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Construction of Cynomologus Monkey Model for Hereditary Retinal Diseases : Diseases Mechanisms and Therapeutic

Research Project

Project/Area Number 17H06276
Research Category

Grant-in-Aid for Challenging Research (Pioneering)

Allocation TypeSingle-year Grants
Research Field Surgery related to the biological and sensory functions and related fields
Research Institution独立行政法人国立病院機構(東京医療センター臨床研究センター)

Principal Investigator

岩田 岳  独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 部長 (90374157)

Co-Investigator(Kenkyū-buntansha) 溝田 淳  帝京大学, 医学部, 教授 (10239262)
下澤 律浩  国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 霊長類医科学研究センター, 主任研究員 (50300786)
Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Granted (Fiscal Year 2019)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2017: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Keywords医歯薬学 / 外科系臨床医学 / 眼科学 / 眼生化学・分子生物学 / ドルーゼン
Outline of Annual Research Achievements

ヒトは情報の約8割を視覚情報に頼っており、これが障害されると通常の生活に著しい影響を及ぼす。日本人の主な失明原因である緑内障、加齢黄斑変性、一部の遺伝性網膜疾患はヒトを含む高等霊長類にのみ存在する眼球部位で発症しており、通常使われる実験動物(マウス、ラット、ウサギ、イヌ、ネコ、ブタなど)ではより厳密な疾患モデル動物を作製することは困難である。また、多くの眼疾患はゲノム配列と強く相関しており、原因遺伝子や感受性遺伝子は眼疾患のリスク因子として作用する。眼疾患と関連するゲノム配列を高等霊長類で再現することが可能になれば、ヒトの眼疾患を再現し、病態の解明や治療法の開発に必要な動物モデルとして利用できる。本研究は最新のCRISPR/Cas9遺伝子改変技術をヒトと眼球構造がきわめて類似するカニクイザルに応用し、ヒトの難治性眼疾患を再現して、病態の解明や治療法の開発に利用することを目的とする。緑内障、加齢黄斑変性、遺伝性網膜疾患に関わる遺伝子のノックインカニクイザルの作製をめざす。この研究によって、より患者の病態に近い眼疾患モデル動物の作製が期待され、これまでのマウスを中心とした遺伝子解析動物よりも精度の高い情報が得られると期待される。

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

カニクイザルモデルに対してGnRH agonist、FSHおよびhCGを用いたホルモン投与方法により成熟卵の採取を行ったところ、成熟卵採取において効果的に採取できたり、あるいはできなかったことがあった。カニクイザルではマウスの系統とは異なり、遺伝的背景が揃っていないことや個体の年齢や状態も個々に異なることによって、適した採卵方法ではない可能性が示唆された。また、採卵個体の体重変化において、GnRH agonist投与開始から採卵時までのおよそ一ヶ月の間に、顕著な減少が見られ、本採卵方法による個体の健康状態への影響が考えられた。一方、GnRH antagonistを利用したホルモン投与方法では、GnRH agonistを用いた場合よりも投与から採卵までの期間の短縮および体重減少がほとんど見られないことから、より効率的な卵採取が可能と考えられた。卵数が十分に準備でき、その質に問題がないと確認されたときに顕微授精によって受精卵の作成を行った。その結果作出された前核期受精卵の細胞質中に黄斑ジストロフィの病因遺伝子(A遺伝子とする)あるいは網膜色素変性の病因遺伝子(B遺伝子とする)を改変するように設計されたCRISPR/CAS9タンパク質あるいはmRNAおよびgRNAを同時に微量注入した。注入された前核期受精卵を体外培養後、正常に分割した質の良いと考えられる受精卵を仮腹となる雌カニクイザルへ胚移植を行った。胚移植後約1ヶ月に超音波画像診断により妊娠を確認した。また、一部の注入胚においては、体外培養の継続後、胚盤胞への発生が確認された。

