia Faculty Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中枢神経回路の修復を制御する生体システム2018

    • Author(s)
      山下俊英
    • Organizer
      第41回日本神経科学大会 教育講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の修復を制御する生体システム2018

    • Author(s)
      山下俊英
    • Organizer
      第61回日本神経化学会大会・第40回日本生物学的精神医学会 シンポジウム講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 中枢神経障害と神経―生体システム連関2018

    • Author(s)
      山下俊英
    • Organizer
      神経発達・再生研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の形成と修復を制御する生体システム2018

    • Author(s)
      山下俊英
    • Organizer
      第40回神経組織培養研究会 シンポジウム講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The spatiotemporal dynamics in the biological systems regulate the neuronal network in the central nervous system.2018

    • Author(s)
      山下俊英
    • Organizer
      5th IBRO-ARC Neuroscience School
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The spatiotemporal dynamics in the biological systems regulate the neuronal network in the central nervous system.2018

    • Author(s)
      山下俊英
    • Organizer
      Istanbul Techinical University Molecular Biology and Genetics International Student Congress ‘18
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経発達障害群の染色体重複による発症の機序2018

    • Author(s)
      山下俊英
    • Organizer
      日本ADHD学会第9回総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The spatiotemporal dynamics in the biological systems regulate the neuronal network in the central nervous system.2018

    • Author(s)
      山下俊英
    • Organizer
      The 2nd Osaka University and Karolinska Institute Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biological mechanisms of neural rewiring regulation in the central nervous system2017

    • Author(s)
      山下俊英
    • Organizer
      Basic Research Forum
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Microglia control the survival and degeneration of developing cortical neurons.2017

    • Author(s)
      山下俊英
    • Organizer
      第40回日本神経科学大会エルゼビア/NSR協賛シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の修復と再生2017

    • Author(s)
      山下俊英
    • Organizer
      第16回九州脳・高血圧・循環制御研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の修復のメカニズムと細胞外環境2017

    • Author(s)
      山下俊英
    • Organizer
      第58回日本組織細胞化学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の再編成を制御する手法の構築2017

    • Author(s)
      山下俊英
    • Organizer
      第10回神経機能回復セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 神経再生機構:Rho-ROCKシグナルを中心に2017

    • Author(s)
      山下俊英
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Challenges for finding a cure for patients with the CNS injuries.2017

    • Author(s)
      山下俊英
    • Organizer
      2nd IBRO-ARC-ISN School, Neurogenetics from Animal Models to Precision Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The spatiotemporal dynamics in the biological systems regulate the neuronal network in the central nervous system.2017

    • Author(s)
      山下俊英
    • Organizer
      The 7th NIF Winter School on Advanced Immunology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 大阪大学大学院医学系研究科分子神経科学

    • URL

      http://www.med.osaka-u.ac.jp/pub/molneu/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2017 Annual Research Report
  • [Remarks] 大阪大学大学院医学系研究科 分子神経科学

    • URL

      http://www.med.osaka-u.ac.jp/pub/molneu/index.html

    • Related Report
      2018 Annual Research Report

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Published: 2017-06-01   Modified: 2023-10-16  

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