| Project/Area Number |
17H06691
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
Setsu Toru
Kamimura Kenya
Takamura Masaaki
Terai Shuji
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| Project Period (FY) |
2017-08-25 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 組織線維化 / 肝筋相関 / 肝腎相関 / サルコペニア / 肝線維化 / 肝星細胞 / 肝内リンパ濾胞 / 肝リンパ濾胞組織 / 活性化肝星細胞 / 老化星細胞 |
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| Outline of Final Research Achievements |
Reactive lymphoid follicle in the liver has been detected in the patients chronic hepatitis C(CH-C),primary biliary cholingitis and autoimmune hepatitis.
The hepatic mass lesion characterized by a dense circumscribed, expansively growing lymphocyte infiltrate with lymph follicles and sometimes germinal centers. Using immunohistological methods, we studied the lymphoid follicles in liver biopsy specimens obtained from the CH-C patients before interferon and DAA therapy. We analyzed various immunocompetent cells in the surrounding interface area that appeared to be differentiated in tissues with lymphoid follicles. Mainly we detected an interesting finding about the relationship with hepatic stellate cells.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで多額の国費を含めた投じられたC型肝炎の研究・治療について、医療において貢献をうける方は多かったが、これを後方視的に解析を行い、採取された既存の検体や組織を有効利用して、線維化改善のための研究結果を得た。高額の機器を利用することなく貴重な科研費を利用して肝-筋-腎の多臓器相関の結果を得た。老化現象がGDP伸び率1.27倍に対して、医療費1.54倍、介護費2.34倍という超高齢社会問題を引き起こす諸問題の観点から今後組織線維化対策につながる。
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