Strategy for Future Research Activity

昨年度よりCas9のmRNAとタンパク質の両方で個々に胚注入を行ってきたが、タンパク質は凍結できないために、gRNAなどと別途注入が必要であった。マウスとは異なり、カニクイザルでは受精卵を数百単位で準備することは困難であり、今後はCas9 mRNAを中心にgRNAと混合物を適当濃度に調整して、注入受精卵数を増加させたい。妊娠中の胎児おいて遺伝子改変が行われているか否かを確認するために、妊娠中に羊水を採取し、ここからゲノムDNAを抽出し、目的遺伝子が改変されているか否かを確認したものの遺伝子検査をPCR、PCR産物のTAクローニング、およびDNAシークエンスによって実施した。出産時においても胎児由来産物(血液や胎盤など)をサンプルとした遺伝子検査を行い、羊水DNAサンプルとの一致を確認した。残念ながらゲノム編集後に複数個体が生まれているが、目的とする遺伝子改変カニクイザルは作製されていない。作製されれば、哺育および生育状況を見ながら対象個体の眼底観察を実施する。また、成熟卵を採取する方法としてGnRH agonist、FSHおよびhCGを用いたホルモン投与方法に加え、GnRH antagonistを用いた方法あるいはhCG投与から採卵までの時間について卵採取法を行い、受精卵作成の効果や採卵個体への影響について検討する。A遺伝子およびB遺伝子の改変を平行して実施し、CRISPR/CAS9注入胚の胚移植を実施するとともに、胚移植を行わなかった胚において、遺伝子改変の有無を解析する。また一部の胚においては、発生した胚盤胞から内部細胞塊を摘出し、ES細胞の樹立を計る。

Report

(2 results)
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(58 results)

All 2019 2018 2017 Other

All Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Journal Article] Novel biallelic loss-of-function KCNV2 variants in cone dystrophy with supernormal rod responses2019

    • Author(s)
      Kutsuma T, Katagiri S, Hayashi T, Yoshitake K, Iejima D, Gekka T, Kohzaki K, Mizobuchi K, Baba Y, Terauchi R, Matsuura T, Ueno S, Iwata T, Nakano T.
    • Journal Title

      Documenta Ophthalmologica

      Volume: 138(3) Pages: 229-239

    • DOI

      10.1007/s10633-019-09679-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-Resolution Retinal Imaging Reveals Preserved Cone Photoreceptor Density and Choroidal Thickness in Female Carriers of Choroideremia2019

    • Author(s)
      Suzuki K, Gocho K, Akeo K, Kikuchi S, Kubota D, Katagiri S, Fujinami K, Tsunoda K, Iwata T, Yamaki K, Igarashi T, Nakano T, Takahashi H, Hayashi T, Kameya S.
    • Journal Title

      Ophthalmic Surgery, Lasers and Imaging Retina

      Volume: 50(2) Pages: 76-85

    • DOI

      10.3928/23258160-20190129-03

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel mutations in the RS1 gene in Japanese patients with X-linked congenital retinoschisis.2019

    • Author(s)
      Kondo Hiroyuki、Oku Kazuma、Katagiri Satoshi、Hayashi Takaaki、Nakano Tadashi、et al.
    • Journal Title

      Human Genome Varriation

      Volume: 6 Pages: 3-3

    • DOI

      10.1038/s41439-018-0034-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical findings of end-stage retinitis pigmentosa with a homozygous PDE6A variant (p.R653X).2019

    • Author(s)
      Mizobuchi Kei、Katagiri Satoshi、Hayashi Takaaki、Yoshitake Kazutoshi、Fujinami Kaoru、Kuniyoshi Kazuki、Mishima Reimi、Tsunoda Kazushige、Iwata Takeshi、Nakano Tadashi
    • Journal Title

      Am J Ophthalmol Case Rep.

