Development of Chiral Silicon Technology
| Project/Area Number |
17H06235
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| Research Category |
Grant-in-Aid for Challenging Research (Pioneering)
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry and related fields
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| Research Institution | Kyushu University |
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Principal Investigator |
Igawa Kazunobu 九州大学, 先導物質化学研究所, 助教 (80401529)
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| Project Period (FY) |
2017-06-30 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2017: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Keywords | 有機合成化学 / キラルケイ素分子 / 不斉合成 / 有機ケイ素化学 / 生物活性 / キラルシラカルボン酸誘導体 / キラルシラヒドロインダン誘導体 / キラルテクノロジー / 生物活性物質 / 生理活性物質 / 有機化学 |
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| Outline of Final Research Achievements |
In this study, we have developed practical asymmetric synthetic methods for chiral silicon molecules having asymmetric silicon atom to open up new chiral technology based on their unique properties. As the results, we have achieved asymmetric synthesis of chiral silacycles, e.g. chiral silacyclopentanes, chiral silaoxane with newly developed asymmetric reactions, and found that some of the derivatives show substantial bioactivity.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では，多様かつ高度に官能基化されたキラルケイ素分子が合成可能であり，それらに生物活性などの有用な機能が発現することを明らかにした．これらの成果は，医薬品開発や機能性分子開発において限定されてきた「構成元素」を拡張することで，合成可能な分子群が飛躍的に展開されることを示し，今後，有機合成化学を基盤とする多くの研究領域に大きな波及効果をもたらすことが期待される．
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Preparation of Enantioenriched Chiral Organic Molecules by Dynamic Asymmetric Induction from Outer Chiral Source2019
Author(s)
Igawa, K.; Kawasaki, Y.; Ano, Y.; Kashiwagi, T.; Ogawa, K.; Hayashi, J.; Morita, R.; Yoshioka, Y.; Kazuhiro, U.; Tomooka, K.
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Journal Title
Chemistry Letters
Volume: 48
Issue: 7
Pages: 726-729
DOI
NAID
Related Report
Peer Reviewed / Open Access
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