Research Project
Grant-in-Aid for Research Activity Start-up
Plaque samples were obtained from the site of peri-implantitis and periodontitis in the same oral cavity. Genomic information of the bacteria from the sites was comprehensively analyzed. These analysis results were compared and we clarified the causes of difference between the two diseases.DNA was extracted from the samples. Metagenomic analysis was performed to analyze whole genome information and meta 16S rDNA analysis was performed to specify the bacterial species. The results were integrated and the network analysis was performed.The profiles of bacterial species were similar in the two diseases.However, the core network structures, the bacterial species that form the core network structure, and the functional composition of the microbiome were different in both diseases.
インプラント周囲炎は歯周炎と類似した臨床症状を呈するが、インプラント周囲炎は歯周炎に比べ罹患率が高い。加えて、歯周炎では有効な治療効果が得られた方法を駆使しても必ずしも良好な結果が得られないことが報告されている。歯周炎は様々な全身疾患との関連が考えられており、インプラント周囲炎に関与する細菌もまた全身の健康に影響を与えると推測される。本研究により疾患特異的な代謝状態、具体的な病原細菌叢のもつ機能を評価し、治療の標的となる細菌種、機能遺伝子を特定し新規予防・治療法の開発を行う。インプラント周囲炎原因の究明と新規治療法開発は喫緊の課題であり、本研究は国民の今後のQOL向上に寄与すると考えられる。
All 2019 2018 2017 Other
All Journal Article (6 results) (of which Int'l Joint Research: 4 results, Peer Reviewed: 6 results, Open Access: 5 results) Presentation (10 results) (of which Int'l Joint Research: 4 results, Invited: 2 results) Book (3 results) Remarks (1 results)
Clinical Oral Investigations
Volume: 23 Issue: 3 Pages: 1489-1493
10.1007/s00784-019-02805-3
Progress in Orthodontics
Volume: 20 Issue: 1 Pages: 11-11
10.1186/s40510-019-0265-1
Oral Diseases
Volume: 25(3) Issue: 3 Pages: 868-880
10.1111/odi.13044
Frontiers in Microbiology
Volume: 9 Pages: 2470-2470
10.3389/fmicb.2018.02470
Acta Odontologica Scandinavica
Volume: 15 Issue: 6 Pages: 1-9
10.1080/00016357.2018.1426876
Scientific Reports
Volume: 7 Issue: 1 Pages: 13950-13950
10.1038/s41598-017-14260-9
http://reins.tmd.ac.jp/html/100011966_ja.html