      Volume: 13 Pages: 110-115

    • DOI

      10.1016/j.ajoc.2018.12.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three cases of acute-onset bilateral photophobia.2019

    • Author(s)
      Ueno Shinji、Inooka Daiki、Meinert Monika、Ito Yasuki、Tsunoda Kazushige、Fujinami Kaoru、Iwata Takeshi、Ohde Hisao、Terasaki Hiroko
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 63 Pages: 172-180

    • DOI

      10.1007/s10384-018-00649-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] POSTERIOR STAPHYLOMAS IN EYES WITH RETINITIS PIGMENTOSA WITHOUT HIGH MYOPIA.2019

    • Author(s)
      Xu Xian、Fang Yuxin、Yokoi Tae、Shinohara Kosei、Hirakata Akito、Iwata Takeshi、Tsunoda Kazushige、Jonas Jost B.、Ohno-Matsui Kyoko
    • Journal Title

      Retina.

      Volume: ー Pages: 1-1

    • DOI

      10.1097/iae.0000000000002180

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Compound heterozygous splice site variants in the SCLT1 gene highlight an additional candidate locus for Senior-Loken syndrome.2018

    • Author(s)
      Katagiri S, Hayashi T, Yoshitake K, Murai N, Matsui Z, Kubo H, Satoh H, Matsufuji S, Takamura T, Yokoo T, Omori Y, Furukawa T, Iwata T, Nakano T.
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 16733-16733

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CHANGES OF CONE PHOTORECEPTOR MOSAIC IN AUTOSOMAL RECESSIVE BESTROPHINOPATHY.2018

    • Author(s)
      Nakanishi A, Ueno S, Hayashi T, Katagiri S, Ito Y, Kominami T, Fujinami K, Tsunoda K, Iwata T, Terasaki H.
    • Journal Title

      Retina.

      Volume: 218 Pages: 1782-1787

    • DOI

      10.1097/iae.0000000000002363

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line.2018

    • Author(s)
      Shim MS, Kim KY, Noh M, Ko JY, Ahn S, An MA, Iwata T, Perkins GA, Weinreb RN, Ju WK.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 503(4) Pages: 2690-2697

    • DOI

      10.1016/j.bbrc.2018.08.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KUS121, an ATP regulator, mitigates chorioretinal pathologies in animalmodels of age-related macular degeneration.2018

    • Author(s)
      Muraoka, Y., Yoshimura, N., et al.
    • Journal Title

      Heliyon.

      Volume: 4

    • DOI

      10.1016/j.heliyon.2018.e00624

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of timolol on optineurin aggregation in transformed induced pluripotent stem cells derived from patient with familial glaucoma2018

    • Author(s)
      Inagaki S, Kawase K, Funato M, Seki J, Kawase C, Ohuchi K, Kameyama T, Ando S, Sato A, Morozumi W, Nakamura S, Shimazawa M, Iejima D, Iwata T, Yamamoto T, Kaneko H, Hara H.
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 59(6) Pages: 2293-2304

    • DOI

      10.1167/iovs.17-22975

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LRRTM4-C538Y novel gene mutation is associated with hereditary macular degeneration with novel dysfunction of ON-type bipolar cells.2018

    • Author(s)
      Kawamura Y, Suga A, Fujimaki T, Yoshitake K, Tsunoda K, Murakami A, Iwata T.
    • Journal Title

      J Hum Genet.

      Volume: 63(8) Pages: 893-900

    • DOI

      10.1038/s10038-018-0465-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early onset flecked retinal dystrophy associated with new compound heterozygous RPE65 variants.2018

    • Author(s)
      Katagiri S, Hosono K, Hayashi T, Kurata K, Mizobuchi K, Matsuura T, Yoshitake K, Iwata T, Nakano T, Hotta Y.
    • Journal Title

      Mol Vis.

