| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2019: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2018: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
The SCN（suprachiasmatic nucleus） neurons receive information about light intensity in the environment via direct synaptic connections with the retina, which adapts the phase of SCN oscillator to the photoperiod. The SCN clock then synchronizes overt rhythms in physiology and behavior. Per1 and Per2 transcription is rapidly induced by light in a time-of-day-dependent manner. The responsiveness of Per1 mRNA to light is closely related to behavioral phase delays induced by light. It is well known that not only photic but also nonphotic stimuli can entrain the SCN clock, and Drug A acting on Drug A receptor in retina have been investigated to modulate the circadian rhythm by causing a phase shift in the rhythm in the peripheral or central nervous system. The acute and circadian time-dependent reduction in Per1 and/or Per2 mRNA in SCN and liver by Drug A receptor agonist strongly correlated with phase resetting in response to the drug.
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