      Volume: 24 Pages: 286-296

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autosomal dominant retinitis pigmentosa with macular involvement associated with a disease haplotype that included a novel PRPH2 variant (p.Cys250Gly).2018

    • Author(s)
      Katagiri Satoshi、Hayashi Takaaki、Mizobuchi Kei、Yoshitake Kazutoshi、Iwata Takeshi、Nakano Tadashi
    • Journal Title

      Ophthalmic Genet.

      Volume: 39 Pages: 357-365

    • DOI

      10.1080/13816810.2018.1459737

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies seven novel susceptibility loei for primary open-angle glaucoma2018

    • Author(s)
      Shiga Y, Akiyama M, Nishiguchi K M, Sato K, Shimozawa N, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Yamaji T, Iwasaki M, Tsugane S, Oze I, Mikami H, Naito M, Wakai K, Yoshikawa M, Miyake M, Yanaka T, et al.
    • Journal Title

      Human Molecular Genetics

      Volume: 27 Issue: 8 Pages: 1486-1496

    • DOI

      10.1093/hmg/ddy053

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of genotyping method for functionally relavant variants of cytochromes P450 in cynomogus macaques.2018

    • Author(s)
      Uno Y, Osada N, Sakurai S, Shimozawa N, Iwata T, Ikeo K, Yamazaki H.
    • Journal Title

      Journal of Veterinary Pharmacology and Therapeutics

      Volume: 41

    • DOI

      10.1111/jvp.12443

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early Patterns of Macular Degeneration in ABCA4 -Associated Retinopathy2018

    • Author(s)
      Khan KN, Kasilian M, Mahroo OAR, Tanna P, Kalitzeos A, Robson AG, Tsunoda K, Iwata T, Moore AT, Fujinami K, Michaelides M.
    • Journal Title

      Ophthalmology

      Volume: 125(5) Pages: 735-746

    • DOI

      10.1016/j.ophtha.2017.11.020

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Case of cone dystrophy with normal fundus appearance associated with biallelic POC1B variants.2018

    • Author(s)
      Kominami Azusa、Ueno Shinji、Kominami Taro、Nakanishi Ayami、Ito Yasuki、Fujinami Kaoru、Tsunoda Kazushige、Hayashi Takaaki、Kikuchi Sachiko、Kameya Shuhei、Iwata Takeshi、Terasaki Hiroko
    • Journal Title

      Ophthalmic Genet

      Volume: 39 Pages: 255-262

    • DOI

      10.1080/13816810.2017.1408846

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Missense variants in the X-linked gene PRPS1 cause retinal degeneration in females.2018

    • Author(s)
      Fiorentino Alessia、Fujinami Kaoru、(Hayashi Takaaki)、Iwata Takeshi、Parker Matthew、Webster Andrew R.、Michaelides Michel、Hardcastle Alison J.、for the 100,000 Genomes Project, the Japan Eye Genetic Consortium and the UK Inherited Retinal Dystrophy Consortium
    • Journal Title

      Hum Mutat.

      Volume: 39 Pages: 80-91

    • DOI

      10.1002/humu.23349

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7.2017

    • Author(s)
      Shiga Yukihiro、Kashiwagi Kenji、Nakazawa Toru、for the Japan Glaucoma Society Omics Group (JGS-OG)
    • Journal Title

      PLoS One.

      Volume: 12

    • DOI

      10.1371/journal.pone.0186678

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Parafoveal photoreceptor abnormalities in asymptomatic patients with RP1L1 mutations in families with occult macular dystrophy2017

    • Author(s)
      Kato Y, Hanazono G, Fujinami K, Hatase T, Kawamura Y, Iwata T, Miyake Y, Tsunoda K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 58(14) Pages: 6020-6029

    • DOI

      10.1167/iovs.17-21969

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy.2017

    • Author(s)
      Shinozaki Y, Kashiwagi K, Namekata K, Takeda A, Ohno N, Robaye B, Harada T, Iwata T, *Koizumi S
    • Journal Title

      JCI Insight.

      Volume: 2

    • DOI

      10.1172/jci.insight.93456

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic variant near PLXDC2 Influences the risk of primary open-angle glaucoma by increasing intraocular pressure in the Japanese population2017

    • Author(s)
      Mabuchi F, Mabuchi N, Takamoto M, Sakurada Y, Yoneyama S, Kashiwagi K, Iijima H, Yamagata Z, Aihara M, Iwata T, Araie M. Japan Glaucoma Society Omics Group (JGS-OG).
    • Journal Title

      Journal of Glaucoma

      Volume: 26(11) Pages: 963-966

    • DOI

      10.1097/ijg.0000000000000790

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration2017

    • Author(s)
      Yamashiro K, Mori K, Honda S, Kano M, Yanagi Y, Obana A, Sakurada Y, Sato T, Nagai Y, Hikichi T, Kataoka Y, Hara C, Koyama Y, Koizumi H, Yoshikawa M, Miyake M, Nakata I, Tsuchihashi T, Horie-Inoue K, et al.
    • Journal Title

      Scientific Reports

      Volume: 7(1) Pages: 9196-9196

    • DOI

      10.1038/s41598-017-09632-0

    • NAID

      120006373777

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Additive effects of genetic variants associated with intraocular pressure in primary open-angle glaucoma2017

    • Author(s)
      Mabuchi F, Mabuchi N, Sakurada Y, Yoneyama S, Kashiwagi K, Iijima H, Yamagata Z, Takamoto M, Aihara M, Iwata T, Kawase K, Shiga Y, Nishiguchi KM, Nakazawa T, Ozaki M, Araie M; Japan Glaucoma Society Omics Group (JGS-OG).
    • Journal Title

      PLOS ONE

      Volume: 12(8)

    • DOI

      10.1371/journal.pone.0183709

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterozygous deletion of the OPA1 gene in patients with dominant optic atrophy2017

    • Author(s)
      Hayashi T, Sasano H, Katagiri S, Tsunoda K, Kameya S, Nakazawa M, Iwata T, Tsuneoka H.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 61 Pages: 395-401

    • DOI

      10.1007/s10384-017-0522-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Update on the Global Eye Genetics Consortium2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      XIVth Biennial SAARC Academy of Opththalmology (SAO) Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Establishment of Asian Eye Genetics Consortium (AEGC, http://asiangenetics.) by 20 countries2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      XIVth Biennial SAARC Academy of Opththalmology (SAO) Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Identifying novel genes for hereditary retinal diseases and development of drug for glaucoma from the Japan Eye Genetics Consortium2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      XIVth Biennial SAARC Academy of Opththalmology (SAO) Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Asia and the Global Eye Genetics Consortium: A research based consortium for advances in vision research2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      he Founding Conference of the Global Eye Genetics Consortium (GEGC)Chinese Branch & The First Academic Confernce on Eye Genetics Disease
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] [KEY NOTE TALK]Neuroprotection of Optineurin E50K Knok-in Mice with Normal Tension Glaucoma by TBK1 Inhibitor Amlexanox2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      ARVO India 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal Models for Eye Diseases2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      ARVO India
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Age-related Macular Degeneration2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      ARVO India
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanisms of transcriptional regulation by ARMS2/HTRA1 haplotype as risk factor for age-rerated macular degeneration2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      International Symposium on Retinal Degeneration 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular characteristic of macular suscepribility for dysfunction and degeneration2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      International Society for Eye Research 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ARMS2/HTRA1 as Potential Theraperutic Target for Age-related Macular Degeneration2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      International Society for Eye Research 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 緑内障遺伝子解析から個別医療へ2018

    • Author(s)
      岩田岳
    • Organizer
      第29回日本緑内障学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Global Eye Genetics Consortium (GEGC)2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      All India Ophthalmological Society Conference 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Global Eye Genetics Consortium (GEGC)2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      Asia-Pacific Academy of Ophthalmology Congress 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 座長:基礎研究から病態を捉える2018

    • Author(s)
      岩田岳
    • Organizer
      Retinal Research Forum 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Asian Eye Genetics Consortium.2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      APAO 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Establishment of the Asian Eye Genetics Consortium to Study Eye Diseases Associated with Gene Sequence. Introduction of Network and Finding of Novel Genes Responsible for LCA, Optic Neuropathy, and Others.2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      APAO 2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] HTRA1 as Potential Therapeutic Target for Age-Related Macular Degeneration.2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      APAO 2018
    • Related Report
      2017 Annual Research Report
  • [Presentation] Establishment and Activity of the Asian Eye Genetics Consortium (AEGC).<Poster Session>2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      HGM 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimized Homology Directed Repair for Treatment of Inherited Retinal Diseases Using the CRISPR/Cas9 System.<Poster Session>2018

    • Author(s)
      Takeshi Iwata
    • Organizer
      HGM 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Asian Eye Genetics Consortium: International collaboration to accelerate identification of novel disease-causing genes.2017

    • Author(s)
      Takeshi Iwata
    • Organizer
      ARVO-Asia 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] International Collaborations to Identify Novel Genes Responsible for Hereditary Retinal Diseases in the Asia Population.2017

    • Author(s)
      Takeshi Iwata
    • Organizer
      APAO Conress2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新規緑内障遺伝子や発症機序からの薬剤開発2017

    • Author(s)
      岩田 岳
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 遺伝性網脈絡膜疾患の網羅的解析:オールジャパンからアジアへの展開2017

    • Author(s)
      岩田 岳
    • Organizer
      バイエル レチナアワード、第121回日本眼科学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Coordinated Strategy for Genetic Eye Research in Asia and the Pasific.2017

    • Author(s)
      Takeshi Iwata
    • Organizer
      ARVO 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] International network in eye disease-the Asian Eye Genetics Consortium (AEGC). <Poster Session>2017

    • Author(s)
      Takeshi Iwata
    • Organizer
      ARVO 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 全エクソーム解析による遺伝性網膜疾患の病因・病態機序の解明2017

    • Author(s)
      岩田 岳
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Annual Research Report
  • [Book] Advances in Vision Research Volume II, Essentials in Ophthalmology2018

    • Author(s)
      Gyan Prakash and Takeshi Iwata (Eds)
    • Total Pages
      468
    • Publisher
      Springer Nature
    • ISBN
      9789811308833
    • Related Report
      2018 Annual Research Report
  • [Book] 遺伝子医学 MOOK2018

    • Author(s)
      須賀晶子、吉武和敏、岩田岳(編集:松本直道、難波栄二、古川洋一)
    • Total Pages
      216
    • Publisher
      オミックス解析による遺伝性網脈絡膜疾患の病因・病態機序の解明、臨床応用に向けた疾患シークエンス解析
    • ISBN
      9784944157280
    • Related Report
      2018 Annual Research Report
  • [Book] Advances in Vision Research, Volume I2017

    • Author(s)
      Prakash, Gyan, Iwata, Takeshi (Eds.)
    • Total Pages
      523
    • Publisher
      Springer
    • ISBN
      9784431565116
    • Related Report
      2017 Annual Research Report
  • [Remarks] 独立行政法人国立病院機構東京医療センター 感覚器センター 分子細胞生物学研究部

    • URL

      http://www.kankakuki.go.jp/lab_e.html

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] Iwata Laboratory

    • URL

      http://www.iwatalab.org/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 加齢黄斑変性の診断マーカー、診断キット、診断補助方法、及び、発症リスク判定方法2018

    • Inventor(s)
      岩田岳、野田徹、家島大輔
    • Industrial Property Rights Holder
      岩田岳、野田徹、家島大輔
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-07-21   Modified: 2019-12-27  

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